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Therapeutic Monoclonal Antibodies

Author: Zhiqiang An
Publisher: John Wiley & Sons
ISBN: 1118210263
Size: 70.23 MB
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70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies. First book to address the discovery and development of antibody therapeutics in their entirety. Most chapters contain experimental data to illustrate the principles described in them. Authors provide detailed methodologies that readers can take away with them and use in their own laboratories.

Handbook Of Therapeutic Antibodies

Author: Stefan Dübel
Publisher: John Wiley & Sons
ISBN: 3527329374
Size: 19.22 MB
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Still the most comprehensive reference source on the development, production and therapeutic application of antibodies, this second edition is thoroughly updated and now has 30% more content. Volume I covers selection and engineering strategies for new antibodies, while the second volume look at novel therapeutic concepts and antibodies in clinical trial phases, as well as their potential. Volume III features detailed and specific information about each antibody currently approved for therapeutic purposes, including the clinical data. Beyond providing current knowledge, the authors discuss emerging technologies, future developments, and intellectual property issues, such that this handbook meets the needs of academic researchers, decision makers in industry and healthcare professionals in the clinic.

Development Of Antibody Based Therapeutics

Author: Mohammad A. Tabrizi
Publisher: Springer Science & Business Media
ISBN: 1441959556
Size: 71.23 MB
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Translational strategies for development of antibody-based therapeutics should allow understanding of the relationship between the ‘unit dose’ and ‘unit effect’ with respect to both beneficial and deleterious effects from early stages of development. The flow of information from later to earlier stages of development should provide opportunities to facilitate selection of more effective novel and next-generation drug candidates. Selection and evaluation of relevant biomarkers in early preclinical development in "relevant" animal models should allow for identifying potential risks to humans and establishing safe First-In-Human (FIH) dosing strategies. Hence, integration of knowledge with respect to target antigen properties such as antigen distribution, expression profile, kinetic properties, target pharmacology, antigen isoforms and pharmacological redundancy in health and disease, as well as antibody design criteria, such as antibody isotype, affinity, PK/PD and safety is a critical necessity for the design of effective translational strategies. Additionally, these factors will further offer critical differentiating characteristics for next-generation antibodies, and novel technologies prove instrumental in generation of biosuperior antibody candidates for market entry. This book will examine many important considerations necessary for the design of effective translational strategies during the development of antibody-based therapeutics.

Protein Therapeutics 2 Volume Set

Author: Tristan Vaughan
Publisher: John Wiley & Sons
ISBN: 3527699147
Size: 48.55 MB
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In this practice-oriented two volume handbook, professionals from some of the largest biopharmaceutical companies and top academic researchers address the key concepts and challenges in the development of protein pharmaceuticals for medicinal chemists and drug developers of all trades. Following an introduction tracing the rapid development of the protein therapeutics market over the last decade, all currently used therapeutic protein scaffolds are surveyed, from human and non-human antibodies to antibody mimetics, bispecific antibodies and antibody-drug conjugates. This ready reference then goes on to review other key aspects such as pharmacokinetics, safety and immunogenicity, manufacture, formulation and delivery. The handbook then takes a look at current key clinical applications for protein therapeutics, from respiratory and inflammation to oncology and immune-oncology, infectious diseases and rescue therapy. Finally, several exciting prospects for the future of protein therapeutics are highlighted and discussed.

Erste Hilfe Bei Brustkrebs

Author: Florian Schütz
Publisher: Springer-Verlag
ISBN: 3662557037
Size: 49.67 MB
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Das vorliegende Buch der Reihe WissenKompakt Medizin richtet sich an alle Patientinnen und deren Familien, die mit der Diagnose „Brustkrebs“ konfrontiert werden. Vom Umgang mit dem ersten Schock der Diagnose über operative, konservative und ergänzende Behandlungsmethoden klären Experten der Universitätsfrauenklinik Heidelberg auf. Ebenso sind medizinische Grundlagen und sozialrechtliche Aspekte verständlich und nachvollziehbar erläutert. Das Wissen um die Erkrankung ist der wichtigste Schritt in der Behandlung dieser! Betroffenen Frauen und ihren Familien soll dieses Buch Mut machen, mit der Erkrankung umzugehen und sie als Ratgeber im Alltag begleiten.

