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Trace Amines And Neurological Disorders

Author: Tahira Farooqui
Publisher: Academic Press
ISBN: 0128036168
Size: 31.85 MB
Format: PDF, ePub, Mobi
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Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors explores trace amines which, under normal conditions, are present in the mammalian brain and peripheral nervous tissues at very low (nanomolar) concentrations. However, in a diverse array of human pathologies ranging from substance abuse, depression, attention deficit hyperactivity disorder, eating disorders, schizophrenia, and other neurological and neuropsychiatric diseases, the levels of trace amines are unusually high with an imbalance in their functions. Furthermore, the rapid turnover of trace amines is evidenced by their dramatic increases following treatment with monoamine oxidase inhibitors (MAOI) or deletion of the MAO genes. This suggests that the concentration of trace amines may be considerably higher at neuronal synapses than predicted by steady-state measures, implicating some pathophysiological role. Therefore, understanding molecular mechanisms and developing selective agonists and antagonists for trace amine-associated receptors (TAARs) has become a good approach for treating these diseases. Although the effects of trace amines at low physiological concentrations in mammalian species have been difficult to demonstrate, they may serve to maintain the neuronal activity of other monoamine neurotransmitters by possessing postsynaptic modulatory effects, particularly dopamine and serotonin, within defined physiological limits. Such an effect of trace amines makes them ideal candidates for the development of novel therapeutics for a wide range of human disorders. This book presents up-to-date, cutting-edge, and comprehensive information on the link between trace amines and neurological disorders. Focuses on recent findings on trace amines, providing insights into the functional significance, molecular mechanisms, and biological relevance of TAARS in neurological disorders Edited work with chapters authored by leaders in the field from around the globe, the broadest, most expert coverage available Provides cutting-edge research on trace amines-mediated signaling in vertebrate model systems

Neurochemical Aspects Of Alzheimer S Disease

Author: Akhlaq A. Farooqui
Publisher: Academic Press
ISBN: 0128099380
Size: 20.78 MB
Format: PDF
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Neurochemical Aspects of Alzheimer's Disease provides a comprehensive overview of molecular aspects of risk factors, pathogenesis, biomarkers, and therapeutic strategies. The book focuses on molecular mechanisms and signal transduction processes associated with the pathogenesis, biomarkers, and therapeutic strategies of AD. The comprehensive and cutting edge information in this monograph may not only help in early detection of AD, but also promote discovery of new drugs to treat this chronic disease. Chapters discuss involvement of neural membrane phospholipids, sphingolipids, and cholesterol-derived lipid mediators, abnormal APP processing, and nucleic acid damage, risk factors, biomarker, and therapeutic strategies of Alzheimer's disease. This book is written for neurologists, neuroscientists, neurochemists, neuropharmacologists, and clinicianswho are interested in molecular mechanisms associated with the pathogenesis of age-related neurological disorders. Provides a comprehensive overview of molecular aspects of risk factors, pathogenesis, biomarkers, and therapeutic strategies for Alzheimer's disease Written for researchers, clinicians, and advanced graduate students in neurology, neuroscience, neurochemistry, and neuropharmacology Acts as the first book to provide a comprehensive description of the signal transduction processes associated with pathogenesis of Alzheimer's disease

