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The Laboratory Mouse

Author: Hans J. Hedrich
Publisher: Academic Press
ISBN: 0123820081
Size: 77.17 MB
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The Laboratory Mouse, Second Edition is a comprehensive book written by international experts. With inclusions of the newly revised European standards on laboratory animals, this will be the most current, global authority on the care of mice in laboratory research. This well-illustrated edition offers new and updated chapters including immunology, viruses and parasites, behavior, enrichment and care standards of laboratory mice across the life sciences, medical and veterinary fields. Features four-color illustrations with complete instruction on mouse surgery, anatomy, behavior and care of the mouse in laboratory research Offers additional chapters on new mouse strains, phenotyping of strains, bacteria and parasites, and immunology Includes the newly revised EU standards on care, as well as, comparisons to standards and regulations in the US and other countries

Handbook Of Laboratory Animal Science Volume I Third Edition

Author: Jann Hau
Publisher: CRC Press
ISBN: 9781420084566
Size: 26.82 MB
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Laboratory animal testing provides most of our current knowledge of human physiology, microbiology, immunology, pharmacology, and pathology. From studies of genetics in fruit flies to studies of cellular processes in genetically modified mice to recent dramatic developments in genetics, translational research, and personalized medicines, biomedical research involving animals remains absolutely essential for the advancement of the medical, veterinary, agricultural, and biological sciences and all rely on access to high-quality laboratory animals as models for humans. Rooted in the principle that good science can only be performed in environments that promote good animal welfare, this third edition of the bestselling Handbook of Laboratory Animal Science, Vol. 1, Essential Principles and Practices emphasizes the importance of implementing the three R’s: replacing live animals with alternative methods, reducing the number of animals used, and refining techniques to minimize animal discomfort, and integrates these humane principles into almost every chapter. See what's new in the Third Edition: New chapters: Applications of Radio-Telemetry in Small Laboratory Animals, Generation and analysis of genetically modified mice, and Physiological, Hematological, and Clinical Chemistry Parameters Additional mateiral on the international harmonization of practices and on the continued implementation of the refinement, reduction, and replacement of animal usage in laboratories Sixteen page color insert Relevant to virtually all areas of laboratory science and forming the cornerstone of laboratory animal science, each individual chapter focuses on an important subdiscipline of laboratory animal science including humane laws and guidelines; non-surgical, surgical, microsurgical, and post-mortem procedures; genetic modification; nutrition, feeding, and environmental factors; experiment design and alternative methods; and analgesia, anesthesia, and euthanasia. Each chapter can be read in series or as a stand alone text. A truly international effort from world renowned contributors, Handbook of Laboratory Animal Science, Vol. 1, Essential Principles and Practices, Third Edition is useful as a textbook in laboratory animal science courses for postgraduate and undergraduate students, as a handbook for scientists who work with animals in their research, and for university veterinarians, regulators, and other specialists in laboratory animal science.

Pharmakotherapie Bei Haus Und Nutztieren

Author: Wolfgang Löscher
Publisher: Georg Thieme Verlag
ISBN: 3830412525
Size: 18.12 MB
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Welches Analgetikum passt zu meinem Patienten? Mit welchen Nebenwirkungen muss ich rechnen? Und in welchem Fall sollte ich von der Verwendung Abstand nehmen? Gründlich überarbeitet und um neue Arzneimittel ergänzt, liefert dieses Buch alle praxisrelevanten Informationen über zugelassene Medikamente bei Haus- und Nutztieren. Die Wirkstoff e sind übersichtlich untergliedert in Präparate, Dosierungen, Wirkmechanismus, Anwendungsgebiete, Tierartenunterschiede, Nebenwirkungen und Wartezeiten. NEU: Jetzt auch mit Medikamenten für Fische und kleine Wiederkäuer. Das Standardwerk für Kleintier- und Großtierpraktiker sowie für Studierende. Bereits in 9. Auflage!

A Handbook Of Mouse Models Of Cardiovascular Disease

Author: Qingbo Xu
Publisher: John Wiley & Sons
ISBN: 0470028785
Size: 21.20 MB
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The availability of well-defined genetic strains and the ability to create transgenic and knockout mice makes mouse models extremely valuable biomedical tools. Their suitability as an experimental system for cardiovascular research depends on the individual investigator’s ability to manipulate the mice surgically. Many mouse models require microsurgical techniques, which hitherto could not be performed without practical training. This comprehensive handbook enables scientists to develop these models in their own laboratories. A Handbook of Mouse Models of Cardiovascular Disease is the first book to address pathology in mouse models of heart disease, providing the reader with essential information on technical assays in artificially created models. It includes background information on individual cardiovascular diseases, describes detailed methods and materials used for establishing each mouse model, discusses the problems that may appear in the experiments, and provides examples of applications of the model. A Handbook of Mouse Models of Cardiovascular Disease: Describes mouse models of all important cardiovascular diseases, including atherosclerosis, atrial fibrillation and thrombosis Features videos of key experimental procedures on the accompanying CD, allowing researchers to learn the techniques by directly watching the whole operational procedure Describes how to establish each experimental model with detailed protocols and tips on dealing with common operational problems Highlights potential applications of each model in areas such as pathogenesis, gene transfer, therapy and pathophysiology This handbook is an invaluable resource for researchers in cardiovascular disease, pathology, physiology, interested in the mechanism of vascular disorders and therapeutic approaches. It is also relevant to clinicians seeking to understand the pathology of cardiovascular disease and the rationale for interventions, and of interest to the pharmaceutical industry and all those involved in drug discovery/development for cardiovascular disease.

