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Synthesis Of Best Seller Drugs

Author: Ruben Vardanyan
Publisher: Academic Press
ISBN: 0124115241
Size: 26.62 MB
Format: PDF, ePub
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Synthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field. Describes methods of synthesis, bioactivity and related drugs in key therapeutic areas Reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and more Presents a practical layout designed for use as a quick reference tool by those working in drug design, development and implementation

The Art Of Drug Synthesis

Author: Douglas S. Johnson
Publisher: John Wiley & Sons
ISBN: 111867846X
Size: 21.87 MB
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The Art of Drug Synthesis illustrates how chemistry, biology, pharmacokinetics, and a host of other disciplines come together to produce successful medicines. The authors have compiled a collection of 21 representative categories of drugs, from which they have selected as examples many of the best-selling drugs on the market today. An introduction to each drug is provided, as well as background to the biology, pharmacology, pharmacokinetics, and drug metabolism, followed by a detailed account of the drug synthesis. Edited by prominent scientists working in drug discovery for Pfizer Meets the needs of a growing community of researchers in pharmaceutical R&D Provides a useful guide for practicing pharmaceutical scientists as well as a text for medicinal chemistry students An excellent follow-up to the very successful first book by these editors, Contemporary Drug Synthesis, but with all new therapeutic categories and drugs discussed.

Drogen

Author: Johann Hari
Publisher: S. Fischer Verlag
ISBN: 3104035687
Size: 13.95 MB
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»Hari vereint präzise Recherche mit einer zutiefst menschlichen Erzählung. Dieses Buch wird eine dringend notwendige Debatte auslösen.« Glenn Greenwald Der Krieg gegen die Drogen gilt inzwischen als gescheitert, der Handel mit Drogen ist ein blühendes Geschäft, alle Maßnahmen gegen den Konsum sind weitgehend erfolglos. Woran liegt das? Der britische Journalist Johann Hari begibt sich auf eine einzigartige Reise – von Brooklyn über Mexiko bis nach Deutschland – und erzählt die Geschichten derjenigen, deren Leben vom immerwährenden Kampf gegen Drogen geprägt ist: von Dealern, Süchtigen, Kartellmitgliedern, den Verlierern und Profiteuren. Mit seiner grandiosen literarischen Reportage schreibt Hari sowohl eine Geschichte des Krieges gegen Drogen als auch ein mitreißendes und streitbares Plädoyer zum Umdenken. »Hervorragender Journalismus, packend erzählt.« Naomi Klein »Phantastisch!« Noam Chomsky

Hillbilly Elegie

Author: J. D. Vance
Publisher: Ullstein Buchverlage
ISBN: 3843715777
Size: 80.98 MB
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Seine Großeltern versuchten, mit Fleiß und Mobilität der Armut zu entkommen und sich in der Mitte der Gesellschaft zu etablieren. Doch letztlich war alles vergeblich. J. D. Vance erzählt die Geschichte seiner Familie — eine Geschichte vom Scheitern und von der Resignation einer ganzen Bevölkerungsschicht. Armut und Chaos, Hilflosigkeit und Gewalt, Drogen und Alkohol: Genau in diesem Teufelskreis befinden sich viele weiße Arbeiterfamilien in den USA — entfremdet von der politischen Führung, abgehängt vom Rest der Gesellschaft, anfällig für populistische Parolen. Früher konnten sich die »Hillbillys«, die weißen Fabrikarbeiter, erhoffen, sich zu Wohlstand zu schuften. Doch spätestens gegen Ende des 20sten Jahrhunderts zog der Niedergang der alten Industrien ihre Familien in eine Abwärtsspirale, in der sie bis heute stecken. Vance gelingt es wie keinem anderen, diese ausweglose Situation und die Krise einer ganzen Gesellschaft eindrücklich zu schildern. Sein Buch bewegte Millionen von Lesern in den USA und erklärt nicht zuletzt den Wahltriumph eines Donald Trump.

Top Drugs Top Synthetic Routes

Author: John Saunders
Publisher: OUP Oxford
ISBN: 9780198501008
Size: 12.30 MB
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This book will allow students to see how the organic chemistry taught in undergraduate courses is applied by medicinal chemists in industry. Many of today's best selling drugs are first made in the chemical laboratory on a very small scale many years before they enter the market place. During the intervening period, organic chemists investigate alternative methods both to improve the overall yield of the process and to ensure that it operates safely on a manufacturing scale. This book describes briefly how each drug works and then reviews the most efficient routes to their synthesis.

