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Risk Assessment And Decision Making Using Test Results

Author: V. Chankong
Publisher: Springer Science & Business Media
ISBN: 1468455958
Size: 70.67 MB
Format: PDF, Mobi
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The difficulties associated with making risk assessments on the basis of experimental results are familiar to practitioners in many fields engineering, epidemiology, chemistry, etc. These difficulties are particularly common in problems that have dynamic and stochastic characteristics driven by multiple purposes and goals, with complex interconnections and inter dependencies. Acquiring an appropriate data base, processing and analyzing model results, and transmitting these results at an appropriate technical, social, political, and institutional level are additional difficulties that must be addressed. This book is grounded on the premise that risks are best assessed on the basis of experimental results and sound mathematical analyses, coupled with the knowledge of experts. The carcinogenicity prediction and battery selection (ePBS) approach described herein provides a systematic mechan ism-a synthesis of systems and statistical and decision analyses-to aid researchers and decision makers in the critical field of carcinogenicity prediction in selecting an appropriate battery of tests to use and in translating experimental results into information that can be used as an aid to decision making.

Risk Modeling Assessment And Management

Author: Yacov Y. Haimes
Publisher: John Wiley & Sons
ISBN: 1119018013
Size: 72.56 MB
Format: PDF, Kindle
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Presents systems-based theory, methodology, and applications in risk modeling, assessment, and management This book examines risk analysis, focusing on quantifying risk and constructing probabilities for real-world decision-making, including engineering, design, technology, institutions, organizations, and policy. The author presents fundamental concepts (hierarchical holographic modeling; state space; decision analysis; multi-objective trade-off analysis) as well as advanced material (extreme events and the partitioned multi-objective risk method; multi-objective decision trees; multi-objective risk impact analysis method; guiding principles in risk analysis); avoids higher mathematics whenever possible; and reinforces the material with examples and case studies. The book will be used in systems engineering, enterprise risk management, engineering management, industrial engineering, civil engineering, and operations research. The fourth edition of Risk Modeling, Assessment, and Management features: Expanded chapters on systems-based guiding principles for risk modeling, planning, assessment, management, and communication; modeling interdependent and interconnected complex systems of systems with phantom system models; and hierarchical holographic modeling An expanded appendix including a Bayesian analysis for the prediction of chemical carcinogenicity, and the Farmer’s Dilemma formulated and solved using a deterministic linear model Updated case studies including a new case study on sequential Pareto-optimal decisions for emergent complex systems of systems A new companion website with over 200 solved exercises that feature risk analysis theories, methodologies, and application Risk Modeling, Assessment, and Management, Fourth Edition, is written for both undergraduate and graduate students in systems engineering and systems management courses. The text also serves as a resource for academic, industry, and government professionals in the fields of homeland and cyber security, healthcare, physical infrastructure systems, engineering, business, and more.

New Trends In Genetic Risk Assessment

Author: G. Jolles
Publisher: Academic Press
ISBN: 1483265676
Size: 29.58 MB
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New Trends in Genetic Risk Assessment is based on the Fifth International Round Table of the Rhône-Poulenc Santé Foundation, held in Nice 1987. The conference was an attempt to review the latest theories and mechanisms stipulated for the various aspects of genotoxicity; it was above all an open forum to discuss the new trends, the new tests, and the new battery of tests for assessing the genetic risk of chemicals and especially drugs. This volume is actually not a proceedings of the meeting but a monograph specially edited to report the reviews which were presented and the discussions which took place; it was designed to provide a better understanding of the knowledge obtained in the most recent years and to help in the practical choice of approaches or tests for the prediction of the various forms of genotoxicity. The main subjects of this review concern molecular analysis of mutagenesis, detection of DNA damage, gene mutation, clastogenesis, aneuploidy, and germ cells. Each theme is preceded by a short overview summarizing the state of the art and the contributions of each author. Finally, special attention was given to the personal views of some leading toxicologists as to the battery of tests presently available or recommended.

Environmental Risk Planning And Management

Author: Simon Gerrard
Publisher: Edward Elgar Pub
ISBN: 9781840642186
Size: 77.29 MB
Format: PDF, Kindle
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The assessment and management of risks to human health and the environment has become a topic of increasing importance and presents one of the major challenges to modern society. This comprehensive volume draws together key papers from a range of different perspectives and offers the reader an important insight into the basic principles of environmental risk management. Topics include the background to environmental risk, human health and ecological risk assessment, risk perception and communication, strategic issues in corporate environmental risk and environmental risk and siting hazardous facilities.

Comprehensive Toxicology

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Publisher:
ISBN:
Size: 14.57 MB
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Volume 14 in the series Comprehensive Toxicology extends and complements the previously published 13-volume set. This volume will be available separately. Toxicology is the study of the nature and actions of chemicals on biological systems. In more primitive times, it really was the study of poisons. However, in the early 1500s, it was apparent to Paracelsus that "the dose differentiates a poison and a remedy". Clearly, the two most important tenets of toxicology were established during that time. The level of exposure (dose) and the duration of exposure (time) will determine the degree and nature of a toxicological response. Since that time the discipline of toxicology has made major advances in identifying and characterizing toxicants. The growth of toxicology as a scientific discipline has been driven to a large extent by the use of extremely powerful molecular and cell biology techniques. The overall aim of this volume is to demonstrate how these advances are being used to elucidate causal pathways (or linkages) for potential adverse health consequences of human exposure to environmental chemicals or radiation. A unique feature of this volume is its illustration of how carefully-designed studies of the molecular mechanisms of chemical action provide not only understanding of the potential toxicity of the chemical under investigation, but also new insights into the functioning of the biological system used as an experimental model. Each chapter contains a listing of major peer-reviewed articles and reviews and useful web-sites. In addition, each chapter contains a broad introductory section that outlines the subsequent sections. These Introductory and Overview sections are designed to be stand alone chapters, and may be packaged as a textbook in graduate level courses.