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The Physiology Of Bioelectricity In Development Tissue Regeneration And Cancer

Author: Christine E. Pullar
Publisher: CRC Press
ISBN: 9781439837245
Size: 11.60 MB
Format: PDF
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Recent advances in technology have led to the unprecedented accuracy in measurements of endogenous electric fields around sites of tissue disruption. State-of-the-art molecular approaches demonstrate the role of bioelectricity in the directionality and speed of cell migration, proliferation, apoptosis, differentiation, and orientation. New information indicates that electric fields play a role in initiating and coordinating complex regenerative responses in development and wound repair and that they may also have a part in cancer progression and metastasis. Compiling current research in this rapidly expanding field, Physiology of Bioelectricity in Development, Tissue Regeneration, and Cancer highlights relevant, cutting-edge topics poised to drive the next generation of medical breakthroughs. Chapters consider methods for detecting endogenous electric field gradients and studying applied electric fields in the lab. The book addresses bioelectricity’s roles in guiding cell behavior during morphogenesis and orchestrating higher order patterning. It also covers the response of stem cells to applied electric fields, which reveals bioelectricity as an exciting new player in tissue engineering and regenerative medicine. This book provides an in-depth exploration of how electric signals control corneal wound repair and skin re-epithelialization, angiogenesis, and inflammation. It also delves into the bioelectric responses of cells derived from the musculoskeletal system, bioelectrical guidance of neurons, and the beneficial application of voltage gradients to promote regeneration in the spinal cord. It concludes with a discussion of bioelectricity and cancer progression and the potential for novel cancer biomarkers, new methods for early detection, and bioelectricity-based therapies to target both the tumor and metastatic cancer cells. This multidisciplinary compilation will benefit biologists, biochemists, biomedical scientists, engineers, dermatologists, and clinicians, or anyone else interested in development, regeneration, cancer, and tissue engineering. It can also serve as an ideal textbook for students in biology, medicine, medical physiology, biophysics, and biomedical engineering.

Regenerative Engineering And Developmental Biology

Author: David M. Gardiner
Publisher: CRC Press
ISBN: 1351646494
Size: 25.48 MB
Format: PDF, Kindle
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Regenerative Engineering and Developmental Biology: Principles and Applications examines cutting-edge developments in the field of regenerative engineering. Specific attention is given to activities that embrace the importance of integrating developmental biology and tissue engineering, and how this can move beyond repairing damage to body parts to instead regenerate tissues and organs. The text furthermore focusses on the five legs of the field of regenerative engineering, including: materials, developmental biology, stem cells, physics, and clinical translation. This book was written by leading developmental biologists; each chapter examines the processes that these biologists study and how they can be advanced by using the tools available in tissue engineering/biomaterials. Individual chapters are complete with concluding remarks and thoughts on the future of regenerative engineering. A list of references is also provided to aid the reader with further research. Ultimately, this book achieves two goals. The first encourages the biomedical community to think about how inducing regeneration is an engineering problem. The second goal highlights the discoveries with animal regeneration and how these processes can be engineered to regenerate body parts. Regenerative Engineering and Developmental Biology: Principles and Applications was written with undergraduate and graduate-level biomedical engineering students and biomedical professionals in mind.

Advanced Electroporation Techniques In Biology And Medicine

Author: Andrei G. Pakhomov
Publisher: CRC Press
ISBN: 1439819076
Size: 41.68 MB
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A reflection of the intense study of the effects of electromagnetic fields on living tissues that has taken place during the last decades, Advanced Electroporation Techniques in Biology and Medicine summarizes most recent experimental findings and theories related to permeabilization of biomembranes by pulsed electric fields. Edited by experts and including contributions from pioneers in the field, the book focuses on biophysical mechanisms of electroporation and applications of this phenomenon in biomedical research and medicine. The field of electroporation is now mature enough to move from journal pages to book covers. The book leads readers from the basics and history of electroporation, through mechanisms of membrane permeabilization in lipid bilayers and living cells, to electrically-mediated gene delivery and cancer therapy in animals and humans. This book is an interdisciplinary compilation intended broadly for biomedical and physical scientists, engineers, and clinicians. It can also be used as a textbook for students in advanced courses in biomedical engineering, molecular and cell biology, as well as in biophysics and clinical medicine.