Feuer Im Kopf

Author: Susannah Cahalan
Publisher: FinanzBuch Verlag
ISBN: 3864155029
Size: 52.20 MB
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Susannah Cahalan ist jung, attraktiv, frisch verliebt, eine aufstrebende Journalistin – und gerät über Nacht in den schlimmsten Albtraum ihres Lebens. Innerhalb kürzester Zeit erkrankt sie schwer, leidet an Wahnvorstellungen und wird binnen weniger Wochen zum Schwerstpflegefall in der Psychiatrie. Vollgepumpt mit Medikamenten wird sie ans Bett gefesselt und vegetiert vor sich hin – dem Tod näher als dem Leben. Doch ihre Familie gibt nicht auf bis endlich der renommierte Neurologe Souhel Najjar hinzugezogen wird. Er findet heraus, dass Susannah an einer erst vor kurzem entdeckten Autoimmunerkrankung leidet, in deren Verlauf der Körper das eigene Gehirn angreift und Symptome wie Schizophrenie, Autismus und Wahnvorstellungen erzeugt. Einmal richtig diagnostiziert, sorgen die geeigneten Medikamente rasch und dauerhaft für Genesung und Susannah gewinnt ihr Leben zurück. Ihre Schilderung des Leidensweges ist eine bewegende und aufregende Geschichte über Familie, Liebe, Hoffnung und darüber, wie sich ein perfektes Leben innerhalb kürzester Zeit in eine Katastrophe verwandeln kann. Ein fesselndes Buch, das man nicht aus der Hand legen kann, bis die letzte Seite verschlungen ist.

Knochenkrankheiten

Author: Claus-Peter Adler
Publisher: Springer-Verlag
ISBN: 3662121603
Size: 28.16 MB
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Dieses interdisziplinäre Nachschlagewerk bietet Ihnen das Fundament für Ihre exakte Diagnose und gezielte Therapie-Planung. o Sie erhalten einen praxisorientierten Überblick über alle modernen und etablierten Diagnostik-Verfahren. o Didaktisch übersichtlich stehen die jeweiligen radiologischen und pathologisch-anatomischen Strukturen dem Text gegenüber. o Kurzgefaßte Therapievorschläge ergänzen die diagnostischen Richtlinien. => Das aktuelle Nachschlagewerk für die multidisziplinäre Zusammenarbeit von Orthopäden, Radiologen, Rheumatologen und Pathologen. Schnell * präzise * praxisgerecht

Neurologic Complications Of Cancer Therapy

Author: Eudocia Quant Lee, MD, MPH
Publisher: Demos Medical Publishing
ISBN: 1617050199
Size: 21.25 MB
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Neurologic side effects of cancer therapy can inhibit treatment, can be dose-limiting and can diminish quality-of-life. Neurotoxicity related to cancer therapy is a common problem in oncology practice and in clinical neurology. Recognition of neurologic complications of anticancer therapy is necessary due to potential confusion with metastatic disease, paraneoplastic syndromes or comorbid neurologic disorders that do not require reduction or discontinuation of therapy. Neurologic Complications of Cancer Therapy provides comprehensive coverage of the recognition and management of neurologic symptoms related to cancer therapy. The book includes sections on systemic therapy discussed by both agent and adverse event. The section on adverse events is particularly valuable to clinicians, allowing them to consult by symptom in cases where multiple agents have been administered and the source of the complication is uncertain. The systemic therapy section includes coverage of immunologic agents, biologics, and targeted therapies. The book also features sections on the complications of radiation therapy, complications of surgery and high-dose chemotherapy, and stem cell transplantation. Neurologic Complications of Cancer Therapy Features: A widely recognized team of editors Systemic therapy covered by therapeutic agent and by adverse event, enabling a "problem-oriented" approach for the clinician Coverage of newer modalities including immunologic agents, biologics, and targeted therapies Complete sections on complications of radiation therapy, surgery, high-dose chemotherapy, and stem-call transplantion

Drug Delivery In Oncology

Author: Felix Kratz
Publisher: John Wiley & Sons
ISBN: 3527647759
Size: 25.36 MB
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In this first authoritative overview on modern cancer chemotherapy 121 international specialists have contributed their experience and recent data for what is likely to become the gold standard in the field. The authors summarize knowledge gained over the past decade, from basic concepts to successful applications in the clinic, covering active and passive targeting strategies as well as tissue-specific approaches. All current and future targeted delivery systems are discussed, from ligand-based to antibody-based polymer-based systems, right up to micro- and nanoparticulate systems. A special section covers the delivery of nucleic acid therapeutics, such as siRNA, miRNA and antisense nucleotides. In each case, a description of the basic technique is followed by a discussion of the latest preclinical and clinical developments in the field. By virtue of its clear and didactic structure, rich illustrative material and summary chapters, this handbook and ready reference enables the efficient transfer of knowledge between different disciplines, from basic research to the clinician and vice versa. It is equally well suited for professionals, researchers and students in medical oncology and cancer biology, and is also excellent for teaching medical students the foundations of 21st century cancer chemotherapy.