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Trp Channels In Sensory Transduction

Author: Rodolfo Madrid
Publisher: Springer
ISBN: 3319187058
Size: 33.89 MB
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TRP channels play a key role in sensory physiology and have been the focus of intensive investigation in recent years. The proposed book will be a comprehensive, detailed overview of the ways in which TRP channels are involved in a wide variety of sensory modalities. Authors will explore the involvement of TRP channels in photo transduction (sight), chemotransduction (taste and odor), mechanotransduction (touch and hearing), thermo transduction (the sensation of temperature) and pain perception. Furthermore, the book will include some grounding chapters such as one on the history of TRP channel research, one on the biophysical characteristics of the proteins and one on trafficking and post-translational regulation.

Trp Ion Channel Function In Sensory Transduction And Cellular Signaling Cascades

Author: Wolfgang B. Liedtke, MD, PH.D.
Publisher: CRC Press
ISBN: 1420005847
Size: 22.92 MB
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Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of stimuli from both within and outside the cell body. How we sense heat and cold, how we taste food, how eggs are fertilized, how the heart expands and contracts is each dependent on the function of these channels. While no single book could possibly cover all the research being undertaken, TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades presents the most advanced compilation of work in this area to date. All 31 chapters are written by international pioneers working at the vanguard of TRP ion channel research. They explain much about the pivotal function and behavior of these channels, which are most exquisitely tuned to their specific tasks, and delve into how researchers are putting this knowledge to use in the development of novel pharmaceuticals, which may well prove effective in ameliorating treatment-resistant conditions including cancer, heart disease, inflammation, and immune system dysfunctions. Individual chapters shed light on selected topics of interest in the TRP arena, such as signal transduction in axonal path-finding, and in vascular, renal, and auditory functions, as well as pain. The text also covers subjects as diverse as mating and fertilization, inflammatory pain, and mechanisms of pheromone detection in mammals. While the book presents much new insight and explores findings that will be of interest to those involved with advanced research, it also includes significant background material for those looking to familiarize themselves with this exceptionally promising path of inquiry.

Transduction Channels In Sensory Cells

Author: Stephan Frings
Publisher: John Wiley & Sons
ISBN: 3527604979
Size: 26.18 MB
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This is the first book to provide a molecular level explanation of how the senses work, linking molecular biology with sensory physiology to deduce the molecular mechanism of a key step in sensory signal generation. The editors have assembled expert authors from all fields of sensory physiology for an authoritative overview of the mechanisms of sensory signal transduction in both animals and plants. They systematically cover phototransduction, chemosensory transduction, mechanotransduction, temperature and pain perception, as well as specialized receptors for electrical and magnetic signals. Required reading for biologists, physiologists and medical researchers with an interest in sensory physiology.

Trp Channels

Author: Michael X. Zhu
Publisher: CRC Press
ISBN: 1439818614
Size: 72.81 MB
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The rapid expansion of the TRP field has generated a large amount of excellent original work across many different research fields. However, investigators are not necessarily familiar with the pros and cons of the variety of methods used to study TRP channels. Because of functional and genetic diversity, as well as the different physiological roles they play, techniques used for studying TRP channels range from single molecular analysis to behavioral animal studies. Methods in multiple areas, such as molecular biology, fluorescence imaging, electrophysiology, cell biology, genetics, proteomics, pharmacology, system physiology, and behavioral assessment, are employed to investigate various aspects of these channels. Choosing among many possible topics in these broad areas was a daunting task. A comprehensive review of the field, TRP Channels spans the information gap by providing broad coverage of current methods and techniques commonly used in TRP channel research, and detailed protocols with thorough discussions of the advantages and disadvantages across methods. Some topics covered include Mammalian, Drosophila and C. elegans TRP channels Practical protocols for functional studies of TRP channels, including TRPC, TRPV, TRPA, TRPM and the intracellularly localized TRPML channels ThermoTRPs, including the new fast temperature jump apparatus and the high throughput random mutagenesis method for screening critical motifs involved in TRP channel regulation Cell-based high-throughput screening assays for TRP channels and their applications in drug discoveries TRP channel functions in native cells, including smooth muscles, neurons, and cancers Showcasing the current status of the field, TRP Channels covers the major techniques used in various areas of research. The majority of the chapters are protocol oriented, with the goal of providing clear directions for laboratory use. Because of the breadth of the TRP field, the applications of some methods are described in multiple chapters by experts working on a variety of channel types that serve different physiological functions, highlighting distinctive views on how the methodology can be utilized. Some chapters include discussion on the usefulness and pitfalls associated with the use of certain techniques. Together with chapters that offer comprehensive reviews on the functional regulation and other roles of TRP channels, students and investigators new to the field should find this book particularly informative.