Electromagnetic Fields In Biological Systems

Author: James C. Lin
Publisher: CRC Press
ISBN: 1439860629
Size: 66.72 MB
Format: PDF
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As wireless technology becomes more sophisticated and accessible to more users, the interactions of electromagnetic fields with biological systems have captured the interest not only of the scientific community but also the general public. Unintended or deleterious biological effects of electromagnetic fields and radiation may indicate grounds for health and safety precautions in their use. Spanning static fields to terahertz waves, Electromagnetic Fields in Biological Systems explores the range of consequences these fields have on the human body. With contributions by an array of experts, topics discussed include: Essential interactions and field coupling phenomena, highlighting their importance in research on biological effects and in scientific, industrial, and medical applications Electric field interactions in cells, focusing on ultrashort, pulsed high-intensity fields The effect of exposure to naturally occurring and human-made static, low-frequency, and pulsed magnetic fields in biological systems Dosimetry or coupling of extremely low frequency (ELF) fields into biological systems and the historical developments and recent trends in numerical dosimetry Mobile communication devices and the dosimetry or coupling of radiofrequency (RF) radiation into the human body Exposure and dosimetry associated with magnetic resonance imaging (MRI) and spectroscopy Available data on the interaction of terahertz radiation with biological tissues, cells, organelles, and molecules There is great potential for communication, industrial, scientific, and medical use of electromagnetic fields and radiation. To help advance knowledge of the biological effects of such fields and to exploit their potential medical applications, this book highlights critical issues relating to their effects on living systems.

Epidemiology Of Electromagnetic Fields

Author: Martin Roosli
Publisher: CRC Press
ISBN: 146656816X
Size: 31.75 MB
Format: PDF, ePub, Docs
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Appeals to a Wide Audience Fueled by more than 30 years of intensive research and debate on the impact of electromagnetic fields (EMF) on everyday life—starting with residential exposure to magnetic fields and the development of childhood cancer in the 70s and continuing with risk of exposure via wireless communications in present day—Epidemiology of Electromagnetic Fields addresses ongoing public and scientific controversy surrounding the possible effects of electromagnetic fields (EMF) to human health, and provides an in-depth introduction into the methodology of environmental epidemiology that is appropriate for all levels, from student to practicing engineer. Exposure to EMF Focusing primarily on EMF examples, the author presents the general principles and methodological concepts in environmental epidemiology. Topics of importance in the first part of the book include epidemiological study designs, exposure assessment methods and implications for the study results, as well as selection bias, confounding, and other biases including reverse causality and ecological fallacy. The second part of the book covers environmental epidemiological methods in detail and outlines key examples such as childhood leukemia and exposure to extremely low-frequency magnetic fields, as well as examples that look at brain tumors and mobile phone use. The book also offers a detailed discussion on the range of EMF sources and exposures. In addition, it highlights the sophisticated assessment methods required to address exposure situations, and provides a historical perspective. The third part of the book examines how EMF exposure from the use of wireless communication techniques and other challenges affect risk assessment today and also details future developments. Explores environmental epidemiological methods in detail, while critically discussing epidemiological findings Provides a state-of-the-art overview of the scientific evidence of the health effects of EMF Considers how novelty, the steep increase of radiofrequency (RF) EMF exposure from wireless communications, and other challenges affect risk assessment today Epidemiology of Electromagnetic Fields provides a thorough overview of the subject, and evaluates the scientific evidence surrounding the possible health effects of EMFs.

