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Regression Methods In Biostatistics

Author: Eric Vittinghoff
Publisher: Springer Science & Business Media
ISBN: 1461413532
Size: 56.62 MB
Format: PDF, Kindle
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This new book provides a unified, in-depth, readable introduction to the multipredictor regression methods most widely used in biostatistics: linear models for continuous outcomes, logistic models for binary outcomes, the Cox model for right-censored survival times, repeated-measures models for longitudinal and hierarchical outcomes, and generalized linear models for counts and other outcomes. Treating these topics together takes advantage of all they have in common. The authors point out the many-shared elements in the methods they present for selecting, estimating, checking, and interpreting each of these models. They also show that these regression methods deal with confounding, mediation, and interaction of causal effects in essentially the same way. The examples, analyzed using Stata, are drawn from the biomedical context but generalize to other areas of application. While a first course in statistics is assumed, a chapter reviewing basic statistical methods is included. Some advanced topics are covered but the presentation remains intuitive. A brief introduction to regression analysis of complex surveys and notes for further reading are provided.

Statistical Modeling For Biomedical Researchers

Author: William D. Dupont
Publisher: Cambridge University Press
ISBN: 1139643819
Size: 28.60 MB
Format: PDF, Mobi
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The second edition of this standard text guides biomedical researchers in the selection and use of advanced statistical methods and the presentation of results to clinical colleagues. It assumes no knowledge of mathematics beyond high school level and is accessible to anyone with an introductory background in statistics. The Stata statistical software package is again used to perform the analyses, this time employing the much improved version 10 with its intuitive point and click as well as character-based commands. Topics covered include linear, logistic and Poisson regression, survival analysis, fixed-effects analysis of variance, and repeated-measure analysis of variance. Restricted cubic splines are used to model non-linear relationships. Each method is introduced in its simplest form and then extended to cover more complex situations. An appendix will help the reader select the most appropriate statistical methods for their data. The text makes extensive use of real data sets available at http://biostat.mc.vanderbilt.edu/dupontwd/wddtext/.

Primer Of Applied Regression Analysis Of Variance Third Edition

Author: Stanton A. Glantz
Publisher: McGraw Hill Professional
ISBN: 0071822445
Size: 23.49 MB
Format: PDF, ePub, Mobi
View: 2013
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A textbook on the use of advanced statistical methods in healthcare sciences Primer of Applied Regression & Analysis of Variance is a textbook especially created for medical, public health, and social and environmental science students who need applied (not theoretical) training in the use of statistical methods. The book has been acclaimed for its user-friendly style that makes complicated material understandable to readers who do not have an extensive math background. The text is packed with learning aids that include chapter-ending summaries and end-of-chapter problems that quickly assess mastery of the material. Examples from biological and health sciences are included to clarify and illustrate key points. The techniques discussed apply to a wide range of disciplines, including social and behavioral science as well as health and life sciences. Typical courses that would use this text include those that cover multiple linear regression and ANOVA. Four completely new chapters Completely updated software information and examples

Generalized Linear Mixed Models

Author: Charles E. McCulloch
Publisher: IMS
ISBN: 9780940600546
Size: 30.88 MB
Format: PDF
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Wiley Series in Probability and Statistics A modern perspective on mixed models The availability of powerful computing methods in recent decades has thrust linear and nonlinear mixed models into the mainstream of statistical application. This volume offers a modern perspective on generalized, linear, and mixed models, presenting a unified and accessible treatment of the newest statistical methods for analyzing correlated, nonnormally distributed data. As a follow-up to Searle's classic, Linear Models, and Variance Components by Searle, Casella, and McCulloch, this new work progresses from the basic one-way classification to generalized linear mixed models. A variety of statistical methods are explained and illustrated, with an emphasis on maximum likelihood and restricted maximum likelihood. An invaluable resource for applied statisticians and industrial practitioners, as well as students interested in the latest results, Generalized, Linear, and Mixed Models features: * A review of the basics of linear models and linear mixed models * Descriptions of models for nonnormal data, including generalized linear and nonlinear models * Analysis and illustration of techniques for a variety of real data sets * Information on the accommodation of longitudinal data using these models * Coverage of the prediction of realized values of random effects * A discussion of the impact of computing issues on mixed models

The Evaluation Of Surrogate Endpoints

Author: Geert Molenberghs
Publisher: Springer Science & Business Media
ISBN: 9780387202778
Size: 43.87 MB
Format: PDF, ePub, Docs
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The identification and use of surrogate endpoints, i.e., measures that can replace or supplement other endpoints in evaluations of experimental treatments or other interventions, is a general strategy that has stimulated both enthusiasm and scepticism. This book offers a balanced account on this controversial topic.

