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The Vascular Smooth Muscle Cell

Author:
Publisher: Elsevier
ISBN: 9780080543505
Size: 57.86 MB
Format: PDF, Kindle
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In the last several years, the development of reagents that recognize smooth muscle-specific proteins has enabled researchers to identify smooth muscle cells (SMC) in tissue undergoing both differentiation and repair. These developments have led to increased research on SMC. The latest volume in the Biology of the Extracellular Matrix Series takes a current and all-encompassing look at this growing area of research. Devoted entirely to the subject of SMC, the book covers a diversity of topics-from SMC architecture and contractility to differentiation and gene expression in development. It also examines the proliferation and replication of SMC and its role in pharmacology and vascular disease. A must for cell, developmental, and molecular biologists, this book also will appeal to cardiologists, pathologists, and biomedical researchers interested in smooth muscle cells. Presents a molecular, genetic, and developmental perspective of the vas smooth muscle cell Overview sections highlight key points of chapters, including the clinical relevance of the research and expectations for future study Appeals to both the basic biologist and to the biomedical researcher of vascular disease

Molecular Biology Of The Cell

Author: Bruce Alberts
Publisher: Garland Science
ISBN: 1317563743
Size: 57.26 MB
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As the amount of information in biology expands dramatically, it becomes increasingly important for textbooks to distill the vast amount of scientific knowledge into concise principles and enduring concepts.As with previous editions, Molecular Biology of the Cell, Sixth Edition accomplishes this goal with clear writing and beautiful illustrations. The Sixth Edition has been extensively revised and updated with the latest research in the field of cell biology, and it provides an exceptional framework for teaching and learning. The entire illustration program has been greatly enhanced.Protein structures better illustrate structure–function relationships, icons are simpler and more consistent within and between chapters, and micrographs have been refreshed and updated with newer, clearer, or better images. As a new feature, each chapter now contains intriguing openended questions highlighting “What We Don’t Know,” introducing students to challenging areas of future research. Updated end-of-chapter problems reflect new research discussed in the text, and these problems have been expanded to all chapters by adding questions on developmental biology, tissues and stem cells, pathogens, and the immune system.

Developmental Vascular Biology

Author:
Publisher: Elsevier
ISBN: 0080494358
Size: 53.72 MB
Format: PDF, ePub
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Current Topics in Developmental Biology provides a comprehensive survey of the major topics in the field of developmental biology. The volumes are valuable to researchers in animal and plant development, as well as to students and professionals who want an introduction to cellular and molecular mechanisms of development. The series has recently passed its 30-year mark, making it the longest-running forum for contemporary issues in developmental biology. This volume contains ten important contributions from leading minds in developmental biology. * Series Editor Gerald Schatten is one of the leading minds in reproductive and developmental science * Presents major contemporary issues and astonishing discoveries at the forefront of modern developmental biology, stem cells and cloning, and regenerative medicine * The longest-running forum for current issues in developmental biology with over 30 years of coverage

Encyclopedic Reference Of Vascular Biology Pathology

Author: Andreas Bikfalvi
Publisher: Springer
ISBN: 3642570631
Size: 38.19 MB
Format: PDF, Docs
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This reference provides a synthesis of the whole field of vascular biology, from the latest advances in the study of the structure and function of blood vessels to recent investigations of their interaction with blood cells, with non-cellular constituants of the blood, or with cells of the neighbouring tissue. The latest results from tumor angiogenesis to the latest advances in atherosclerosis research are discussed by leading experts in the field. Together with the CD-ROM this guarantees both researchers and clinicians quick and easy access to all relevant information.

The Lung

Author: Kent Pinkerton
Publisher: Elsevier
ISBN: 9780080481357
Size: 70.23 MB
Format: PDF, ePub, Docs
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This unique book provides a concise account, written by world authorities in their fields, of how the mammalian lung grows and matures before birth and how the lungs, and their ability to function well, can be affected by the environment and by genetic factors, both before and after birth. It provides an understanding of the basis of some major lung diseases affecting infants and children. The book also deals with how the lung changes with age, and how the process of lung aging can be affected by the environment. * Discusses the mechanisms that regulate the initial events of lung morphogenesis * Provides a better understanding of the cellular and biochemical events involved in alveolarization * Development of the pulmonary immune system and how the exposure to allergens during development may lead to diseases such as asthma

