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Radiation Proteomics

Author: Dariusz Leszczynski
Publisher: Springer Science & Business Media
ISBN: 9400758960
Size: 75.52 MB
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Methods of proteomics have been shown to be powerful tools in search of target proteins – proteins that respond in cells to an internal or an external stimulus. Proteomics is widely used in biomedical research. However, in radiation biology research, following exposures of living matter to low doses of either ionizing or non-ionizing radiation, proteomics approach is only very slowly gaining support. This book, by presenting the current status of the use of proteomics in radiation biology, will help to attract attention to the field of radiation proteomics.

Oxygen Transport To Tissue Xxxiv

Author: William J. Welch
Publisher: Springer Science & Business Media
ISBN: 1461449898
Size: 18.26 MB
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From the 39th annual conference of the International Society on Oxygen Transport to Tissue (ISOTT), held in Washington, DC, USA in July 2011, this volume covers aspects of oxygen transport from air to the cells, organs and organisms; instrumentation and methods to sense oxygen and clinical evidence. Oxygen Transport to Tissue XXXIV includes contributions from scientists (physicists, biologists and chemists), engineers, clinicians and mathematicians.

Find Me I M Yours

Author: Hillary Carlip
Publisher: RosettaBooks
ISBN: 0795343272
Size: 45.17 MB
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"If you believe in destiny like I do, and you think there's even a remote possibility we're meant to be together, then find me I'm yours." —Mr. WTF In one sentence—one serendipitous moment—everything Mags Marclay, an offbeat, wry, 24-year-old struggling artist living in L.A., has ever known is forever changed as she is led on a treasure hunt to find her soul mate. Find Me I’m Yours is a highly entertaining, unconventional virtual page-turner. Become immersed in Mags’s world through original artwork, hand-written lists, graphics, and Instagram photos within the book. You can go even deeper into the Find Me I’m Yours universe by clicking on embedded links leading to interactive content that’s expertly woven through the novel, including: • Original rom-com style VIDEOS that star the handsome stranger Mags dubs “Mr. WTF,” who gives clues to the hunt. • Thirty-three unique, custom-designed WEBSITES that further the narrative, blur the lines between fiction and reality, and offer endless ways for you to enjoy additional original content, including reality and comedy series featuring A-list talent. • OPPORTUNITIES for you to share your own content (artwork, stories, songs, apologies, wishes, etc.), interact, connect, and personally engage with the story. This revolutionary CLICK LIT® novel was conceived from the get-go as an ever-expanding, multi-platform entertainment experience. Created, written, and designed by award-winning author, artist, and digital innovator Hillary Carlip, and co-created, directed, and produced by Golden Globe-winning and Emmy-nominated TV comedy writer/producer/director Maxine Lapiduss, Find Me I’m Yours is a game changer in the way that stories are told and experienced.

Renal And Urinary Proteomics

Author: Visith Thongboonkerd
Publisher: John Wiley & Sons
ISBN: 3527319743
Size: 64.12 MB
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Based on research and results from the international Human Kidney and Urine Proteome Project, this handbook and reference presents current methods and protocols for the analysis of human kidney and urine. The world's leading experts cover everything from basic techniques for routine analysis to advanced methods for difficult samples or analytes. Written with the practitioner in mind, all the methods and techniques are described with step-by-step protocols backed by much valuable practical advice taken from real life experiments.

Rare Diseases Epidemiology

Author: Manuel Posada de la Paz
Publisher: Springer
ISBN: 9789400733381
Size: 45.98 MB
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In our etiologic research, we epidemiologists need to leave behind the concepts of ‘cohort’ study and ‘case–control’ study and adopt that of the etiologic study as the singular substitute for these. With this sentence, the famous epidemiologist Professor Olli S. Miettinen began his personal re ection on the future of the epidemiology [1]. He sought to highlight the fact that the role of the epidemiologist should be mainly focused on aetiological research. Nevertheless, the widespread idea still exists that epidemiology is limited to purely providing gures and descriptive data on the frequency and distribution of disease. Indeed, it is more than likely that the precise aim of those rst classic epidemiological steps, i. e. , methods essentially based on describing the distri- tion of a given disease, is still not all that well understood by many scientists, let alone the general public. Such descriptions seek to generate hypotheses and afford explanations for key factors (be these risk factors or the presumable causes th- selves), which might justify differences in terms of persons, time or place and, in turn, ultimately serve to develop preventive measures and/or gain quality-adjusted life years. To restrict the goals of epidemiology to activities exclusively concerned with reporting gures or even complex statistical results is a great mistake, one that renders it dif cult to take full advantage of the epidemiologist’s true role, which is “to study disease determinants and to assess the actual impact of factors involved in their development, distribution and dissemination”.