Genetically Engineered Mice Handbook

Author: John P. Sundberg
Publisher: CRC Press
ISBN: 1420039075
Size: 72.35 MB
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While mice have always been highly popular laboratory subjects, their suitability for genetic engineering has solidified their position as today's lab animal model of choice. However, their increased use in genetic studies has created a demand for input on phenotyping that is not always easily met. To improve the flow of information on the pathology of mice with spontaneous or genetically engineered mutations, prominent researchers organized a series of meetings. Recognizing other needs, the organizers gradually broadened their focus, until finally they expanded to provide an overview of the entire field of genetically engineered models. The Genetically Engineered Mice Handbook is an extension of those meetings. It offers an introduction for those entering into this area of research, while also serving as a resource for those presently employing mice as laboratory models. Highly comprehensive, this volume covers pertinent aspects of genetically engineered mice, including the use of models for developmental biology and the monitoring of laboratory colonies. With contributions from nearly five-dozen leading researchers, the text presents systematic approaches for analyzing mutant mice for specific medical applications, details a variety of methods for creating mutants and includes information that is particularly hard to access dealing with legal responsibilities. This essential reference examines commonly used traditional, as well as emerging, technologies To address the purpose of the original meeting, the Genetically Engineered Mice Handbook directs researchers to the best public websites, and offers instruction on how to use them. In the past, as their work dictated, researchers would seek out experts on particular organ systems. Now groups of experts work together to generate these websites, providing the latest data as well as discussions over points of debate. These sites do not eliminate the need for a trained pathologist, but they do provide reference materials for those lacking expertise in particular anatomic structures. They also offer much greater numbers of examples than are available in print, from which biomedical researchers can draw.

Der Erfolg Durch Therapiehunde Bei Kindern Mit Adhs Syndrom Hundegest Tzte P Dagogik Als M Gliche Intervention

Author: Simon Bransch
Publisher: Diplomica Verlag
ISBN: 3842892330
Size: 62.83 MB
Format: PDF
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Das große Interesse am ADHS-Syndrom und den damit einhergehenden Auffälligkeiten in unserer Gesellschaft führen zu einem ständigen Diskussionsstoff gerade in Bezug auf die Therapierbarkeit dieser Erkrankung. Tiergestützte Interventionen, an denen das Interesse fortwährend zunimmt und deren Angebote in Deutschland immer zahlreicher werden, bieten eine alternative Möglichkeit, ADHS-Kinder zu therapieren. Das vorliegende Buch stellt hinsichtlich dieser Tatsache einen theoretischen Querschnitt der beiden Themenkomplexe ADHS und tiergestützte Intervention dar und widmet sich der Wirksamkeit hundgestützter Pädagogik als Form der tiergestützten Intervention in einer exemplarischen Fallstudie. In dieser Fallstudie werden vier Sitzungen einer hundgestützten Therapie begleitet, um deren Kurzzeiteffekte zu evaluieren.


Author: Reinhard Richardi
ISBN: 9783406635434
Size: 46.70 MB
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The Iacuc Handbook Third Edition

Author: Jerald Silverman
Publisher: CRC Press
ISBN: 1466555645
Size: 62.14 MB
Format: PDF
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Ever since its establishment by USDA regulation in the mid-1980s, the Institutional Animal Care and Use Committee (IACUC) has evolved as the premier instrument of animal welfare oversight within research institutions in the United States. As biomedical research continuously grows, the role and impact of the IACUC has increased in scope and complexity. The IACUC Handbook has become "the Bible" for individuals when the time comes for them to serve on their institution’s IACUC. It provides a foundation for understanding and implementing the many and varied responsibilities of this committee. This Third Edition comprehensively addresses the significant changes in the pertinent regulatory environment and interpretation of applicable federal laws, regulations, and policies. It provides multiple references and commentary on the new edition of the Guide for the Care and Use of Laboratory Animals, the new AVMA Guidelines for the Euthanasia of Animals: 2013 Edition, and the Office of Laboratory Animal Welfare’s Frequently Asked Questions. The Third Edition also features an updated survey of IACUC practices from institutions around the United States, offering wisdom gained from their experience. In addition, it includes a chapter that provides an international perspective on how animal welfare reviews can function in other countries.