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Translational Research And Discovery In Gastroenterology

Author: Deborah L. Gumucio
Publisher: John Wiley & Sons
ISBN: 1118492854
Size: 55.73 MB
Format: PDF
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Translational Gastroenterology: Organogenesis to Disease bridges the gap between basic and clinical research by providing information on GI (gastrointestinal) organ development discovered through scientific inquiry, alongside clinical observations of acquired and congenital abnormalities. Paired chapters, written from basic science and clinical viewpoints, review the major biological pathways and molecules at work in organ ontogeny and disease. In addition to a comprehensive survey of GI organ development and pathologies, the book also highlights model organisms and new areas of research, with chapters devoted to recent advances in the field of GI stem cell biology, and the potential for tissue engineering of GI organs. The topics covered provide a unique window onto current activity in the field of gastroenterology, fostering enhanced knowledge for developmental biologists as well as for clinical practitioners. Notable features include the following: • Basic science chapters review the molecular and cellular pathways of GI organ development alongside clinical chapters examining organ-based diseases, closing the gap between the bench and the clinic. • Derivative organs – esophagus, stomach, pylorus, small intestine, colon, liver, and pancreas –as well as tissues such as serosa and enteric nervous system that are common to multiple GI organs. • Chapters detailing the use of model organisms – Drosophila, sea urchin, zebrafish, C. elegans, Xenopus – for basic discovery studies are included. • Chapters on GI stem cells and the potential for tissue engineering of the GI organs provide a view to the future of research and therapy in these organs.

Embriologia Cl Nica

Author: Keith Moore
Publisher: Elsevier Brasil
ISBN: 8535285032
Size: 47.24 MB
Format: PDF, ePub
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Compreenda e atualize seus estudos de embriologia humana com este livro didático orientado para a clínica, que aborda este assunto tão complexo de forma mais detalhada e visualmente sofisticada. Escrito por anatomistas mundialmente reconhecidos, apresenta vistas, de cada semana e fase, dos sistemas e órgãos fetais em desenvolvimento, explica porque e quando as malformações congênitas ocorrem e as funções da placenta e membranas fetais no desenvolvimento.• Entenda todos os mais recentes avanços na embriologia, incluindo os estudos da embriogênese normal e anormal, das causas das malformações congênitas e do papel dos genes no desenvolvimento humano.• Veja como as descobertas na biologia molecular, incluindo as novas técnicas sofisticadas de DNA recombinante e a manipulação de células-tronco, têm influenciado a prática clínica.• Prepare-se para exames de licenciamento com as apresentações de casos clínicos, destacadas em quadros especiais, que demonstram como os conceitos de embriologia se relacionam com a prática clínica.• Acesse o conteúdo completo do livro on-line em studentconsult.com — assim como 16 incríveis animações que avivam o desenvolvimento embriológico normal e anormal, imagens para download e centenas de questões e respostas de revisão adicionais para testar o seu domínio da matéria.• Compreenda todos os detalhes da embriologia humana com o livro de conteúdo orientado para a clínica mais abrangente e ricamente ilustrado, escrito pelos principais especialistas do mundo.• Prepare-se eficientemente para exames com as questões e respostas de revisão ao final de cada capítulo.

Principles Of Tissue Engineering

Author: Robert Lanza
Publisher: Academic Press
ISBN: 0123983703
Size: 21.43 MB
Format: PDF, ePub, Docs
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Now in its fourth edition, Principles of Tissue Engineering has been the definite resource in the field of tissue engineering for more than a decade. The fourth edition provides an update on this rapidly progressing field, combining the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation by the world’s experts of what is currently known about each specific organ system. As in previous editions, this book creates a comprehensive work that strikes a balance among the diversity of subjects that are related to tissue engineering, including biology, chemistry, material science, and engineering, among others, while also emphasizing those research areas that are likely to be of clinical value in the future. This edition includes greatly expanded focus on stem cells, including induced pluripotent stem (iPS) cells, stem cell niches, and blood components from stem cells. This research has already produced applications in disease modeling, toxicity testing, drug development, and clinical therapies. This up-to-date coverage of stem cell biology and other emerging technologies –such as brain-machine interfaces for controlling bionics and neuroprostheses– is complemented by a series of new and updated chapters on recent clinical experience in applying tissue engineering, as well as a new section on the application of tissue-engineering techniques for food production. The result is a comprehensive textbook that will be useful to students and experts alike. Includes new chapters on biomaterial-protein interactions, nanocomposite and three-dimensional scaffolds, skin substitutes, spinal cord, vision enhancement, and heart valves Offers expanded coverage of adult and embryonic stem cells of the cardiovascular, hematopoietic, musculoskeletal, nervous, and other organ systems Full-color presentation throughout