Peroxisomes And Their Key Role In Cellular Signaling And Metabolism

Author: Luis A. del Rio
Publisher: Springer Science & Business Media
ISBN: 9400768893
Size: 51.27 MB
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Peroxisomes are a class of ubiquitous and dynamic single membrane-bounded cell organelles, devoid of DNA, with an essentially oxidative type of metabolism. In recent years it has become increasingly clear that peroxisomes are involved in a range of important cellular functions in almost all eukaryotic cells. In higher eukaryotes, including humans, peroxisomes catalyze ether phospholipids biosynthesis, fatty acid alpha-oxidation, glyoxylate detoxification, etc, and in humans peroxisomes are associated with several important genetic diseases. In plants, peroxisomes carry out the fatty acid beta-oxidation, photorespiration, metabolism of ROS, RNS and RSS, photomorphogenesis, biosynthesis of phytohormones, senescence, and defence against pathogens and herbivores. In recent years it has been postulated a possible contribution of peroxisomes to cellular signaling. In this volume an updated view of the capacity and function of peroxisomes from human, animal, fungal and plant origin as cell generators of different signal molecules involved in distinct processes of high physiological importance is presented.

Transcriptional And Translational Regulation Of Stem Cells

Author: Gary Hime
Publisher: Springer Science & Business Media
ISBN: 9400766211
Size: 16.95 MB
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This volume describes the latest findings on transcriptional and translational regulation of stem cells. Both transcriptional activators and repressors have been shown to be crucial for the maintenance of the stem cell state. A key element of stem cell maintenance is repression of differentiation factors or developmental genes – achieved transcriptionally, epigenetically by the Polycomb complex, and post-transcriptionally by RNA-binding proteins and microRNAs. This volume takes two approaches to this topic – (1) illustrating the general principles outlined above through a series of different stem cell examples – embryonic, iPS and adult stem cells, and (2) describing several molecular families that have been shown to have roles in regulation of multiple stem cell populations.

Proteomic Profiling

Author: Anton Posch
Publisher: Humana Press
ISBN: 9781493925490
Size: 20.40 MB
Format: PDF
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This volume presents the latest developments of the main pillars of protein analysis, such as sample preparation, separation and characterization. The book begins by describing basic but important sample preparation protocols. It then goes on to describe more sophisticated procedures on enriching specific protein classes and concludes with detailed descriptions of integrated work-flows for comprehensive protein analysis and characterization. The authors of the individual chapters are renowned protein biochemists who have all set value to provide a detailed representation of their lab work. Throughout the chapters, these authors share important tips and tricks for a successful and reproducible employment of their protocols in other laboratories. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Proteomic Profiling: Methods and Protocols is the perfect guide for students of Biochemistry, Biomedicine, Biology, and Genomics and will be an invaluable source for the experienced, practicing scientists.

Cellular Responses To Stress

Author: C. P. Downes
Publisher: Princeton University Press
ISBN: 1400865042
Size: 16.82 MB
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Cellular Responses to Stress brings together a group of scientists who work on different but interrelated aspects of cellular stress responses. The book provides state-of-the-art information on the wide spectrum of ways in which cells can respond to different forms of stress induced by chemicals, oxidants, and DNA-damaging agents. Mechanisms are described that involve altered uptake and efflux of chemical agents, intracellular detoxification, and DNA damage responses. Many of these changes trigger a cascade of reactions mediated by stress-activated signaling pathways, which have the capacity to determine whether a cell will survive or die. The spectrum of topics covered in this book aims to provide a broad overview of our current knowledge of the different forms of adaptive response systems. It is hoped that this text will stimulate further research to establish the relative cellular role of specific response pathways and will enable us to gain a deeper understanding of the mechanisms that allow cells to live or die. This book will be valued by university researchers at all levels, industrial scientists in the pharmaceutical and biotechnology industries, and clinical researchers. Originally published in 1999. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

Genetics Evolution And Radiation

Author: Victoria L. Korogodina
Publisher: Springer
ISBN: 3319488384
Size: 55.82 MB
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This book is dedicated to the great scientist and outstanding individual Nikolay Wladimirovich Timofeeff-Ressovsky. The book brings together a number of brief stories/essays about Timofeeff-Ressovsky including “Stories told by himself”, and scientific chapters addressing his major research areas: genetics, radiobiology, radiation ecology and epidemiology, and evolution. Timofeeff-Ressovsky contributed to several fields of biology and established new directions of scientific research. He often repeated the phrase, which would later become famous: “Science should not be approached with the ferocity of wild animals”. In keeping with that philosophy, the issues discussed here are still open. Each scientific part starts with a current review; the chapters present leading scientific schools and views. The main theme discussed in the genetics part is mutation variability in the context of linear (replication, transcription, translation) and conformational template processes, and its dependence on phylogenetic group. In turn, the radiobiology chapters focus on the reorganization of DNA, cell, and population variability under low-dose irradiation, sparking indirect processes and adaptive response. The radiation ecology and epidemiology parts present data on the consequences of nuclear plants and related accidents for ecological systems and human beings. Here some approaches to estimating radiation risks are also offered. Evolution laws are demonstrated in the genomic universe, plant-microbe symbiosis, stabilizing and destabilizing (directional) selection. The last essay demonstrates the principles of organization operating in local animal populations, which are approached as social organisms of complex systemic nature. The chapter 'Radiation-Induced Aging and Genetic Instability of Mesenchymal Stem Cells: An Issue for Late Health Effects?' is available open access under a CC BY 4.0 license. div >