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Biochemistry Of Human Cancer

Author: Oscar Bodansky
Publisher: Elsevier
ISBN: 0323143636
Size: 51.38 MB
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Biochemistry of Human Cancer focuses on advances in the application of biochemistry to the study of human cancers, such as neoplastic immunoglobulinopathies, cancer of the bladder, tumors of the neural crest, leukemias and lymphomas, and neoplasms of the bone. It also examines certain features of human cancer ranging from general metabolic characteristics to enzymic aspects and immunochemical considerations. Organized into 18 chapters, this book begins with an overview of the general metabolic features of cancer, with emphasis on the metabolism of lipids, proteins, and carbohydrates. It then discusses the important biochemical aspects of pulmonary and prostatic neoplasms, including the serum acid and alkaline phosphatase activities of prostatic carcinoma. The remaining chapters look at the role of enzymes and immunoglobulins in cancer, the tryptophan metabolism in cancer of the bladder and the carcinoid syndrome, the link between amino acid metabolism and tumors of the neural crest, and the neoplasms of the digestive tract and the accessory organs (pancreas and liver). The book explains the metabolism of purines and pyrimidines in cancer, hypercalcemia in neoplastic disease without evidence of bone metastases, and neoplasms of other organs, such as the pituitary gland, thyroid, testis, and adrenal cortex. Brief case reports from the literature are included to illustrate correlations between biochemical and clinical findings. Scientists, biochemists, and clinical investigators concerned with the biochemistry of human cancer will find this book highly informative.

Biochemistry Of Human Cancer

Author: Oscar Bodansky
Publisher: Elsevier
ISBN: 0323143636
Size: 76.79 MB
Format: PDF, ePub
View: 5944
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Biochemistry of Human Cancer focuses on advances in the application of biochemistry to the study of human cancers, such as neoplastic immunoglobulinopathies, cancer of the bladder, tumors of the neural crest, leukemias and lymphomas, and neoplasms of the bone. It also examines certain features of human cancer ranging from general metabolic characteristics to enzymic aspects and immunochemical considerations. Organized into 18 chapters, this book begins with an overview of the general metabolic features of cancer, with emphasis on the metabolism of lipids, proteins, and carbohydrates. It then discusses the important biochemical aspects of pulmonary and prostatic neoplasms, including the serum acid and alkaline phosphatase activities of prostatic carcinoma. The remaining chapters look at the role of enzymes and immunoglobulins in cancer, the tryptophan metabolism in cancer of the bladder and the carcinoid syndrome, the link between amino acid metabolism and tumors of the neural crest, and the neoplasms of the digestive tract and the accessory organs (pancreas and liver). The book explains the metabolism of purines and pyrimidines in cancer, hypercalcemia in neoplastic disease without evidence of bone metastases, and neoplasms of other organs, such as the pituitary gland, thyroid, testis, and adrenal cortex. Brief case reports from the literature are included to illustrate correlations between biochemical and clinical findings. Scientists, biochemists, and clinical investigators concerned with the biochemistry of human cancer will find this book highly informative.

Biology Of Fertilization V2

Author: Charles Metz
Publisher: Elsevier
ISBN: 032314814X
Size: 64.24 MB
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Biology of Fertilization, Volume 2: Biology of the Sperm is the second in a three-volume series that brings together various lines of research about reproduction in general and fertilization in particular. It is devoted to spermatogenesis, sperm physiology, and the initial interactions of sperm with egg components. The book is organized into three parts. Part I on spermatogenesis and sperm physiology includes studies on the evolution of the sperm cell; regulatory mechanisms, sperm antigen differentiation, and maturation of sperm in the reproductive tracts in mammals; physicochemical mechanisms of the acrosome filament extrusion process; and enzymes associated with sperm cell function. Part II deals with chemotaxis in microorganisms: bacteria and slime molds. Part III on gamete recognition and binding includes studies on identifying, isolating, and characterizing specific sperm and egg surface components involved in sperm-egg interaction; fertilization in the alga Fucus; fertilization in insects; and the role of lysins in fertilization.

Sertoli Cell Biology

Author: Michael D. Griswold
Publisher: Academic Press
ISBN: 012417048X
Size: 27.75 MB
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Sertoli Cell Biology, Second Edition summarizes the progress since the last edition and emphasizes the new information available on Sertoli/germ cell interactions. This information is especially timely since the progress in the past few years has been exceptional and it relates to control of sperm production in vivo and in vitro. Fully revised Written by experts in the field Summarizes 10 years of research Contains clear explanations and summaries Provides a summary of references over the last 10 years

Advances In Physiology Biochemistry And Function

Author: A.D. Johnson
Publisher: Elsevier
ISBN: 0323143741
Size: 67.16 MB
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The Testis: Advances in Physiology, Biochemistry, and Function, Volume IV, provides an overview of the state of knowledge in the physiology, biochemistry, and function of the testis. This volume updates those areas of greatest research activity and introduces in a more complete manner those topics which have developed as subject areas in themselves. It includes a chapter on testicular steroidogenesis, which updates and expands the chapter appearing in Volume II. In addition, chapters on the role of FSH in the testis, the specialized (largely endocrine) functions of the Sertoli cells, and the entire account of the tubular hormone inhibin have all been extensions of material in the original chapter on testicular endocrinology. Similarly, separate chapters on blood flow in the testis, fluid secretion, and the blood-testis barrier all report data on subjects largely unsuspected when Volumes I-III were published. Neither the first three volumes nor is the present one intended primarily for the nonprofessional biologist or the popular reader. The coverage should be most useful and informative to professional biologists. It is anticipated that this volume will also be of interest to advanced students of animal biology as an authoritative, comprehensive, and convenient review of significant recent information concerning the testis.

