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Statistical Models In Epidemiology

Author: David Clayton
Publisher: OUP Oxford
ISBN: 0191650900
Size: 29.61 MB
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This self-contained account of the statistical basis of epidemiology has been written specifically for those with a basic training in biology, therefore no previous knowledge is assumed and the mathematics is deliberately kept at a manageable level. The authors show how all statistical analysis of data is based on probability models, and once one understands the model, analysis follows easily. In showing how to use models in epidemiology the authors have chosen to emphasize the role of likelihood, an approach to statistics which is both simple and intuitively satisfying. More complex problems can then be tackled by natural extensions of the simple methods. Based on a highly successful course, this book explains the essential statistics for all epidemiologists.

Statistical Models In Epidemiology The Environment And Clinical Trials

Author: M.Elizabeth Halloran
Publisher: Springer Science & Business Media
ISBN: 1461212847
Size: 17.34 MB
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This IMA Volume in Mathematics and its Applications STATISTICAL MODELS IN EPIDEMIOLOGY, THE ENVIRONMENT,AND CLINICAL TRIALS is a combined proceedings on "Design and Analysis of Clinical Trials" and "Statistics and Epidemiology: Environment and Health. " This volume is the third series based on the proceedings of a very successful 1997 IMA Summer Program on "Statistics in the Health Sciences. " I would like to thank the organizers: M. Elizabeth Halloran of Emory University (Biostatistics) and Donald A. Berry of Duke University (Insti tute of Statistics and Decision Sciences and Cancer Center Biostatistics) for their excellent work as organizers of the meeting and for editing the proceedings. I am grateful to Seymour Geisser of University of Minnesota (Statistics), Patricia Grambsch, University of Minnesota (Biostatistics); Joel Greenhouse, Carnegie Mellon University (Statistics); Nicholas Lange, Harvard Medical School (Brain Imaging Center, McLean Hospital); Barry Margolin, University of North Carolina-Chapel Hill (Biostatistics); Sandy Weisberg, University of Minnesota (Statistics); Scott Zeger, Johns Hop kins University (Biostatistics); and Marvin Zelen, Harvard School of Public Health (Biostatistics) for organizing the six weeks summer program. I also take this opportunity to thank the National Science Foundation (NSF) and the Army Research Office (ARO), whose financial support made the workshop possible. Willard Miller, Jr.

Statistical Thinking In Epidemiology

Author: Yu-Kang Tu
Publisher: CRC Press
ISBN: 1420099922
Size: 41.45 MB
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While biomedical researchers may be able to follow instructions in the manuals accompanying the statistical software packages, they do not always have sufficient knowledge to choose the appropriate statistical methods and correctly interpret their results. Statistical Thinking in Epidemiology examines common methodological and statistical problems in the use of correlation and regression in medical and epidemiological research: mathematical coupling, regression to the mean, collinearity, the reversal paradox, and statistical interaction. Statistical Thinking in Epidemiology is about thinking statistically when looking at problems in epidemiology. The authors focus on several methods and look at them in detail: specific examples in epidemiology illustrate how different model specifications can imply different causal relationships amongst variables, and model interpretation is undertaken with appropriate consideration of the context of implicit or explicit causal relationships. This book is intended for applied statisticians and epidemiologists, but can also be very useful for clinical and applied health researchers who want to have a better understanding of statistical thinking. Throughout the book, statistical software packages R and Stata are used for general statistical modeling, and Amos and Mplus are used for structural equation modeling.


Author: Mark Woodward
Publisher: CRC Press
ISBN: 1482243202
Size: 23.13 MB
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Highly praised for its broad, practical coverage, the second edition of this popular text incorporated the major statistical models and issues relevant to epidemiological studies. Epidemiology: Study Design and Data Analysis, Third Edition continues to focus on the quantitative aspects of epidemiological research. Updated and expanded, this edition shows students how statistical principles and techniques can help solve epidemiological problems. New to the Third Edition New chapter on risk scores and clinical decision rules New chapter on computer-intensive methods, including the bootstrap, permutation tests, and missing value imputation New sections on binomial regression models, competing risk, information criteria, propensity scoring, and splines Many more exercises and examples using both Stata and SAS More than 60 new figures After introducing study design and reviewing all the standard methods, this self-contained book takes students through analytical methods for both general and specific epidemiological study designs, including cohort, case-control, and intervention studies. In addition to classical methods, it now covers modern methods that exploit the enormous power of contemporary computers. The book also addresses the problem of determining the appropriate size for a study, discusses statistical modeling in epidemiology, covers methods for comparing and summarizing the evidence from several studies, and explains how to use statistical models in risk forecasting and assessing new biomarkers. The author illustrates the techniques with numerous real-world examples and interprets results in a practical way. He also includes an extensive list of references for further reading along with exercises to reinforce understanding. Web Resource A wealth of supporting material can be downloaded from the book’s CRC Press web page, including: Real-life data sets used in the text SAS and Stata programs used for examples in the text SAS and Stata programs for special techniques covered Sample size spreadsheet

