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The Organic Chemistry Of Drug Design And Drug Action

Author: Richard B. Silverman
Publisher: Academic Press
ISBN: 0123820316
Size: 18.21 MB
Format: PDF, ePub
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The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. Updates to all chapters, including new examples and references Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry Chapter 3 (Receptors): Drug-receptor interactions, cation-π and halogen bonding; atropisomers; case history of the insomnia drug suvorexant Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates


Author: Alfred Ruland
Publisher: Walter de Gruyter GmbH & Co KG
ISBN: 3110423588
Size: 41.87 MB
Format: PDF, Mobi
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Dieses Buch ist Teil unserer neuen Datenbank Anorganik Online. Das traditionsreiche Lehrbuch von Küster und Thiel, früher "Rechentafeln für die Chemische Analytik" ist eine umfassende Sammlung der wichtigsten Methoden und Daten der analytischen Chemie und ein unersetzliches Nachschlagewerk für die Arbeit im Labor. Neben zahlreichen Tabellen findet der Leser nun auch eine große Zahl an Erklärungen und Beispielen, inklusive detailliert beschriebener Berechnungen, die die Nutzung des Werkes stark vereinfachen.

Drug Design And Action

Author: Joaquín M. Campos Rosa
Publisher: Walter de Gruyter GmbH & Co KG
ISBN: 3110528487
Size: 18.11 MB
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This two volume book is an excellent introduction to this interdisciplinary area, lying on the interface between organic chemistry, biochemistry and medicine. The authors give a comprehensive overview of the field and outline the actual challenges in pharmaceutical science and industry. Volume 1 introduces the concepts of drug design and drug metabolic processes as well as antibacterial, antiviral and anticancer agents.

Textbook Of Drug Design And Discovery Third Edition

Author: Tommy Liljefors
Publisher: CRC Press
ISBN: 9780415282888
Size: 38.82 MB
Format: PDF, ePub, Mobi
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Building on the success of the previous editions, Textbook of Drug Design and Discovery has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The book follows drug design from the initial lead identification through optimization and structure-activity relationship with reference to the final processes of clinical evaluation and registration. Chapters investigate the design of enzyme inhibitors and drugs for particular cellular targets such as ion channels and receptors, and also explore specific classes of drug such as peptidomimetics, antivirals and anticancer agents. The use of gene technology in pharmaceutical research, computer modeling techniques, and combinatorial approaches are also included.

The Organic Chemistry Of Drug Design And Drug Action Power Pdf

Author: Richard B. Silverman
Publisher: Elsevier
ISBN: 0080575382
Size: 54.17 MB
Format: PDF, ePub
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This CD-ROM edition of Silverman's Organic Chemisry of Drug Design and Drug Action, Second Edition reflects the significant changes in the drug industry in recent years, using an accessible interactive approach. This CD-ROM integrates the author's own PowerPoint slides, indexed and linked to the book pages in PDF format. The three-part structure includes an all-electronic text with full-text search capabilites and nearly 800 powerpoint slides. This is a unique and powerful combination of electronic study guide and full book pages. Users can hyperlink seamlessly from the main text to key points and figures on the outline and back again. It serves as a wonderful supplement for instructors as well as a fully integrated text and study aid for students. * Three-part package includes 1) powerpoint, 2) integrated powerpoint and pdf-based text, and 3) fully searchable PDF-based text with index * Includes new full-color illustrations, structures, schemes, and figures as well as extensive chapter problems and exercises * User-friendly buttons transition from overview (study-guide) format to corresponding book page and back with the click of a mouse * Full-text search capabality an incomparable tool for researchers seeking specific references and/or unindexed phrases


Author: Werner Massa
Publisher: Springer-Verlag
ISBN: 3835190938
Size: 60.59 MB
Format: PDF
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In anschaulicher Form - unterstützt durch zahlreiche Abbildungen - führt dieses Lehrbuch in die Kristallstrukturbestimmung ein. Die kristallographischen Grundlagen und einzelne praktische Schritte der modernen Kristallstrukturbestimmung werden verständlich und nachvollziehbar erklärt.

Grundlagen Der Festk Rperchemie

Author: Anthony R. West
Publisher: Wiley-VCH
ISBN: 9783527281039
Size: 31.47 MB
Format: PDF, Kindle
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Die Festkörperchemie, längst eine interdisziplinäre Wissenschaft, ist heute auch für Studierende der Chemie zunehmend wichtig. Herkömmliche Lehrbücher der Anorganischen Chemie tragen dieser Entwicklung jedoch bisher kaum Rechnung. Dieses Buch schafft hier Abhilfe. Knapp, doch gründlich und umfassend beschreibt es die Grundlagen der Festkörperchemie: * Kristallsysteme und Strukturtypen * Bindung in Festkörpern * Defekte * Phasendiagramme * Strukturaufklärung. Dabei werden neben klassischen Beugungsmethoden auch moderne Verfahren wie z.B. Mikroskopie, NMR, EPR und Elektronenspektroskopie intensiv behandelt. Schließlich schafft dieses Buch eine Basis für das Verständnis aktueller Schlagworte wie Organische Metalle, Supraleiter und Laser und damit die Voraussetzung für einen tieferen Einstieg in dieses dynamische Gebiet und seine Nachbardisziplinen.