Textbook Of Gastroenterology

Author: Tadataka Yamada
Publisher: John Wiley & Sons
ISBN: 144435941X
Size: 45.41 MB
Format: PDF, Mobi
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Over the past twenty years, thousands of physicians have come to depend on Yamada’s Textbook of Gastroenterology. Its encyclopaedic discussion of the basic science underlying gastrointestinal and liver diseases as well as the many diagnostic and therapeutic modalities available to the patients who suffer from them was—and still is—beyond compare. This new edition provides the latest information on current and projected uses of major technologies in the field and a new section on diseases of the liver. Plus, it comes with a fully searchable CD ROM of the entire content.

Translating Regenerative Medicine To The Clinic

Author: Jeffrey Laurence
Publisher: Academic Press
ISBN: 0128005521
Size: 42.81 MB
Format: PDF, Kindle
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Translating Regenerative Medicine to the Clinic reviews the current methodological tools and experimental approaches used by leading translational researchers, discussing the uses of regenerative medicine for different disease treatment areas, including cardiovascular disease, muscle regeneration, and regeneration of the bone and skin. Pedagogically, the book concentrates on the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field. It promotes cross-disciplinary communication between the sub-specialties of medicine, but remains unified in theme by emphasizing recent innovations, critical barriers to progress, the new tools that are being used to overcome them, and specific areas of research that require additional study to advance the field as a whole. Volumes in the series include Translating Gene Therapy to the Clinic, Translating Regenerative Medicine to the Clinic, Translating MicroRNAs to the Clinic, Translating Biomarkers to the Clinic, and Translating Epigenetics to the Clinic. Encompasses the latest innovations and tools being used to develop regenerative medicine in the lab and clinic Covers the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field Contains extensive pedagogical updates aiming to improve the education of translational researchers in this field Provides a transdisciplinary approach that supports cross-fertilization between different sub-specialties of medicine

Regenerative Medicine Applications In Organ Transplantation

Author: Giuseppe Orlando
Publisher: Academic Press
ISBN: 012398520X
Size: 19.47 MB
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Regenerative Medicine Applications in Organ Transplantation illustrates exactly how these two fields are coming together and can benefit one another. It discusses technologies being developed, methods being implemented, and which of these are the most promising. The text encompasses tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, all from a transplant perspective. Organ systems considered include liver, renal, intestinal, pancreatic, and more. Leaders from both fields have contributed chapters, clearly illustrating that regenerative medicine and solid organ transplantation speak the same language and that both aim for similar medical outcomes. The overall theme of the book is to provide insight into the synergy between organ transplantation and regenerative medicine. Recent groundbreaking achievements in regenerative medicine have received unprecedented coverage by the media, fueling interest and enthusiasm in transplant clinicians and researchers. Regenerative medicine is changing the premise of solid organ transplantation, requiring transplantation investigators to become familiar with regenerative medicine investigations that can be extremely relevant to their work. Similarly, regenerative medicine investigators need to be aware of the needs of the transplant field to bring these two fields together for greater results. Bridges the gap between regenerative medicine and solid organ transplantation and highlights reasons for collaboration Explains the importance and future potential of regenerative medicine to the transplant community Illustrates to regenerative medicine investigators the needs of the transplant discipline to drive and guide investigations in the most promising directions

Intercellular Signaling In Development And Disease

Author: Edward A. Dennis
Publisher: Academic Press
ISBN: 0123822165
Size: 62.43 MB
Format: PDF, Kindle
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Required reading for anyone involved in cell signaling research with articles written and edited by experts in the field. This title covers disease states such as lymphoid leukemia, breast cancer, pulmonary fibrosis, systemic sclerosis, andinflammatory bowel disease, along with up-to-date research on signaling systems and mutations in transcription factors that provide new targets for treating disease. Articles written and edited by experts in the field Thematic volume covering disease states such as lymphoid leukemia, breast cancer, pulmonary fibrosis, systemic sclerosis, and inflammatory bowel disease Up-to-date research on signaling systems and mutations in transcription factors that provide new targets for treating disease

Micrornas

Author: Krishnarao Appasani
Publisher: Cambridge University Press
ISBN: 0521865980
Size: 68.44 MB
Format: PDF, Docs
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This wide-ranging reference work will be an invaluable resource for all those wishing to use miRNA techniques in their own research, both in academia and industry. From their discovery, functions and detection to their role in disease biology, this volume uniquely integrates basic miRNA biology with future applications.

Innovative Medicine

Author: Kazuwa Nakao
Publisher: Springer
ISBN: 4431556516
Size: 49.96 MB
Format: PDF
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This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.