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Pharmaceutical Extrusion Technology

Author: Isaac Ghebre-Selassie
Publisher: CRC Press
ISBN: 0824755200
Size: 80.85 MB
Format: PDF, Kindle
View: 561
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Pharmaceutical Extrusion Technology is the only resource to provide in-depth descriptions and analyses of the key parameters of extruders and extrusion processes. The book highlights the applicability of melt extrusion in pharmaceutical drug development and product manufacturing, including controlled release, dissolution rate and bioavailability enhancement, and granulation technology. It brings together the technical information necessary to develop and market pharmaceutical dosage forms that meet current quality and regulatory requirements and details extruder hardware and controls, process definition and troubleshooting of single and twin screw extrusion processes, and more.

Pharmaceutical Extrusion Technology Second Edition

Author: Isaac Ghebre-Sellassie
Publisher: CRC Press
ISBN: 1351129007
Size: 14.81 MB
Format: PDF
View: 1435
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The first edition of Pharmaceutical Extrusion Technology, published in 2003, was deemed the seminal book on pharmaceutical extrusion. Now it is expanded and improved, just like the usage of extrusion has expanded, improved and evolved into an accepted manufacturing technology to continuously mix active pharmaceutical ingredients with excipients for a myriad of traditional and novel dosage forms. Pharmaceutical Extrusion Technology, Second Edition reflects how this has spawned numerous research activities, in addition to hardware and process advancements. It offers new authors, expanded chapters and contains all the extrusion related technical information necessary for the development, manufacturing, and marketing of pharmaceutical dosage forms.

Pharmaceutical Extrusion Technology Second Edition

Author: Isaac Ghebre-Sellassie
Publisher: Drugs and the Pharmaceutical Sciences
ISBN: 9781498704915
Size: 50.59 MB
Format: PDF, Kindle
View: 2168
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The first edition of Pharmaceutical Extrusion Technology , published in 2003, was deemed the seminal book on pharmaceutical extrusion. Now it is expanded and improved, just like the usage of extrusion has expanded, improved and evolved into an accepted manufacturing technology to continuously mix active pharmaceutical ingredients with excipients for a myriad of traditional and novel dosage forms. Pharmaceutical Extrusion Technology, Second Edition reflects how this has spawned numerous research activities, in addition to hardware and process advancements. It offers new authors, expanded chapters and contains all the extrusion related technical information necessary for the development, manufacturing, and marketing of pharmaceutical dosage forms.

Melt Extrusion

Author: Michael A. Repka
Publisher: Springer Science & Business Media
ISBN: 1461484324
Size: 32.73 MB
Format: PDF, ePub
View: 2743
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This volume provides readers with the basic principles and fundamentals of extrusion technology and a detailed description of the practical applications of a variety of extrusion processes, including various pharma grade extruders. In addition, the downstream production of films, pellets and tablets, for example, for oral and other delivery routes, are presented and discussed utilizing melt extrusion. This book is the first of its kind that discusses extensively the well-developed science of extrusion technology as applied to pharmaceutical drug product development and manufacturing. By covering a wide range of relevant topics, the text brings together all technical information necessary to develop and market pharmaceutical dosage forms that meet current quality and regulatory requirements. As extrusion technology continues to be refined further, usage of extruder systems and the array of applications will continue to expand, but the core technologies will remain the same.

Hydrophilic Matrix Tablets For Oral Controlled Release

Author: Peter Timmins
Publisher: Springer
ISBN: 1493915193
Size: 68.19 MB
Format: PDF, Docs
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This detailed volume addresses key issues and subtle nuances involved in developing hydrophilic matrix tablets as an approach to oral controlled release. It brings together information from more than five decades of research and development on hydrophilic matrix tablets and provides perspective on contemporary issues. Twelve comprehensive chapters explore a variety of topics including polymers (hypromellose, natural polysaccharides and polyethylene oxide) and their utilization in hydrophilic matrices, critical interactions impacting tablet performance, in vitro physical and imaging techniques, and microenvironmental pH control and mixed polymer approaches, among others. In one collective volume, Hydrophilic Matrix Tablets for Oral Controlled Release provides a single source of current knowledge, including sections of previously unpublished data. It is an important resource for industrial and academic scientists investigating and developing these oral controlled release formulations.

Hot Melt Extrusion

Author: Dennis Douroumis
Publisher: John Wiley & Sons
ISBN: 0470711183
Size: 43.23 MB
Format: PDF
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"First book related to the use of hot melt extrusion for pharmaceutical applications"--

Aulton S Pharmaceutics

Author: Michael E. Aulton
Publisher: Elsevier Health Sciences
ISBN: 0702042900
Size: 60.89 MB
Format: PDF, ePub
View: 709
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Pharmaceutics is one of the most diverse subject areas in all of pharmaceutical science. In brief, it is concerned with the scientific and technological aspects of the design and manufacture of dosage forms or medicines. An understanding of pharmaceutics is therefore vital for all pharmacists and those pharmaceutical scientists who are involved with converting a drug or a potential drug into a medicine that can be delivered safely, effectively and conveniently to the patient. Now in its fourth edition, this best-selling textbook in pharmaceutics has been brought completely up to date to reflect the rapid advances in delivery methodologies by eye and injection, advances in drug formulations and delivery methods for special groups (such as children and the elderly), nanomedicine, and pharmacognosy. At the same time the editors have striven to maintain the accessibility of the text for students of pharmacy, preserving the balance between being a suitably pitched introductory text and a clear reflection of the state of the art. provides a logical, comprehensive account of drug design and manufacture includes the science of formulation and drug delivery designed and written for newcomers to the design of dosage forms New to this edition New editor: Kevin Taylor, Professor of Clinical Pharmaceutics, School of Pharmacy, University of London. Twenty-two new contributors. Six new chapters covering parenteral and ocular delivery; design and administration of medicines for the children and elderly; the latest in plant medicines; nanotechnology and nanomedicines, and the delivery of biopharmaceuticals. Thoroughly revised and updated throughout.

