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The Mouse In Biomedical Research

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Publisher: Elsevier
ISBN: 9780080469072
Size: 10.94 MB
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Normative Biology, Husbandry, and Models, the third volume in the four volume set, The Mouse in Biomedical Research, encompasses 23 chapters whose contents provide a broad overview on the laboratory mouse’s normative biology, husbandry, and its use as a model in biomedical research. This consists of chapters on behavior, physiology, reproductive physiology, anatomy, endocrinology, hematology, and clinical chemistry. Other chapters cover management, as well as nutrition, gnotobiotics and disease surveillance. There are also individual chapters describing the mouse as a model for the study of aging, eye research, neurodegenerative diseases, convulsive disorders, diabetes, and cardiovascular and skin diseases. Chapters on imaging techniques and the use of the mouse in assays of biological products are also included.

Nonhuman Primates In Biomedical Research Diseases

Author: Christian R. Abee
Publisher: Academic Press
ISBN: 0123813662
Size: 44.94 MB
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A comprehensive, up-to-date review of the use of nonhuman primates in biomedical research, emphasising the biology and management, diseases, and biomedical models for nonhuman primate species most commonly used in research.

The Mouse In Biomedical Research

Author: Henry Foster
Publisher: Elsevier
ISBN: 0323156061
Size: 74.78 MB
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The Mouse in Biomedical Research, Volume I: History, Genetics, and Wild Mice focuses on the utility of the mouse as a laboratory animal in biomedical research. A historical perspective on the development and origins of the laboratory and wild mouse is given. The diversity of inbred strains of mice as well as the methods of developing and the genetic monitoring and testing of these strains are discussed. This volume consists of 14 chapters and begins with an overview of mice of the genus Mus and problems concerning evolution within the genus. The following chapters focus on taxonomy, nomenclature, and breeding systems, together with recombinant inbred and congenic resistant mouse strains. Methods of constructing, testing, and monitoring strains are described. Congenic strains, gene mapping, cytogenetics, and murine experimental studies are also considered, along with the histocompatibility-2 complex and radiation genetics. The final chapter is devoted to the pharmacogenetics of the laboratory mouse, paying particular attention to intoxication and detoxication pathways, genetically determined differences in xenobiotic metabolism, and pharmacogenetic polymorphisms. This book will be a useful reference for investigators using mice in many areas of research.

Laboratory Animal Medicine

Author: James G. Fox
Publisher: Academic Press
ISBN: 1483269167
Size: 41.54 MB
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Laboratory Animal Medicine is a compilation of papers that deals with the diseases and biology of major species of animals used in medical research. The book discusses animal medicine, experimental methods and techniques, design and management of animal facilities, and legislation on laboratory animals. Several papers discuss the biology and diseases of mice, hamsters, guinea pigs, and rabbits. Another paper addresses the dog and cat as laboratory animals, including sourcing of these animals, housing, feeding, and their nutritional needs, as well as breeding and colony management. The book also describes ungulates as laboratory animals, including topics on sourcing, husbandry, preventive medical treatments, and housing facilities. One paper addresses primates as test animals, covering the biology and diseases of old world primates, Cebidae, and ferrets. Some papers pertain to the treatment, diseases, and needed facilities for birds, amphibians, and fish. Other papers then deal with techniques of experimentation, anesthesia, euthanasia, and some factors (spontaneous diseases) that complicate animal research. The text can prove helpful for scientists, clinical assistants, and researchers whose work involves laboratory animals.

Diseases

Author: Henry L. Foster
Publisher: Academic Press
ISBN: 1483269132
Size: 23.71 MB
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The Mouse in Biomedical Research, Volume II: Diseases is a compilation of papers detailing infectious diseases of the mouse. This compilation deals with bacterial, mycotic, viral, protozoal, rickettsial, parasitic, non-neoplastic, and metabolic diseases of the mouse. Several papers describe the different diseases found in the digestive, respiratory, urogenital, integumentary, central nervous, lymphoreticular, musculoskeletal, cardiovascular, and endocrine systems of the mouse. This book lists the possible bacterial infections, as well as other miscellaneous infections such as those caused by aerosols, particles, and the air in the laboratory environment. This text also lists viruses that can affect the mouse such as the lactate dehydrogenase-elevating virus, mouse pox, polyomavirus, and the minute virus. This book describes the process of identification, diagnosis, epidemiology, treatment, control, prevention, and occurrence of these diseases. This text also reviews the diseases that can be transmitted from infected mice to humans, as well as through animal bites and allergic reactions. This book is suitable for researchers, clinical assistants, and scientists dealing with laboratory animals, particularly with mice as test animals. This book can also be helpful for veterinarians and doctors of infectious diseases transferred from animals.