Contemporary Drug Synthesis

Author: Jie Jack Li
Publisher: John Wiley & Sons
ISBN: 9780471686736
Size: 70.93 MB
Format: PDF, Docs
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An integrated and insightful look at successful drug synthesis intoday's drug discovery market The pharmaceutical industry is unquestionably vibrant today,with drug synthesis making a vital contribution. Whether in theearly developmental stages of identifying and optimizing a lead, orthe latter stages of process development and cost-effectivescale-up, the ability to design elegant and economical syntheticroutes is often a major factor in the eventual viability andcommercial success of a drug. Contemporary Drug Synthesis examines how leadingresearchers and manufacturers have integrated chemistry, biology,pharmacokinetics, and a host of other disciplines in the creationand development of leading drugs. Authored by four of the pharmaceutical industry's most respectedscientists, this timely volume: Focuses on the processes that resulted in high-profile drugsincluding Lipitor, Celebrex, Viagra, Gleevec, Nexium, Claritin, andover a dozen others Provides an in-depth introduction to each drug, followed by adetailed account of its synthesis Organizes the drugs into fourteen therapeutic areas for clarityand ease of use Process chemists provide an essential bridge between chemistry andthe marketplace, creating scientifically practical drug processeswhile never losing sight of the commercial viability of thoseprocesses. Contemporary Drug Synthesis meets the needs of agrowing community of researchers in pharmaceutical research anddevelopment, and is both a useful guide for practicingpharmaceutical scientists and an excellent text for medicinal andorganic chemistry students.

The Hate U Give

Author: Angie Thomas
Publisher: cbt Verlag
ISBN: 3641200148
Size: 33.51 MB
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»Umwerfend und brillant, ein Klassiker!« Bestsellerautor John Green Die 16-jährige Starr lebt in zwei Welten: in dem verarmten Viertel, in dem sie wohnt, und in der Privatschule, an der sie fast die einzige Schwarze ist. Als Starrs bester Freund Khalil vor ihren Augen von einem Polizisten erschossen wird, rückt sie ins Zentrum der öffentlichen Aufmerksamkeit. Khalil war unbewaffnet. Bald wird landesweit über seinen Tod berichtet; viele stempeln Khalil als Gangmitglied ab, andere gehen in seinem Namen auf die Straße. Die Polizei und ein Drogenboss setzen Starr und ihre Familie unter Druck. Was geschah an jenem Abend wirklich? Die Einzige, die das beantworten kann, ist Starr. Doch ihre Antwort würde ihr Leben in Gefahr bringen...

Transition Metal Catalyzed Carbonylative Synthesis Of Heterocycles

Author: Xiao-Feng Wu
Publisher: Springer
ISBN: 3319249630
Size: 42.34 MB
Format: PDF, Kindle
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The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field. All chapters from Topics in Heterocyclic Chemistry are published Online First with an individual DOI. In references, Topics in Heterocyclic Chemistry is abbreviated as Top Heterocycl Chem and cited as a journal.

Pharmaceutical Process Chemistry For Synthesis

Author: Peter J. Harrington
Publisher: John Wiley & Sons
ISBN: 9780470922866
Size: 65.59 MB
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There is a need to explain that generic versions of a drug may not be manufactured by the same process as brand-name drugs and that the different processes may have dramatically different environmental impacts. Two global forces are at odds today—the push for "greener" processes and the push for lower drug prices. This book brings this conflict into sharp focus by discussing in detail the published process chemistry for top-selling small molecule drugs. Providing insights about process route selection, choice of reagents, and reaction conditions, Pharmaceutical Process Chemistry for Synthesis guides process chemists in identifying best processes for manufacturing these blockbuster drugs as they lose patent protection. Further, it highlights the strategies and methodology that might be useful for expediting the process research and development of the blockbusters of the future. Written from a refreshingly objective perspective, this book is essential for process chemists who need to devise practical syntheses for increasingly complex drugs in a constantly decreasing time frame.

An Introduction To Drug Synthesis

Author: Graham L. Patrick
Publisher: Oxford University Press, USA
ISBN: 0198708432
Size: 68.43 MB
Format: PDF
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'Introduction to Drug Synthesis' explores the central role played by organic synthesis in the process of drug design and development - from the generation of novel drug structures to the improved efficiency of large scale synthesis.