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Post Transcriptional Gene Regulation

Author: Jane Wu
Publisher: John Wiley & Sons
ISBN: 3527665412
Size: 18.65 MB
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Reflecting the rapid progress in the field, the book presents the current understanding of molecular mechanisms of post-transcriptional gene regulation thereby focusing on RNA processing mechanisms in eucaryotic cells. With chapters on mechanisms as RNA splicing, RNA interference, MicroRNAs, RNA editing and others, the book also discusses the critical role of RNA processing for the pathogenesis of a wide range of human diseases. The interdisciplinary importance of the topic makes the title a useful resource for a wide reader group in science, clinics as well as pharmaceutical industry.

Rna Processing

Author: Steve J. Higgins
Publisher: Oxford University Press
ISBN: 9780199634705
Size: 31.32 MB
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As post-transcriptional events become increasingly recognized as critical regulation sites of gene expression in eukaryotic cells, research interest in RNA processing has grown more and more intense. RNA Processing: A Practical Approach, available in two volumes, offers detailed guidance on all major aspects of the subject. Step-by-step protocols from leading laboratories are presented for studying the termination, end-processing, capping, methylation, splicing, and editing of mRNA. Protocols designed for the study of mRNA stability and processing of rRNA and tRNA are included as well, with full descriptions of the synthesis and purification of RNA substrate for in vitro work, the characterization of specific RNAs, and the isolation and analysis of ribonucleoprotein complexes. Taken together, the two volumes are invaluable laboratory companions to researchers working in mRNA, rRNA, and tRNA expression. The contributors' lucid explanatory style and comprehensive coverage will be welcomed by both experienced researchers and students embarking on such studies for the first time.

Pre Mrna Processing

Author: Angus I. Lamond
Publisher: Springer Science & Business Media
ISBN: 3662223252
Size: 46.48 MB
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he past fifteen years have seen tremendous growth in our understanding of T the many post-transcriptional processing steps involved in producing func tional eukaryotic mRNA from primary gene transcripts (pre-mRNA). New processing reactions, such as splicing and RNA editing, have been discovered and detailed biochemical and genetic studies continue to yield important new insights into the reaction mechanisms and molecular interactions involved. It is now apparent that regulation of RNA processing plays a significant role in the control of gene expression and development. An increased understanding of RNA processing mechanisms has also proved to be of considerable clinical importance in the pathology of inherited disease and viral infection. This volume seeks to review the rapid progress being made in the study of how mRNA precursors are processed into mRNA and to convey the broad scope of the RNA field and its relevance to other areas of cell biology and medicine. Since one of the major themes of RNA processing is the recognition of specific RNA sequences and structures by protein factors, we begin with reviews of RNA-protein interactions. In chapter 1 David Lilley presents an overview of RNA structure and illustrates how the structural features of RNA molecules are exploited for specific recognition by protein, while in chapter 2 Maurice Swanson discusses the structure and function of the large family of hnRNP proteins that bind to pre-mRNA. The next four chapters focus on pre-mRNA splicing.

Biochemistry

Author: Victor L. Davidson
Publisher: Lippincott Williams & Wilkins
ISBN: 9780683305036
Size: 57.26 MB
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NMS Biochemistry, Fourth Edition, is designed to help medical students successfully complete a course in biochemistry and prepare for USMLE Step 1. This new edition has been significantly updated, and extensively rewritten to emphasize medical relevance.

Molecular Biology

Author: Alexander McLennan
Publisher: Garland Science
ISBN: 0415684161
Size: 72.77 MB
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Rev. ed. of: Molecular biology / Phil Turner ... [et al.]. 3rd ed. New York, NY: Taylor & Francis, 2005.

Gene Regulation

Author: David Latchman
Publisher: Garland Science
ISBN: 0203016335
Size: 29.81 MB
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Gene regulation is an essential process in the development and maintenance of a healthy body, and as such, is a central focus in both basic science and medical research. Gene Regulation, Fifth Edition provides the student and researcher with a clear, up-to-date description of gene regulation in eukaryotes, distilling the vast and complex primary literature into a concise overview.

Gene Regulation

Author: David S. Latchman
Publisher: Garland Science
ISBN: 9780748765300
Size: 41.82 MB
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This lucid, well structured and jargon-free book provides an up-to-date and comprehensive account of the processes involved in gene expression and the mechanisms by which such expression is regulated. New information on how viruses modify host gene regulation has been included in this new edition. Methods used to analyze gene expression have also been given more attention, with a new section added on methods for examining DNA binding by transcriptional factors.

Post Transcriptional Control Of Gene Expression In Plants

Author: Witold Filipowicz
Publisher: Springer Science & Business Media
ISBN: 9400903537
Size: 41.44 MB
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A recent volume of this series (Signals and Signal Transduction Pathways in Plants (K. Palme, ed.) Plant Molecular Biology 26, 1237-1679) described the relay races by which signals are transported in plants from the sites of stimuli to the gene expression machinery of the cell. Part of this machinery, the transcription apparatus, has been well studied in the last two decades, and many important mechanisms controlling gene expression at the transcriptional level have been elucidated. However, control of gene expression is by no means complete once the RNA has been produced. Important regulatory devices determine the maturation and usage of mRNA and the fate of its translation product. Post-transcriptional regulation is especially important for generating a fast response to environmental and intracellular signals. This book summarizes recent progress in the area of post-transcriptional regulation of gene expression in plants. 18 chapters of the book address problems of RNA processing and stability, regulation of translation, protein folding and degradation, as well as intracellular and cell-to-cell transport of proteins and nucleic acids. Several chapters are devoted to the processes taking place in plant organelles.

Grundlagen Der Molekularen Medizin

Author: Detlev Ganten
Publisher: Springer-Verlag
ISBN: 3662075881
Size: 16.70 MB
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Die Zunahme unserer Kenntnisse über die molekularen Mechanismen u.a. von Wachstums-, Entwicklungs- und Differenzierungsprozessen hat die Grundlagen der molekularen Medizin innerhalb weniger Jahre erheblich erweitert. In besonderer Weise hat die Aufklärung der Basensequenz des menschlichen Genoms zu dieser Entwicklung beigetragen und die Bildung neuer Forschungsfelder wie Genomics und Proteomics ausgelöst. Die vorliegende Neuauflage der molekular- und zellbiologischen Grundlagen der Molekularen Medizin will diesen Fortschritt begleiten. In 24 Kapiteln wird der aktuelle Kenntnisstand der Molekularen Medizin von ausgewiesenen Experten dargestellt. Dieser Band sei all denen empfohlen, die als Biowissenschaftler - seien es Mediziner, Biologen, Biochemiker oder Biophysiker - an diesem Fortschritt teilhaben wollen.