The Testis

Author: A.D. Johnson
Publisher: Elsevier
ISBN: 0323148573
Size: 49.23 MB
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The Testis, Volume II: Biochemistry focuses on the study of the biochemistry of mammalian testis. Composed of contributions of authors, the book starts with the endocrinology of the testis. Topics covered include testicular estrogens and androgens; the effect of age on testicular steroidogenesis; and endocrine regulation of spermatogenesis. The compilation also presents a histochemical analysis of the localization of testicular enzymes. Covered are histochemistry; enzymes of the fetal and mature testis; and the factors affecting testicular enzymes. The text notes as well that blood flow, hormones, nutrition, age, and temperature can affect testicular lipids and that the testis has testicular proteins and nucleic acids. The selection also outlines the growth and development of mammalian testis, and then ends with the discussions on hormonal regulation; chemical constituents; and testicular development, structure, and spermatogenesis of invertebrate testes. The compilation will best serve the interest of readers interested in studying the structure and functions of the testis.

Cell And Molecular Biology Of The Testis

Author: Des Jardins
Publisher: New York : Oxford University Press
ISBN: 9780195062694
Size: 64.56 MB
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This book is a comprehensive, multi-authored work on the structure and function of the mammalian testis. The approach emphasizes gene expression, translation and production of specific gene products and the cellular and molecular regulation of these fundamental processes. Rather than provide a global survey of all aspects of male reproduction, this book stresses specific mechanisms that underscore the structure and function of the testis. It explains old and new concepts from a cellular and molecular perspective. This novel approach allows the authors to forge links between cell and molecular biology and well-established aspects of spermatogenesis and steroidogenesis. The result is a well-focused, comprehensive, and synthetic analysis of testicular biology.

The Molecular Biology Of Fertilization

Author: Heide Schatten
Publisher: Elsevier
ISBN: 0323152007
Size: 68.14 MB
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The Molecular Biology of Fertilization focuses on the different aspects of fertilization in several models, including insects, clams, sea urchins, ascidians, cows, pigs, sheep, rats, hamsters, and humans. This book examines the experimental approaches using methods of molecular biology, cell biology, biochemistry, biophysics, immunology, and enzymology. Comprised of three parts encompassing 15 chapters, this book starts by discussing the ability of egg factors to affect sperm motility and initiate the acrosome reaction by modifying ion movements across the sperm plasma membrane. This text then provides an overview of the different aspects of egg architecture, ranging from extracellular remodeling to nuclei organization, which is involved in embryogenesis and fertilization. Finally, the last part deals with oncogenes, gene expression, and nuclear determination during embryogenesis and at fertilization. This book will be a great value to molecular biologists, cell biologists, reproductive biologists, developmental biologists, biophysicists, biochemists, geneticists, researchers, scientists, and students.

Recent Advances In Steroid Biochemistry

Author: J. R. Pasqualini
Publisher: Elsevier
ISBN: 1483140148
Size: 31.80 MB
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Recent Advances in Steroid Biochemistry contains the proceedings of the Second International Symposium of the Journal of Steroid Biochemistry. Separating 38 papers as chapters, this book discusses the partial purification of steroid-receptor complexes; enzymatic techniques in steroid assay; mass fragmentography of steroid hormones; biological consequences of 18-hydroxylation; and steroidogenesis in adrenal cells. This text also explores the regulation of steroidogenesis in testis; androgen binding proteins in different testis compartments; nuclear acceptor sites for glucocorticoid receptors; estrogen receptors in the pancreas; and molecular mechanisms of steroid hormone action.

Temperature And Environmental Effects On The Testis

Author: Adrian W. Zorgniotti
Publisher: Springer Science & Business Media
ISBN: 1468459139
Size: 78.53 MB
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It must be considered that there is nothing more difficult to carry out, nor more doubtful of success, nor more dangerous to handle, than to initiate a new order of things. Machiavelli: The Prince (1513) These are the Proceedings of a Conference on Temperature and Environmental Factors and the Testis which took place at New York University School of Medicine, December 8th and 9th, 1989. There is good reason to believe that this was the first of its kind to address, exclusively, the implications of temperature for this highly thermosensitive organ and its precious genetic cargo. The organizers of the Conference hoped to stimulate interest in this area which, paradoxically, has a considerable literature but which has received scant attention and sometimes outright opposition from clinicians expert in male infertility. There have been studies of the relationship of temperature to reproduction starting in the mid-18th Century with observations of the relationship of water temperature to spawning of fish. There is also a vast literature on the deleterious effects of externally applied heat upon spermatogenesis but little study of the possibility that intrinsic heat may be an important etiologic factor in subfertile semen. Today, fertility research has largely ignored this in favor of research in areas which have not produced successes, in terms of live births, comparable to what can be obtained by varicocelectomy (when appropriate) or scrotal hypothermia: viz. 1. Concentration upon the endocrine aspects of testicular function and its relation to spermatogenesis.