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The Laboratory Mouse Second Edition

Author: Peggy J. Danneman
Publisher: CRC Press
ISBN: 1439854211
Size: 53.98 MB
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Mice have long been recognized as a valuable tool for investigating the genetic and physiological bases of human diseases such as diabetes, infectious disease, cancer, heart disease, and a wide array of neurological disorders. With the advent of transgenic and other genetic engineering technologies, the versatility and usefulness of the mouse as a model in biomedical research has soared. As a result, mouse colonies everywhere are expanding, and scientists who previously focused on other models are turning their attention to the mouse. Revised to reflect advances since the first edition, The Laboratory Mouse, Second Edition continues to be the most accessible reference on the biology and care of the laboratory mouse. This guide presents basic information and common procedures in detail to provide a quick reference source for investigators, technicians, and caretakers in the humane care and use of the mouse in the laboratory setting. Expanded, updated, and now in color, this new edition includes coverage of the biological features, husbandry, management, veterinary care, experimental methodology, and resources applying specifically to the mouse.

The Laboratory Mouse

Author: Hans J. Hedrich
Publisher: Academic Press
ISBN: 0123820081
Size: 79.84 MB
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The Laboratory Mouse, Second Edition is a comprehensive book written by international experts. With inclusions of the newly revised European standards on laboratory animals, this will be the most current, global authority on the care of mice in laboratory research. This well-illustrated edition offers new and updated chapters including immunology, viruses and parasites, behavior, enrichment and care standards of laboratory mice across the life sciences, medical and veterinary fields. Features four-color illustrations with complete instruction on mouse surgery, anatomy, behavior and care of the mouse in laboratory research Offers additional chapters on new mouse strains, phenotyping of strains, bacteria and parasites, and immunology Includes the newly revised EU standards on care, as well as, comparisons to standards and regulations in the US and other countries

Critical Care Management For Laboratory Mice And Rats

Author: F. Claire Hankenson
Publisher: CRC Press
ISBN: 0849324998
Size: 80.25 MB
Format: PDF
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For critical care of laboratory rodents, there is a scarcity of sources for comprehensive, feasible, and response-oriented information on clinical interventions specific to spontaneous and induced models of disease. With the more complex cases that need critical care management, many treatment approaches to veterinary emergencies cannot be applied directly to the laboratory rodent. The first text of its kind devoted to the challenges of critical care management for laboratory rodents, Critical Care Management for Laboratory Mice and Rats provides a specialized resource for all veterinary, husbandry, technical, and research professionals who utilize rodent models for biomedical research. The book covers the varied approaches to laboratory rodent patient care, health assessments, characteristics of specific disease models, monitoring and scoring of disease parameters, and humane interventions. Giving primary consideration to preservation of animal health and welfare, the text also considers how best to balance welfare with the achievement of proposed scientific objectives. Organized into five chapters, this full-color book covers the following topics: General Approaches for Critical Care Critical Care Management for Laboratory Mice Critical Care Management for Laboratory Rats Special Considerations for Critical Care Management in Laboratory Rodents Resources and Additional Information The author provides treatment guidelines with the expectation that they will be applied with apt professional judgment, allowing for further modification of clinical recommendations for improved patient-based care and welfare for research animals.

The Mouse In Biomedical Research

Author:
Publisher: Elsevier
ISBN: 9780080469072
Size: 11.86 MB
Format: PDF, Kindle
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Normative Biology, Husbandry, and Models, the third volume in the four volume set, The Mouse in Biomedical Research, encompasses 23 chapters whose contents provide a broad overview on the laboratory mouse’s normative biology, husbandry, and its use as a model in biomedical research. This consists of chapters on behavior, physiology, reproductive physiology, anatomy, endocrinology, hematology, and clinical chemistry. Other chapters cover management, as well as nutrition, gnotobiotics and disease surveillance. There are also individual chapters describing the mouse as a model for the study of aging, eye research, neurodegenerative diseases, convulsive disorders, diabetes, and cardiovascular and skin diseases. Chapters on imaging techniques and the use of the mouse in assays of biological products are also included.