Aulton S Pharmaceutics E Book

Author: Michael E. Aulton
Publisher: Elsevier Health Sciences
ISBN: 0702053937
Size: 20.95 MB
Format: PDF, ePub, Mobi
View: 7591
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Pharmaceutics is one of the most diverse subject areas in all of pharmaceutical science. In brief, it is concerned with the scientific and technological aspects of the design and manufacture of dosage forms or medicines. An understanding of pharmaceutics is therefore vital for all pharmacists and those pharmaceutical scientists who are involved with converting a drug or a potential drug into a medicine that can be delivered safely, effectively and conveniently to the patient. Now in its fourth edition, this best-selling textbook in pharmaceutics has been brought completely up to date to reflect the rapid advances in delivery methodologies by eye and injection, advances in drug formulations and delivery methods for special groups (such as children and the elderly), nanomedicine, and pharmacognosy. At the same time the editors have striven to maintain the accessibility of the text for students of pharmacy, preserving the balance between being a suitably pitched introductory text and a clear reflection of the state of the art. New to this edition New editor: Kevin Taylor, Professor of Clinical Pharmaceutics, School of Pharmacy, University of London. Twenty-two new contributors. Six new chapters covering parenteral and ocular delivery; design and administration of medicines for the children and elderly; the latest in plant medicines; nanotechnology and nanomedicines, and the delivery of biopharmaceuticals. Thoroughly revised and updated throughout. provides a logical, comprehensive account of drug design and manufacture includes the science of formulation and drug delivery designed and written for newcomers to the design of dosage forms New to this edition New editor: Kevin Taylor, Professor of Clinical Pharmaceutics, School of Pharmacy, University of London. Twenty-two new contributors. Six new chapters covering parenteral and ocular delivery; design and administration of medicines for the children and elderly; the latest in plant medicines; nanotechnology and nanomedicines, and the delivery of biopharmaceuticals. Thoroughly revised and updated throughout.

Handbook Of Pharmaceutical Granulation Technology Third Edition

Author: Dilip M. Parikh
Publisher: CRC Press
ISBN: 1616310030
Size: 11.40 MB
Format: PDF, ePub, Mobi
View: 4124
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The Third Edition presents all pharmaceutical industry personnel and those in academia with critical updates on the recent advances in granulation technology and changes in FDA regulatory guidelines. Addressing precisely how these recent innovations and revisions affect unit operation of particle generation and granulation, this text assists the reader in selecting the ideal technology for his/her company’s particular drug delivery system. This knowledge helps ensure that regulatory guidelines are followed and met in a cost-effective manner. Here are just a few of the new topics discussed in this revised and expanded handbook: spray drying nanotechnology biotechnologically derived drugs nutraceuticals controlled release drugs particle engineering supercritical fluids concepts of design space process optimization regulation harmonization by global health authorities process controlexpert systems Process Analytical Technology (PAT) regulatory issues in granulation In addition, all chapters in the Handbook of Pharmaceutical Granulation Technology explore the fundamentals of powder characterization, granulation, and state-of-the-art technologies, modeling, application of expert systems, and manufacturing optimization.

Der Gleichl Ufige Doppelschneckenextruder

Author: Klemens Kohlgrüber
Publisher: Carl Hanser Verlag GmbH Co KG
ISBN: 3446452354
Size: 17.75 MB
Format: PDF, ePub, Mobi
View: 179
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Alles zum gleichläufigen Doppelschneckenextruder Bei der Herstellung von Kunststoffen, insbesondere bei der Aufbereitung und Verarbeitung bis zum Fertigprodukt werden Extruder eingesetzt, wobei der gleichläufige Doppelschneckenextruder eine dominante Rolle spielt. Aber auch in anderen Industriezweigen, z. B. der Kautschuk- und Lebensmittelindustrie und zunehmend in der Pharmaindustrie kommen die Gleichdrallschnecken vielfältig zum Einsatz. Eine multifunktionale Maschine Das Fachbuch gibt umfassenden Einblick in die verfahrens- und maschinentechnischen Grundlagen und legt großen Fokus auf Praxisbeispiele. Meist sind die Schnecken modular aufgebaut und können damit sehr flexibel an veränderte Aufgabenstellung und Produkteigenschaften angepasst werden. Für die optimale Auslegung eines Doppelschneckenextruders sind vertiefte Kenntnisse über die Maschine und den Prozess erforderlich. Ein Praxisbuch für Einsteiger und Profis Die zweite Auflage entstand unter Mitwirkung vieler Fachautoren von renommierten Firmen und Hochschulen. Alle inzwischen erfolgten Weiterentwicklungen wurden berücksichtigt. Die zweite Auflage wurde durchgehend neu bearbeitet, ist deutlich erweitert, komplett in Farbe und in neuem Layout. Mit Zusatzmaterial auf der Website des Herausgebers: Videos, Bilder, Beispiel-Aufgaben, Rechentools EXTRA: E-Book inside