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Structural Aspects Of Protein Synthesis

Author: Mans Ehrenberg
Publisher: World Scientific
ISBN: 9814531804
Size: 65.23 MB
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This highly illustrated book provides an up-to-date description of the structure and function of the translation system including ribosomes, tRNAs, translation factors, antibiotics and aminoacyl-tRNA synthetases. Research on translation is undergoing rapid changes and is receiving significant attention as evidenced by the Nobel Prize in Chemistry 2009. The structural research by crystallography and cryo-EM forms part of an interactive framework that involves biochemistry and molecular computation. The book provides a comprehensive overview of translation in light of the structural results. It is a valuable resource for scientists in this and related fields, as well as for students taking courses with a focus on translation. There is no other book in this field currently except the previous edition of this book. The authors have for a long time worked in the field of structure and function of the translation system.Contents: The Basics of TranslationHistorical MilestonesMethods of Studying StructureThe Message ? mRNAThe Adaptor ? tRNAThe Workbench ? RibosomesThe Structure of the RibosomeRibosomal Sites and Ribosomal StatesThe Catalysts ? Translation FactorsInhibitors of Protein Synthesis ? Antibiotics, ResistanceThe Process ? TranslationProtein Processing, Folding and TargetingEvolution of the Translation Apparatus Readership: Upper level undergraduates and graduate students with an interest in protein synthesis; researchers in cell and molecular biology, biochemistry and biophysics who need to get an overview of translation.

Textbook Of Structural Biology

Author: Anders Liljas
Publisher: World Scientific
ISBN: 9812772073
Size: 61.13 MB
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A textbook for undergraduate and graduate students in structural biology, chemistry, biochemistry, biology and medicine. It covers various aspects of proteins, nucleic acids and lipids, including the rise and fall of proteins, membranes and gradients, the structural biology of cells, and evolution - the comparative structural biology.

Protein Synthesis And Ribosome Structure

Author: Knud H. Nierhaus
Publisher: John Wiley & Sons
ISBN: 3527616381
Size: 10.11 MB
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Knud Nierhaus, who has studied the ribosome for more than 30 years, has assembled here the combined efforts of several scientific disciplines into a uniform picture of the largest enzyme complex found in living cells, finally resolving many decades-old questions in molecular biology. In so doing he considers virtually all aspects of ribosome structure and function -- from the molecular mechanism of different ribosomal ribozyme activities to their selective inhibition by antibiotics, from assembly of the core particle to the regulation of ribosome component synthesis. The result is a premier resource for anyone with an interest in ribosomal protein synthesis, whether in the context of molecular biology, biotechnology, pharmacology or molecular medicine.

Cellulose Molecular And Structural Biology

Author: R. Malcolm Jr. Brown
Publisher: Springer Science & Business Media
ISBN: 1402053800
Size: 46.69 MB
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This book is an up-to-date treatise on the most advanced and provocative research into the biosynthesis, structure, and applications of Nature’s most abundant macromolecule and renewable resource, cellulose. Molecular, biochemical, and evolutionary aspects of cellulose biosynthesis are reviewed in a variety of living organisms. First hand information from the leading researchers distinguishes this work from other books on cellulose.

Protein Structure

Author: Daniel Chasman
Publisher: CRC Press
ISBN: 0824748166
Size: 76.69 MB
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This text offers in-depth perspectives on every aspect of protein structure identification, assessment, characterization, and utilization, for a clear understanding of the diversity of protein shapes, variations in protein function, and structure-based drug design. The authors cover numerous high-throughput technologies as well as computational methods to study protein structures and residues. A valuable reference, this book reflects current trends in the effort to solve new structures arising from genome initiatives, details methods to detect and identify errors in the prediction of protein structural models, and outlines challenges in the conversion of routine processes into high-throughput platforms.

Protein Nuclear Magnetic Resonance Techniques

Author: Anna Kristina Downing
Publisher: Springer Science & Business Media
ISBN: 1592598099
Size: 41.24 MB
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This second edition of Protein NMR Techniques is well written with a dynamic approach that covers multiple topics within its nineteen chapters. The text opens with a review of recombinant protein expression using two organisms, E. coli and P. pastoris that can produce high yields of isotopically labeled protein at a reasonable cost. The focus then shifts slightly to studies of aligned molecules, starting with a chapter on different options for the preparation of an aligned sample. The text also provides a comprehensive review of the use of RDCs to the study protein dynamics highlights and the range of information accessible using these methods. The book concludes with a concise explanation of the application of solid-state methods and the study of membrane proteins, a particularly important but difficult class of targets.

Molecular Mechanisms Of Protein Biosynthesis

Author: Herbert Weissbach
Publisher: Elsevier
ISBN: 0323141706
Size: 36.79 MB
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Molecular Mechanisms of Protein Biosynthesis is a collection of papers dealing with cell-free systems at the molecular level, including transfer RNA; the initiation, elongation, and termination processes; ribosome structure and function; mRNA translation; and DNA-directed in vitro protein synthesis. A couple of papers review tRNA, aminoacyl-tRNA synthetases, and aspects of ribosome structure. One paper discusses affinity labeling in the study of binding and catalytic sites of large complex and heterogeneous systems such as the ribosome. The investigator should be aware of the chemically reactive or photoactivatible analogue reacting specifically with one or more ribosomal components. This reaction should be determined if it is dependent on the correct binding of the affinity label at the functional site. Another paper describes the series of reactions in protein synthesis as the process by which the ribosome moves relative to the messenger RNA. Other papers discuss messenger RNA and its translation, DNA-dependent cell-free protein synthesis, as well as the genetics of the translational apparatus. The collection will benefit microbiologists, biotechnologists, and academicians connected with the biological sciences.

Structural Biology Of Membrane Proteins

Author: Reinhard K. Grisshammer
Publisher: Royal Society of Chemistry
ISBN: 0854043616
Size: 13.65 MB
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The book provides up-to-date reference source for researchers. Introductory sections to each topic are followed by detailed discussions for the experienced biochemist.

The Encylopedia Of Molecular Biology

Author: Sir John Kendrew
Publisher: John Wiley & Sons
ISBN: 1444313843
Size: 15.37 MB
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The Encylopaedia of Molecular Biology is a truly unique work of reference. 6000 definitions cover the entire spectrum of molecular life science The complete one-volume guide to understanding the way molecular biology is transforming medicine and agriculture Long and short entries written by over 300 of the world's finest researchers For rapid research or detailed study ... this is the A to Z of the New Biology

Membrane Proteins Production For Structural Analysis

Author: Isabelle Mus-Veteau
Publisher: Springer
ISBN: 1493906623
Size: 36.43 MB
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This book updates the latest development in production, stabilization and structural analysis techniques of membrane proteins. This field has made significant advances since the elucidation of the first 3-D structure of a recombinant G Protein Coupled Receptor (GPCR), rhodopsin, with the structure of several more GPCRs having been solved in the past five years. In fact, the 2012 Nobel Prize in Chemistry was awarded for groundbreaking discoveries on the inner workings of GPCRs. This book is essential reading for all researchers, biochemists and crystallographers working with membrane proteins, who are interested by the structural characterization of their favorite protein and who wish to follow the expression, migration, modifications and recycling of a membrane protein.