Analysis Of Observational Health Care Data Using Sas

Author: Douglas E. Faries
Publisher: SAS Institute
ISBN: 9781607644248
Size: 37.87 MB
Format: PDF, ePub, Docs
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This book guides researchers in performing and presenting high-quality analyses of all kinds of non-randomized studies, including analyses of observational studies, claims database analyses, assessment of registry data, survey data, pharmaco-economic data, and many more applications. The text is sufficiently detailed to provide not only general guidance, but to help the researcher through all of the standard issues that arise in such analyses. Just enough theory is included to allow the reader to understand the pros and cons of alternative approaches and when to use each method. The numerous contributors to this book illustrate, via real-world numerical examples and SAS code, appropriate implementations of alternative methods. The end result is that researchers will learn how to present high-quality and transparent analyses that will lead to fair and objective decisions from observational data. This book is part of the SAS Press program.

Dynamical Biostatistical Models

Author: Daniel Commenges
Publisher: CRC Press
ISBN: 1498729681
Size: 53.63 MB
Format: PDF, ePub, Mobi
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Dynamical Biostatistical Models presents statistical models and methods for the analysis of longitudinal data. The book focuses on models for analyzing repeated measures of quantitative and qualitative variables and events history, including survival and multistate models. Most of the advanced methods, such as multistate and joint models, can be applied using SAS or R software. The book describes advanced regression models that include the time dimension, such as mixed-effect models, survival models, multistate models, and joint models for repeated measures and time-to-event data. It also explores the possibility of unifying these models through a stochastic process point of view and introduces the dynamic approach to causal inference. Drawing on much of their own extensive research, the authors use three main examples throughout the text to illustrate epidemiological questions and methodological issues. Readers will see how each method is applied to real data and how to interpret the results.

Experimental Design And Data Analysis For Biologists

Author: Gerry P. Quinn
Publisher: Cambridge University Press
ISBN: 1139432893
Size: 80.91 MB
Format: PDF
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An essential textbook for any student or researcher in biology needing to design experiments, sample programs or analyse the resulting data. The text begins with a revision of estimation and hypothesis testing methods, covering both classical and Bayesian philosophies, before advancing to the analysis of linear and generalized linear models. Topics covered include linear and logistic regression, simple and complex ANOVA models (for factorial, nested, block, split-plot and repeated measures and covariance designs), and log-linear models. Multivariate techniques, including classification and ordination, are then introduced. Special emphasis is placed on checking assumptions, exploratory data analysis and presentation of results. The main analyses are illustrated with many examples from published papers and there is an extensive reference list to both the statistical and biological literature. The book is supported by a website that provides all data sets, questions for each chapter and links to software.

An Introduction To Medical Statistics

Author: Martin Bland
Publisher: OUP Oxford
ISBN: 0191002992
Size: 26.41 MB
Format: PDF, ePub, Docs
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Now in its Fourth Edition, An Introduction to Medical Statistics continues to be a 'must-have' textbook for anyone who needs a clear logical guide to the subject. Written in an easy-to-understand style and packed with real life examples, the text clearly explains the statistical principles used in the medical literature. Taking readers through the common statistical methods seen in published research and guidelines, the text focuses on how to interpret and analyse statistics for clinical practice. Using extracts from real studies, the author illustrates how data can be employed correctly and incorrectly in medical research helping readers to evaluate the statistics they encounter and appropriately implement findings in clinical practice. End of chapter exercises, case studies and multiple choice questions help readers to apply their learning and develop their own interpretative skills. This thoroughly revised edition includes new chapters on meta-analysis, missing data, and survival analysis.

Biostatistics A Computing Approach

Author: Stewart Anderson
Publisher: CRC Press
ISBN: 1584888342
Size: 26.19 MB
Format: PDF, Mobi
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The emergence of high-speed computing has facilitated the development of many exciting statistical and mathematical methods in the last 25 years, broadening the landscape of available tools in statistical investigations of complex data. Biostatistics: A Computing Approach focuses on visualization and computational approaches associated with both modern and classical techniques. Furthermore, it promotes computing as a tool for performing both analyses and simulations that can facilitate such understanding. As a practical matter, programs in R and SAS are presented throughout the text. In addition to these programs, appendices describing the basic use of SAS and R are provided. Teaching by example, this book emphasizes the importance of simulation and numerical exploration in a modern-day statistical investigation. A few statistical methods that can be implemented with simple calculations are also worked into the text to build insight about how the methods really work. Suitable for students who have an interest in the application of statistical methods but do not necessarily intend to become statisticians, this book has been developed from Introduction to Biostatistics II, which the author taught for more than a decade at the University of Pittsburgh.