Mechanobiology Handbook

Author: Jiro Nagatomi
Publisher: CRC Press
ISBN: 1420091220
Size: 63.67 MB
Format: PDF, Mobi
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Mechanobiology—the study of the effects of mechanical environments on the biological processes of cells—has evolved from traditional biomechanics via the incorporation of strong elements of molecular and cell biology. Currently, a broad range of organ systems are being studied by surgeons, physicians, basic scientists, and engineers. These mechanobiologists aim to create new therapies and further biological understanding by quantifying the mechanical environment of cells and the molecular mechanisms of mechanically induced pathological conditions. To achieve these goals, investigators must be familiar with both the basic concepts of mechanics and the modern tools of cellular/molecular biology. Unfortunately, current literature contains numerous studies that misuse standard mechanical estimations and terminology, or fail to implement appropriate molecular analyses. Therefore, the Mechanobiology Handbook not only presents cutting-edge research findings across various fields and organ systems, but also provides the elementary chapters on mechanics and molecular analysis techniques to encourage cross-field understanding and appropriate planning. Aided by the continuous advancement of research tools in both mechanics and biology, more sophisticated experiments and analyses are possible—thus fueling the growth of the field of mechanobiology. Considering the complexity of the mechanics and the biology of the human body, most of the world of biomechanics remains to be studied. Since the field is still developing, the Mechanobiology Handbook does not force one unified theory, but brings out many different viewpoints and approaches to stimulate further research questions.

Extracellular Matrix And The Liver

Author: Isao Okazaki
Publisher: Academic Press
ISBN: 9780125252515
Size: 32.77 MB
Format: PDF, Mobi
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Extracellular Matrix of the Liver addresses the basic science of the extracellular matrix and discusses new strategies for the treatment of cirrhosis of the liver, with a primary focus on possible gene therapy approaches. The chapters are divided into six sections as follows: * Basic Science of Extracellular Matrix * Cells Responsible for Extracellular Matrix Production * Activation Mechanism of Hepatic Cells and Signal Transduction * Basic Science for Extracellular Matrix Metabolism including Enzymes and their Inhibitors * Matrix Mettaloproteinases and Tissue Inhibitors for Matrix Mettaloproteinases * New Strategies for the treatment of Liver Cirrhosis Key Features * Discusses the possibility of gene therapy for liver cirrhosis * Includes information on new aspects of hepatic stellate cells * Written by top experts in basic science and clinical hepatology

Extracellular Matrix And The Liver

Author: Isao Okazaki
Publisher: Academic Press
ISBN: 9780125252515
Size: 54.46 MB
Format: PDF
View: 2753
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Extracellular Matrix of the Liver addresses the basic science of the extracellular matrix and discusses new strategies for the treatment of cirrhosis of the liver, with a primary focus on possible gene therapy approaches. The chapters are divided into six sections as follows: * Basic Science of Extracellular Matrix * Cells Responsible for Extracellular Matrix Production * Activation Mechanism of Hepatic Cells and Signal Transduction * Basic Science for Extracellular Matrix Metabolism including Enzymes and their Inhibitors * Matrix Mettaloproteinases and Tissue Inhibitors for Matrix Mettaloproteinases * New Strategies for the treatment of Liver Cirrhosis Key Features * Discusses the possibility of gene therapy for liver cirrhosis * Includes information on new aspects of hepatic stellate cells * Written by top experts in basic science and clinical hepatology

Extracellular Matrix In Development

Author: Douglas W. DeSimone
Publisher: Springer Science & Business Media
ISBN: 3642359353
Size: 20.76 MB
Format: PDF
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Cells in the developing embryo depend on signals from the extracellular environment to help guide their differentiation. An important mediator in this process is the extracellular matrix – secreted macromolecules that interact to form large protein networks outside the cell. During development, the extracellular matrix serves to separate adjacent cell groups, participates in establishing morphogenic gradients, and, through its ability to interact directly will cell-surface receptors, provides developmental clocks and positional information. This volume discusses how the extracellular matrix influences fundamental developmental processes and how model systems can be used to elucidate ECM function. The topics addressed range from how ECM influences early development as well as repair processes in the adult that recapitulate developmental pathways.

Extracellular Matrix Assembly And Structure

Author: Peter D. Yurchenco
Publisher: Academic Press
ISBN: 1483289427
Size: 58.12 MB
Format: PDF, Mobi
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The complex and critical process of extracellular matrix (ECM) assembly is described in this book. Assembly may involve molecules interacting with molecules of the same matrix class, such as in collagen, or interactions between different ECM molecules, such as in basement membranes. The text shows how this is driven by structural information within the matrix monomer. This information will be of interest to cell, developmental, and molecular biologists, biochemists, biophysicists, and biomedical researchers involved in macromolecular assembly, biological macromolecules, and extracellular matrix. Addresses assembly of most of the known classes of extracellular matrix macromolecules Discusses higher order structures produced by ECM Gives important concepts in ECM and cell-matrix interactions, Protein structure and protein-protein interactions, Development and tissue remodeling