Statistical Analysis Of Epidemiologic Data

Author: Steve Selvin
Publisher: Oxford University Press
ISBN: 9780199771448
Size: 61.39 MB
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Analytic procedures suitable for the study of human disease are scattered throughout the statistical and epidemiologic literature. Explanations of their properties are frequently presented in mathematical and theoretical language. This well-established text gives readers a clear understanding of the statistical methods that are widely used in epidemiologic research without depending on advanced mathematical or statistical theory. By applying these methods to actual data, Selvin reveals the strengths and weaknesses of each analytic approach. He combines techniques from the fields of statistics, biostatistics, demography and epidemiology to present a comprehensive overview that does not require computational details of the statistical techniques described. For the Third Edition, Selvin took out some old material (e.g. the section on rarely used cross-over designs) and added new material (e.g. sections on frequently used contingency table analysis). Throughout the text he enriched existing discussions with new elements, including the analysis of multi-level categorical data and simple, intuitive arguments that exponential survival times cause the hazard function to be constant. He added a dozen new applied examples to illustrate such topics as the pitfalls of proportional mortality data, the analysis of matched pair categorical data, and the age-adjustment of mortality rates based on statistical models. The most important new feature is a chapter on Poisson regression analysis. This essential statistical tool permits the multivariable analysis of rates, probabilities and counts.

Statistical Models And Causal Inference

Author: David A. Freedman
Publisher: Cambridge University Press
ISBN: 0521195004
Size: 52.43 MB
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David A. Freedman presents a definitive synthesis of his approach to statistical modeling and causal inference in the social sciences.

Statistical Models For Proportions And Probabilities

Author: George A.F. Seber
Publisher: Springer Science & Business Media
ISBN: 3642390412
Size: 33.12 MB
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​Methods for making inferences from data about one or more probabilities and proportions are a fundamental part of a statistician’s toolbox and statistics courses. Unfortunately many of the quick, approximate methods currently taught have recently been found to be inappropriate. This monograph gives an up-to-date review of recent research on the topic and presents both exact methods and helpful approximations. Detailed theory is also presented for the different distributions involved, and can be used in a classroom setting. It will be useful for those teaching statistics at university level and for those involved in statistical consulting.

Statistics For Epidemiology

Author: Nicholas P. Jewell
Publisher: CRC Press
ISBN: 0203496868
Size: 23.93 MB
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Statistical ideas have been integral to the development of epidemiology and continue to provide the tools needed to interpret epidemiological studies. Although epidemiologists do not need a highly mathematical background in statistical theory to conduct and interpret such studies, they do need more than an encyclopedia of "recipes." Statistics for Epidemiology achieves just the right balance between the two approaches, building an intuitive understanding of the methods most important to practitioners and the skills to use them effectively. It develops the techniques for analyzing simple risk factors and disease data, with step-by-step extensions that include the use of binary regression. It covers the logistic regression model in detail and contrasts it with the Cox model for time-to-incidence data. The author uses a few simple case studies to guide readers from elementary analyses to more complex regression modeling. Following these examples through several chapters makes it easy to compare the interpretations that emerge from varying approaches. Written by one of the top biostatisticians in the field, Statistics for Epidemiology stands apart in its focus on interpretation and in the depth of understanding it provides. It lays the groundwork that all public health professionals, epidemiologists, and biostatisticians need to successfully design, conduct, and analyze epidemiological studies.

Mathematical And Statistical Estimation Approaches In Epidemiology

Author: Gerardo Chowell
Publisher: Springer Science & Business Media
ISBN: 9048123135
Size: 76.89 MB
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Mathematical and Statistical Estimation Approaches in Epidemiology compiles t- oretical and practical contributions of experts in the analysis of infectious disease epidemics in a single volume. Recent collections have focused in the analyses and simulation of deterministic and stochastic models whose aim is to identify and rank epidemiological and social mechanisms responsible for disease transmission. The contributions in this volume focus on the connections between models and disease data with emphasis on the application of mathematical and statistical approaches that quantify model and data uncertainty. The book is aimed at public health experts, applied mathematicians and sci- tists in the life and social sciences, particularly graduate or advanced undergraduate students, who are interested not only in building and connecting models to data but also in applying and developing methods that quantify uncertainty in the context of infectious diseases. Chowell and Brauer open this volume with an overview of the classical disease transmission models of Kermack-McKendrick including extensions that account for increased levels of epidemiological heterogeneity. Their theoretical tour is followed by the introduction of a simple methodology for the estimation of, the basic reproduction number,R . The use of this methodology 0 is illustrated, using regional data for 1918–1919 and 1968 in uenza pandemics.

1918 Die Welt Im Fieber

Author: Laura Spinney
Publisher: Carl Hanser Verlag GmbH Co KG
ISBN: 3446259589
Size: 73.56 MB
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Der Erste Weltkrieg geht zu Ende, und eine weitere Katastrophe fordert viele Millionen Tote: die Spanische Grippe. Binnen weniger Wochen erkrankt ein Drittel der Weltbevölkerung. Trotzdem sind die Auswirkungen auf Gesellschaft, Politik und Kultur weitgehend unbekannt. Ob in Europa, Asien oder Afrika, an vielen Orten brachte die Grippe die Machtverhältnisse ins Wanken, womöglich beeinflusste sie die Verhandlung des Versailler Vertrags und verursachte Modernisierungsbewegungen. Anhand von Schicksalen auf der ganzen Welt öffnet Laura Spinney das Panorama dieser Epoche. Sie füllt eine klaffende Lücke in der Geschichtsschreibung und erlaubt einen völlig neuen Blick auf das Schicksalsjahr 1918.