The Nociceptive Membrane

Publisher: Elsevier
ISBN: 9780080463629
Size: 28.67 MB
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Membranes are essential cellular organelles. They not only define cells and other organelles, but also are critical in the cell function by selectively regulating the passage of molecules by acting as a matrix for other signaling molecules, and as conduits of information transfer between the external environment and the cell interior. This series was originally added in 1970 and has since provided a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology. This series has been a mainstay for practicing scientists and students interested in this critical field of biology. Articles covered in the volume include History of Ion Channels in the Pain Sensory System; Historical Overview; TRPV1, a Polymodal Sensor in the Nociceptor Terminal; Nociceptive Signals to TRPV1 and its Clinical Potential; Gating, Sensitization and Desensitization of TRPV1; TRP Channels as Thermosensors; ASIC Channels; P2X Receptors in Sensory Neurons; Voltage-Gated Sodium Channels and Neuropathic Pain; Voltage-Gated Potassium Channels in Sensory Neurons.

Mammalian Trp Channels As Molecular Targets

Author: Derek J. Chadwick
Publisher: John Wiley & Sons
ISBN: 0470862572
Size: 47.74 MB
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This book brings together contributions from key investigators in the area of Transient Receptor Potential (TRP) channel structure and function. It covers the structure, function and regulation of mammalian TRP channels and mechanisms of signal transduction. The discussions indicate research that would improve understanding of the role of TRP channels in normal cellular physiology, the involvement of TRP channels in disease states and their potential use as molecular targets for novel therapeutic agents.

Issues In Otorholaryngology Audiology And Speech Pathology Research And Practice 2011 Edition

Publisher: ScholarlyEditions
ISBN: 1464964726
Size: 13.58 MB
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Issues in Otorholaryngology, Audiology, and Speech Pathology Research and Practice: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Otorholaryngology, Audiology, and Speech Pathology Research and Practice. The editors have built Issues in Otorholaryngology, Audiology, and Speech Pathology Research and Practice: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Otorholaryngology, Audiology, and Speech Pathology Research and Practice in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Otorholaryngology, Audiology, and Speech Pathology Research and Practice: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at

Sensing With Ion Channels

Author: Boris Martinac
Publisher: Springer Science & Business Media
ISBN: 3540726837
Size: 19.90 MB
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This is the first book that is not exclusively focused on ion channels functioning in sensory mechanisms that are characteristic of animals and humans, but also describes the role of ion channels in signal transduction mechanisms found in microbial cells and plants. It summarizes comprehensively the progress that has been made in studies of ion channels and their role in sensory physiology.

Mechanosensitive Ion Channels

Author: Andre Kamkin
Publisher: Springer Science & Business Media
ISBN: 1402064268
Size: 65.40 MB
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This book explores the latest data dealing with mechanosensitive channels research results. It was compiled by a group of internationally recognized scientists leading in the field of mechanosensitive ion channels or mechanically gated channels and signaling cascades research. Key problems of cell mechanobiology are also discussed. As a whole, the volume dwells on the major issues of mechanical stress influencing the ion channels and intracellular signaling pathways.

Molecular Mechanisms Of Touch Sensory Transduction In C Elegans

Author: Wei-Hsiang Lee
Size: 48.48 MB
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Mechanical signaling plays an important role in cell shape and volume regulation, touch sensation, hearing, proprioception, gravitaxis, and turgor regulation. C. elegans provides a powerful model for elaborating mechanisms of eukaryotic mechanotransduction. Genetic screening identified candidate touch-transducing channels (DEG/ENaCs and TRP channels). In C. elegans, six touch neurons (ALML/R, AVM, PLML/R, PVM) are located in specific places in the body, optimized to detect forces delivered to those parts of the body. MEC-4 is expressed in six touch sensory neurons. MEC-10, on the other hand, is expressed in these six neurons, as well as in two extra pairs of neurons, PVDL/R and FLPL/R. Laser ablation studies showed that the six touch neurons respond to gentle and harsh body touch and suggested that FLP and PVD neurons are responsible for the harsh touch response. MEC-10 encodes a component of the core gentle touch sensory channel that is expressed in both gentle touch and harsh touch neurons. I studied the first mec-10 null mutant and showed that MEC-10 is required for both gentle and harsh touch sensation in C. elegans since the mec-10 null mutant is gentle touch insensitive and reduces harsh touch responses. We also used the intracellular calcium reporter cameleon to show that responses of gentle touch neurons and PVD/FLP to touch stimuli decreased in mec-10 null mutant. However, mec-10 null mutation has no significant impact on proprioception and mec-10(d)-induced neurodegeneration. I also made mec-4 and mec-10 hybrid proteins by switching their extracellular and transmembrane domains and checked their function by rescuing assay. Failure to complement the touch sensation function suggested that specific sequences are required for the normal functions of mec-4 and mec-10; smaller perturbation may be needed to recover protein function in chimeras. Based on the solved MEC-4 N-terminal NMR structure prediction, I introduced point mutations into this domain and studied biological consequences in genetic rescue assays and by monitoring dominant negative effects normally seen when the N-terminal is expressed alone. I found that generally, the amino acid substitutions predicted to perturb structure disrupt channel function as predicted. The disrupted mutant strains can also exhibit a significantly decreased density of immuno-stained channel puncta distributed along touch neuron processes. However, the rescue of channel function and the dominant negative effects are not well correlated. Overall, my data advance understanding of MEC-10 and MEC-4 function on mechanosensation.