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Techniques And Methodological Approaches In Breast Cancer Research

Author: Jose Russo
Publisher: Springer
ISBN: 1493907182
Size: 68.34 MB
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This volume explores the myriad of techniques and methodological approaches that are being used in breast cancer research. The authors critically evaluate of the advantages and disadvantages of current methodologies, starting with the tools available for understanding the architecture of the human breast, including its tissue and cellular composition. The volume discusses the importance of functional studies in breast cancer research, especially with the help of laser capture microdissection, which allows the separation of small amounts of tissue, as well as specific cells, for biochemical analysis. In addition, the authors address methodologies including stem cell separation, which has helped in significantly understanding their role in normal breast development, but also further the understanding of breast cancer and its therapeutic management. The use of in vitro techniques and established cell lines for mechanistic studies in chemotherapeutic approaches have been invaluable will be discussed. Imaging techniques for evaluating in vitro and in vivo behavior of normal and cancerous breast tissue will be explored, as it provides a better understanding of the physiopathology of cancer. The volume will also discuss the molecular analysis of gene function in breast cancer through the transcriptomic and epigenomic profile. More importantly, the advancement of more refined techniques in sequencing will be covered. This monograph will be a comprehensive, authoritative and timely, as it addresses the emerging approaches used in breast cancer research.

Breast Cancer Research Protocols

Author: Susan A. Brooks
Publisher: Springer Science & Business Media
ISBN: 1592599699
Size: 48.47 MB
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Leading cancer researchers have assembled the most significant research protocols used by scientists in breast cancer research today. These step-by-step techniquest can be utilized to accomplish numerous scientific studies in the race to find a cure for breast cancer.

Methods In Mammary Gland Biology And Breast Cancer Research

Author: Margot M. Ip
Publisher: Springer Science & Business Media
ISBN: 1461542952
Size: 70.84 MB
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approaches to the experimental problems that still face us in understanding this most fascinating of organs. Too many people contributed to the completion of this volume to allow acknowledg ment of all the individual efforts, but we particularly thank the reviewers whose input into the editorial process was invaluable and the authors of these chapters who revised their text, sometimes more than once, to bring it to the high standards set by the Editors. The Com mittee gratefully acknowledges the support ofVysis, Inc. , in the publication of a color figure in Chapter 19, by S. Weber-Hall and Trevor Dale. Finally, we wish to express our heartfelt appreciation to Margot Ip and Bonnie Asch, who worked long and hard to bring this volume to fruition. Margaret C. Neville for the Committee on Mammary Gland Biology Preface One of the most exciting and beneficial developments in research on mammary gland biology and breast cancer has been the influx of increased funding to support this work. This influx, which has been due primarily to the tireless efforts of breast cancer activists to gamer addi tional money from various federal and state sources, has led to a rapid expansion of research efforts by attracting numerous new investigators into the field. These new investigators include students, postdoctoral fellows, and scientists from other fields.

Monoclonal Antibodies And Breast Cancer

Author: R. Ceriani
Publisher: Springer Science & Business Media
ISBN: 1461326176
Size: 77.78 MB
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Breast cancer, being a disease with very high prevalence in the female population, has permanently attracted the attention of biologists, biochemists, pathologists, surgeons, and oncologists. In the U.S. alone approximately 120,000 new cases are diagnosed and 37,000 deaths a year are recorded as an outcome. Early diagnosis, clear cut prognosis and the hope of new therapeutic approaches has spurred the enthusiasm of researchers, who with the advent of newer methodologies, tried to employ it in different approaches to the breast cancer patient. In spite of the efforts devoted towards the creation of new approaches, reagents and procedures taking advantage of special characteristics of the breast tissue were slow to come. In general, most diagnostic and prognostic techniques were those shared and applied to other carcinomas. In the early seventies we discovered the first sets of antigens associated with breast epithelial tissue both in the mouse and the human. The recognition of such group of molecules, present in the milk fat globule membrane, gave impetus to several studies in these areas. These mammary cell surface antigens proved useful in several diagnostic approaches such as radioimaging, histochemical and serum assay procedures. However, the apparently inherent limitations of polyclonal antibodies reduced the impact of these novel approaches.

Next Generation Sequencing In Cancer Research

Author: Wei Wu
Publisher: Springer Science & Business Media
ISBN: 1461476453
Size: 43.64 MB
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​​​​This volume provides an interdisciplinary perspective of applying Next Generation Sequencing (NGS) technology to cancer research. It aims to systematically introduce the concept of NGS, a variety of NGS platforms and their practical implications in cancer biology.This unique and comprehensive text will integrate the unprecedented NGS technology into various cancer research projects as opposed to most books which offer a detailed description of the technology. This volume will present true experimental results with concrete data processing pipelines, discuss the bottleneck of each platform for real project in cancer research. In additional, single cancer cell sequencing as the proof of concept will be introduced in this book, along with cutting-edge information provided will help the intended audience to develop a comprehensive understanding of the NGS technology and practical whole genome sequencing data analysis and rapidly translate into their own research, specifically in the field of cancer biology.