Rf Microwave Interaction With Biological Tissues

Author: André Vander Vorst
Publisher: John Wiley & Sons
ISBN: 0471752045
Size: 60.86 MB
Format: PDF
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From engineering fundamentals to cutting-edge clinical applications This book examines the biological effects of RF/microwaves and their medical applications. Readers will discover new developments in therapeutic applications in such areas as cardiology, urology, surgery, ophthalmology, and oncology. The authors also present developing applications in such areas as cancer detection and organ imaging. Focusing on frequency ranges from 100 kHz to 10 GHz, RF/Microwave Interaction with Biological Tissues is divided into six chapters: * Fundamentals in Electromagnetics--examines penetration of RF/microwaves into biological tissues; skin effect; relaxation effects in materials and the Cole-Cole model (display); the near field of an antenna; blackbody radiation and the various associated laws; and microwave measurements. * RF/Microwave Interaction Mechanisms in Biological Materials--includes a section devoted to the fundamentals of thermodynamics and a discussion on energy and entropy. * Biological Effects--investigates the effects of radio frequency fields on the nervous system, the brain and spinal cord, the blood-brain barrier, and cells and membranes. * Thermal Therapy--includes a description of applicators and an extensive discussion on the foundation of dielectric heating and inductive heating. * EM-Wave Absorbers Protecting the Biological and Medical Environment--investigates materials for EM-wave absorbers from both a theoretical and applications perspective. Special attention is given to ferrite absorbers. * RF/Microwave Delivery Systems for Therapeutic Applications--begins with the fundamental features of major components used in RF/microwave delivery systems for therapeutic applications. New research towards the development of future measurement techniques is also presented. The book features problem sets at the end of each chapter, making it an excellent introduction for bioengineering and engineering students. Researchers, physicians, and technicians in the field will also find this an excellent reference that offers all the fundamentals, the most cutting-edge applications, and insight into future developments. An Instructor's Manual presenting detailed solutions to all the problems in the book is available from the Wiley editorial department.

Limb Regeneration

Author: Panagiotis A. Tsonis
Publisher: Cambridge University Press
ISBN: 9780521441490
Size: 16.52 MB
Format: PDF
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This is the first book that analyses the mechanisms of limb regeneration by incorporating the information obtained from older experiments with the many new recent advances in molecular and cellular biology.

The Body Electric

Author: Robert Becker
Publisher: Harper Collins
ISBN: 0688069711
Size: 72.42 MB
Format: PDF
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The Body Electric tells the fascinating story of our bioelectric selves. Robert O. Becker, a pioneer in the filed of regeneration and its relationship to electrical currents in living things, challenges the established mechanistic understanding of the body. He found clues to the healing process in the long-discarded theory that electricity is vital to life. But as exciting as Becker's discoveries are, pointing to the day when human limbs, spinal cords, and organs may be regenerated after they have been damaged, equally fascinating is the story of Becker's struggle to do such original work. The Body Electric explores new pathways in our understanding of evolution, acupuncture, psychic phenomena, and healing.

Bioelectromagnetism

Author: Jaakko Malmivuo
Publisher: Oxford University Press, USA
ISBN: 9780195058239
Size: 49.26 MB
Format: PDF
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This book provides a general view of bioelectromagnetism and describes it as an independent discipline. It begins with an historical account of the many innovations and innovators on whose work the field rests. This is accompanied by a discussion of both the theories and experiments which were contributed to the development of the field. The physiological origin of bioelectric and biomagnetic signal is discussed in detail. The sensitivity in a given measurement situation, the energy distribution in stimulation with the same electrodes, and the measurement of impedance are related and described by the electrode lead field. It is shown that, based on the reciprocity theorem, these are identical and further, that these procedures apply equally well for biomagnetic considerations. The difference between corresponding bioelectric and biomagnetic methods is discussed. The book shows, that all subfields of bioelectromagnetism obey the same basic laws and they are closely tied together through the principle of reciprocity. Thus the book helps the reader to understand the properties of existing bioelectric and biomagnetic measurements and stimulation methods and to design new systems. The book includes about 300 carefully drawn illustrations and 500 references. It can be used as a textbook for third or fourth year university students and as a source of reference.