The Laboratory Mouse

Author: Peggy J. Danneman
Publisher: CRC Press
ISBN: 9780849303227
Size: 23.98 MB
Format: PDF
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Mice have been domesticated by humans for centuries, even millennia, and have been used in research since the 1600's. However, development of the laboratory mouse as a research model accelerated with genetic experiments in the early 1900's. Today, the laboratory mouse is recognized as the pre-eminent model for modern genetic research. In fact, over the last decade or so, most biomedical research facilities have experienced increases of up to three hundred percent in their mouse populations. Numerous other disciplines, including immunology, cancer biology, toxicology, developmental biology, aging research, and cardiovascular biology have recognized the mouse as a valuable research model. The Laboratory Mouse provides a single source reference for investigators, technicians, and animal caretakers charged with the care and/or use of mice in biomedical research. The book is particularly valuable to researchers at small institutions and to those who work at facilities that lack large, well-organized animal resource units.

Handbook Of Laboratory Animal Science Second Edition

Author: Jann Hau
Publisher: CRC Press
ISBN: 9780849343780
Size: 14.13 MB
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This two-volume set presents a comprehensive description of laboratory animal genetics, diseases, health monitoring, nutrition, and the environmental impact on animal testing. It considers the ethics of animal experimentation through a complete review of European and North American legislation on the topic. It discusses alternatives to animal experiments, including the use of isolated organs, cell cultures, and computer simulations. The book also examines general methods, including experimental design and statistical evaluation, non-surgical and surgical techniques, anesthesia, and post-mortem examinations. Reviews of animal models for studying diseases of different organ systems, infectious diseases, cancer, and toxicology are featured as well.

The Laboratory Rat

Author: Mark A. Suckow
Publisher: Elsevier
ISBN: 9780080454320
Size: 80.99 MB
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The Laboratory Rat, Second Edition features updated information on a variety of topics including: rat genetics and genomics, both spontaneous and induced disease; state-of-the-art technology for housing and husbandry; occupational health, and experimental models. A premier source of information on the laboratory rat that will be of interest to veterinary and medical students, senior graduate, graduate students, post-docs and researchers who utilize animals in biomedical research. At least 50% new information than first edition Includes topics on rat genetics and genomics, occupational health, and experimental models The premier source of information on the laboratory rat

The Mouse In Biomedical Research

Author: Henry Foster
Publisher: Elsevier
ISBN: 0323156061
Size: 73.20 MB
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The Mouse in Biomedical Research, Volume I: History, Genetics, and Wild Mice focuses on the utility of the mouse as a laboratory animal in biomedical research. A historical perspective on the development and origins of the laboratory and wild mouse is given. The diversity of inbred strains of mice as well as the methods of developing and the genetic monitoring and testing of these strains are discussed. This volume consists of 14 chapters and begins with an overview of mice of the genus Mus and problems concerning evolution within the genus. The following chapters focus on taxonomy, nomenclature, and breeding systems, together with recombinant inbred and congenic resistant mouse strains. Methods of constructing, testing, and monitoring strains are described. Congenic strains, gene mapping, cytogenetics, and murine experimental studies are also considered, along with the histocompatibility-2 complex and radiation genetics. The final chapter is devoted to the pharmacogenetics of the laboratory mouse, paying particular attention to intoxication and detoxication pathways, genetically determined differences in xenobiotic metabolism, and pharmacogenetic polymorphisms. This book will be a useful reference for investigators using mice in many areas of research.

Diseases

Author: Henry L. Foster
Publisher: Academic Press
ISBN: 1483269132
Size: 65.59 MB
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The Mouse in Biomedical Research, Volume II: Diseases is a compilation of papers detailing infectious diseases of the mouse. This compilation deals with bacterial, mycotic, viral, protozoal, rickettsial, parasitic, non-neoplastic, and metabolic diseases of the mouse. Several papers describe the different diseases found in the digestive, respiratory, urogenital, integumentary, central nervous, lymphoreticular, musculoskeletal, cardiovascular, and endocrine systems of the mouse. This book lists the possible bacterial infections, as well as other miscellaneous infections such as those caused by aerosols, particles, and the air in the laboratory environment. This text also lists viruses that can affect the mouse such as the lactate dehydrogenase-elevating virus, mouse pox, polyomavirus, and the minute virus. This book describes the process of identification, diagnosis, epidemiology, treatment, control, prevention, and occurrence of these diseases. This text also reviews the diseases that can be transmitted from infected mice to humans, as well as through animal bites and allergic reactions. This book is suitable for researchers, clinical assistants, and scientists dealing with laboratory animals, particularly with mice as test animals. This book can also be helpful for veterinarians and doctors of infectious diseases transferred from animals.