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The Statistical Evaluation Of Medical Tests For Classification And Prediction

Author: Margaret Sullivan Pepe
Publisher: Oxford University Press, USA
ISBN: 0198509847
Size: 54.83 MB
Format: PDF
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This book describes statistical techniques for the design and evaluation of research studies on medical diagnostic tests, screening tests, biomarkers and new technologies for classification and prediction in medicine. Based on solid mathematical theory, the book includes worked examples along with data and code, which provides the reader with easy implementation of methods.

Automated Image Detection Of Retinal Pathology

Author: Herbert Jelinek
Publisher: CRC Press
ISBN: 1420037005
Size: 56.63 MB
Format: PDF, Mobi
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Discusses the Effect of Automated Assessment Programs on Health Care Provision Diabetes is approaching pandemic numbers, and as an associated complication, diabetic retinopathy is also on the rise. Much about the computer-based diagnosis of this intricate illness has been discovered and proven effective in research labs. But, unfortunately, many of these advances have subsequently failed during transition from the lab to the clinic. So what is the best way to diagnose and treat retinopathy? Automated Image Detection of Retinal Pathology discusses the epidemiology of the disease, proper screening protocols, algorithm development, image processing, and feature analysis applied to the retina. Conveys the Need for Widely Implemented Risk-Reduction Programs Offering an array of informative examples, this book analyzes the use of automated computer techniques, such as pattern recognition, in analyzing retinal images and detecting diabetic retinopathy and its progression as well as other retinal-based diseases. It also addresses the benefits and challenges of automated health care in the field of ophthalmology. The book then details the increasing practice of telemedicine screening and other advanced applications including arteriolar-venous ratio, which has been shown to be an early indicator of cardiovascular, diabetes, and cerebrovascular risk. Although tremendous advances have been made in this complex field, there are still many questions that remain unanswered. This book is a valuable resource for researchers looking to take retinal pathology to that next level of discovery as well as for clinicians and primary health care professionals that aim to utilize automated diagnostics as part of their health care program.

Statistical Applications From Clinical Trials And Personalized Medicine To Finance And Business Analytics

Author: Jianchang Lin
Publisher: Springer
ISBN: 3319425684
Size: 30.98 MB
Format: PDF, Mobi
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The papers in this volume represent a broad, applied swath of advanced contributions to the 2015 ICSA/Graybill Applied Statistics Symposium of the International Chinese Statistical Association, held at Colorado State University in Fort Collins. The contributions cover topics that range from statistical applications in business and finance to applications in clinical trials and biomarker analysis. Each papers was peer-reviewed by at least two referees and also by an editor. The conference was attended by over 400 participants from academia, industry, and government agencies around the world, including from North America, Asia, and Europe.

Time Series Analysis By State Space Methods

Author: James Durbin
Publisher: OUP Oxford
ISBN: 0191627194
Size: 64.26 MB
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This new edition updates Durbin & Koopman's important text on the state space approach to time series analysis. The distinguishing feature of state space time series models is that observations are regarded as made up of distinct components such as trend, seasonal, regression elements and disturbance terms, each of which is modelled separately. The techniques that emerge from this approach are very flexible and are capable of handling a much wider range of problems than the main analytical system currently in use for time series analysis, the Box-Jenkins ARIMA system. Additions to this second edition include the filtering of nonlinear and non-Gaussian series. Part I of the book obtains the mean and variance of the state, of a variable intended to measure the effect of an interaction and of regression coefficients, in terms of the observations. Part II extends the treatment to nonlinear and non-normal models. For these, analytical solutions are not available so methods are based on simulation.

Handbook For Clinical Trials Of Imaging And Image Guided Interventions

Author: Nancy A. Obuchowski
Publisher: John Wiley & Sons
ISBN: 1118849736
Size: 65.46 MB
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Handbook for Clinical Trials of Imaging and Image-Guided Interventions is the first single-source, multi-disciplinary reference, based on the didactic sessions presented at the annual ‘Clinical Trials Methodology Workshop’ for radiologists, radiation oncologists and imaging scientists (sponsored by the Radiological Society of North America (RSNA)). It focuses on educating radiologists, radiation oncologists and those involved in imaging research with how to design and conduct clinical trials to evaluate imaging technology and imaging biomarkers. The internationally renowned contributors take a broad approach, starting with principles of technology assessment, and then move into specific topics covering the clinical trials of therapy and clinical research in imaging guided interventions including radiotherapy. They discuss the use of imaging as a predictor of therapeutic response, screening trial design, and the practicalities of how to run an efficient clinical trial and good working practices. Later chapters provide a comprehensive array of quantitative methods including: an introduction to statistical considerations in study design, biostatistical analysis methods and their role in clinical imaging research, methods for quantitative imaging biomarker studies, and an introduction to cost effectiveness analysis. Handbook for Clinical Trials of Imaging and Image-Guided Interventions will educate and prepare radiologists at all levels and in all capacities in planning and conducting clinical imaging trials.

Procrustes Problems

Author: John C Gower
Publisher: Oxford University Press on Demand
ISBN: 0198510586
Size: 55.82 MB
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Procrustean methods are used to transform one set of data to represent another set of data as closely as possible. This text is a systematic overview of Procrustean methods, presenting a unifying Analysis of Variance framework for different matching methods and the development of statistical tests.

Medizinische Statistik

Author: Hans J. Trampisch
Publisher: Springer-Verlag
ISBN: 364256996X
Size: 72.93 MB
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"Statistiken sind merkwürdige Dinge ...", dies wird so mancher Mediziner denken, wenn er sich mit der Biometrie befaßt. Sei es im Rahmen seiner Ausbildung oder im Zuge wissenschaftlicher oder klinischer Studien, Kenntnisse der Statistik und Mathematik sind unentbehrlich für die tägliche Arbeit des Mediziners. Ziel dieses Lehrbuches ist es, den Mediziner systematisch an biometrische Terminologie und Arbeitsmethoden heranzuführen, um ihn schließlich mit den Grundlagen der Wahrscheinlichkeitsrechung vertraut zu machen. Nach der Lektüre dieses Buches hält der Leser ein Werkzeug in den Händen, das ihm bei der Lösung medizinscher Fragestellungen hilft ebenso wie bei der Beschreibung von Ergebnissen wissenschaftlicher Studien und natürlich bei der Doktorarbeit!