Ischemic And Traumatic Brain And Spinal Cord Injuries

Author: Akhlaq A. Farooqui
Publisher: Academic Press
ISBN: 0128135972
Size: 68.70 MB
Format: PDF, Docs
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Considerable progress has been made on the pathogenesis and therapeutic strategies of neurotraumatic diseases recent years. Ischemic and Traumatic Brain and Spinal Cord Injuries: Mechanisms and Potential Therapies presents readers with comprehensive and cutting edge information on molecular mechanisms, including signal transduction processes associated with neurodegeneration and neuroprotection in ischemic, spinal cord, severe and mild brain injuries. The book also covers the molecular mechanisms of drugs used for the treatment of neurotraumatic disease. Chapters are organized by molecular aspects and neuroprotective strategies by disease, including ischemic injury, spinal cord injury, traumatic brain injury, and chronic traumatic encephalopathy. The author aims to integrate and consolidate knowledge on neurotraumatic diseases and hopes that it will provide the basis of more dramatic advances and developments not only on molecular mechanisms, but also on causes and treatment of neurotraumatic diseases. Offers a clearly written and logically organized and comprehensive overview of molecular aspects of risk factors, pathogenesis, biomarkers, and therapeutic strategies for ischemic, spinal cord, severe and mild brain injuries Provides cutting edge research information on signal transduction processes associated with neurodegeneration and neuroprotection in ischemic, spinal cord, severe and mild brain injuries Chapters organized by molecular aspects and neuroprotective strategies by disease, including ischemic injury, spinal cord injury, traumatic brain injury, and chronic traumatic encephalopathy

Taste And Smell

Author: Dietmar Krautwurst
Publisher: Springer
ISBN: 3319489275
Size: 23.83 MB
Format: PDF
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Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

The Headaches

Author: Jes Olesen
Publisher: Lippincott Williams & Wilkins
ISBN: 0781754003
Size: 35.14 MB
Format: PDF
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Established worldwide as the one definitive, encyclopedic reference on headache, The Headaches is now in its thoroughly revised, updated Third Edition. The foremost international authorities examine the mechanisms of over 100 types of headache and provide evidence-based treatment recommendations, including extensive tables of controlled clinical trials. This edition presents the revised International Headache Society classification of headaches and explains how to use this new classification for accurate diagnosis. Many headache entities are discussed for the first time, such as chronic migraines; primary headache attributed to sexual activity; primary stabbing, cough, exertional, and thunderclap headaches; hypnic headaches; and new daily persistent headaches. A new section focuses on childhood headaches. Chapters that focus on headaches in elderly patients and patients with psychiatric or medical diseases are also included.

Adams And Victor S Principles Of Neurology Ninth Edition

Author: Allan H. Ropper
Publisher: McGraw Hill Professional
ISBN: 0071702814
Size: 25.24 MB
Format: PDF, Mobi
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The definitive guide to the full spectrum of neurology Adams and Victor's Principles of Neurology provides all the information you will need to confidently handle any neurologic problem, from disorders of motility, and derangements of intellect, behavior, and language, to the degenerative and neuromuscular diseases. Having this gold standard text on your reference shelf is like being able to consult with skilled clinicians on a daily basis. More than a compilation of facts, Adams and Victor's delivers expert insights not found in any other resource that help you understand every aspect of neurological disease. Written in a conversational style, the text offers practical, yet in-depth, coverage of both common and rare illnesses. Adams and Victor's Principles of Neurology also includes timely, complete, and accessible treatment and clinical management strategies. FEATURES Balanced presentation of evidence-based research coupled with the perspectives and experience of world-renowned expert neurologists Logical six-part organization reviews the clinical method, cardinal presentations, diseases of the central nervous system, diseases of the peripheral nervous system, and psychiatric disorders A-to-Z coverage of cardinal manifestations, including disorders of the special senses; epilepsy and disorders of consciousness; disorders of energy, mood, autonomic, and endocrine functions; and neuromuscular, spinal cord, and psychiatric disease Focus on symptoms, etiology, diagnosis, and treatment offers complete, practical guidance in clinical practice Special section on growth, development, and aging related to neurologic disease presents the latest, cutting-edge research in this integral area

Schizoaffektive Psychosen

Author: Andreas Marneros
Publisher: Springer-Verlag
ISBN: 3642838138
Size: 28.26 MB
Format: PDF, Mobi
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Die steigende Zahl von Publikationen und internationalen Kongressen über die schizoaffektiven Psychosen waren Anlaß, dieses Thema erstmalig ausführlich und umfassend in Buchform darzustellen. Namhafte Wissenschaftler aus dem In- und Ausland vermitteln praktische, klinisch relevante Informationen über die Diagnose, den Verlauf, die Therapie und die Prophylaxe der schizoaffektiven Psychosen. Angesprochen werden auch genetische und soziale Aspekte sowie Zukunftsperspektiven.