Breast Cancer And The Environment

Author: Committee on Breast Cancer and the Environment: The Scientific Evidence, Research Methodology, and Future Directions
Publisher: National Academies Press
ISBN: 030922070X
Size: 68.15 MB
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Breast cancer remains the most common invasive cancer among women. The primary patients of breast cancer are adult women who are approaching or have reached menopause; 90 percent of new cases in U.S. women in 2009 were diagnosed at age 45 or older. Growing knowledge of the complexity of breast cancer stimulated a transition in breast cancer research toward elucidating how external factors may influence the etiology of breast cancer. Breast Cancer and the Environment reviews the current evidence on a selection of environmental risk factors for breast cancer, considers gene-environment interactions in breast cancer, and explores evidence-based actions that might reduce the risk of breast cancer. The book also recommends further integrative research into the elements of the biology of breast development and carcinogenesis, including the influence of exposure to a variety of environmental factors during potential windows of susceptibility during the full life course, potential interventions to reduce risk, and better tools for assessing the carcinogenicity of environmental factors. For a limited set of risk factors, evidence suggests that action can be taken in ways that may reduce risk for breast cancer for many women: avoiding unnecessary medical radiation throughout life, avoiding the use of some forms of postmenopausal hormone therapy, avoiding smoking, limiting alcohol consumption, increasing physical activity, and minimizing weight gain. Breast Cancer and the Environment sets a direction and a focus for future research efforts. The book will be of special interest to medical researchers, patient advocacy groups, and public health professionals.

Methods Of Cancer Diagnosis Therapy And Prognosis

Author: M. A. Hayat
Publisher: Springer Science & Business Media
ISBN: 1402083696
Size: 30.31 MB
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The enormity of the global healthcare costs vical. One-fifth of all cancers worldwide as a result of cancer infliction cannot be are caused by a chronic infection, for overemphasized. There are more than 100 example, human papilloma virus (HPV) types of cancers; any part of the body can causes cervical cancer and hepatitis B be affected. More than 11 million people virus (HBV) causes liver cancer. Tobacco are diagnosed with cancer every year, and use is the most common preventable cause it is estimated that there will be 16 mil- of cancer in the world. Approximately, lion new cases per year by the year 2020. 168,000 cancer deaths are expected to be In 2005, 7. 6 million people died of can- caused by tobacco use. Approximately, cer, that is, 13% of the 58 million deaths 40% of cancer could be prevented, mainly worldwide. It is estimated that 9 million by not using tobacco, having a healthy people will die from cancer worldwide in diet, being physically active, preventing 2015 and 11. 4 million will die in 2030. infections that may cause cancer, reduc- More than 70% of all cancer deaths occur ing exposure to sunlight, and avoidance of in low and middle income countries. excessive alcohol consumption and stress Five major cancer causing overall mor- (anger). A third of cancers could be cured talities per year worldwide are (WHO): if detected early and treated adequately. It is well established that scientific 1. Lung: 1.

Breast Cancer

Author: Julianne S Oktay
Publisher: Routledge
ISBN: 1135418187
Size: 63.76 MB
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“I will always and forever feel I have a 'hole' in my life where my mother once existed.” “I think, when you have to think about the fact you might have to take care of your parents someday and juggle kids at the same time…It's a scary proposition.” “We had open communication during and before the breast cancer. But then after the breast cancer, I was often afraid to bring things up, in trying to protect Mom.” This insightful book tells the stories of women whose mothers had breast cancer. It uses their own voices to express the common fears and expectations of daughters in the periods before and during their mothers' illnesses, involving genetic risks, death and dying, and changes in their relationships. The case studies, tables and figures, and two appendices will benefit health professionals and counselors, while the poignant narratives will help mothers and daughters better understand their experiences with breast cancer. “I was kind of surprised to be alive and free of cancer at age 42, when at this point my mother was crippled by metastases. When I get to be 43—the age at which my mother died, or maybe when I get to 44—it's like, 'what do I do?' I have this life that I didn't expect to have.” Breast Cancer: Daughters Tell Their Stories presents the results of a qualitative, grounded theory study of breast cancer survivors, providing in-depth information about an aspect of breast cancer that has been previously overlooked. The book examines the daughters' experiences through four phases—the period prior to mother's illness, the period during mother's illness and treatment, the period following mother's death (if mother dies), and the long-term impact. From this study, recommendations are compiled for providing or improving services for tomorrow's daughters. “The radical mastectomy left her scarred and disfigured below her nightgown. It was bruised and nasty looking. That was kind of scary. I think that has terrified me since. Sometimes I'll have pains in my left breast and that's what I visualize. It's terrifying.” “I'm not really obsessed about dying of cancer. I'm more along the line of, 'If this is going to happen to me, and there's a chance it's going to, I'm gonna survive. I'm not going to die from it.” From an empathetic perspective, this book reveals how many daughters react to and deal with their mothers' diagnoses, depending on their age and family situation at the time of their mothers' illnesses. It shows how daughters can gain a more accurate idea of their level of risk by providing educational materials and developing new strategies for communication. It also helps breast cancer survivors see how their illnesses can shape their daughters' future outlook, offering new inspiration for resolving and preventing family crises.

Research Developments In Computer Vision And Image Processing Methodologies And Applications

Author: Srivastava, Rajeev
Publisher: IGI Global
ISBN: 1466645598
Size: 24.64 MB
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Similar to the way in which computer vision and computer graphics act as the dual fields that connect image processing in modern computer science, the field of image processing can be considered a crucial middle road between the vision and graphics fields. Research Developments in Computer Vision and Image Processing: Methodologies and Applications brings together various research methodologies and trends in emerging areas of application of computer vision and image processing. This book is useful for students, researchers, scientists, and engineers interested in the research developments of this rapidly growing field.