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Virus As Populations

Author: Esteban Domingo
Publisher: Academic Press
ISBN: 0128009942
Size: 71.37 MB
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Virus as Populations: Composition, Complexity, Dynamics, and Biological Implications explains fundamental concepts that arise from regarding viruses as complex populations when replicating in infected hosts. Fundamental phenomena in virus behavior, such as adaptation to changing environments, capacity to produce disease, probability to be transmitted or response to treatment, depend on virus population numbers and in the variations of such population numbers. Concepts such as quasispecies dynamics, mutations rates, viral fitness, the effect of bottleneck events, population numbers in virus transmission and disease emergence, new antiviral strategies such as lethal mutagenesis, and extensions of population heterogeneity to nonviral systems are included. These main concepts of the book are framed in recent observations on general virus diversity derived from metagenomic studies, and current views on the origin of viruses and the role of viruses in the evolution of the biosphere. Features current views on the key steps in the origin of life and origins of viruses Includes examples relating ancestral features of viruses with their current adaptive capacity Explains complex phenomena in an organized and coherent fashion that is easy to comprehend and enjoyable to read Considers quasispecies as a framework to understand virus adaptability and disease processes

Foot And Mouth Disease Virus

Author: Francisco Sobrino
Publisher: Caister Academic Press
ISBN: 1910190527
Size: 62.73 MB
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Fifteen years after the devastating 2001 European foot-and-mouth disease (FMD) outbreak, the virus causing that shocking episode continues to pose a major threat to animal health worldwide. The development of more effective, sustainable and socially acceptable disease control measures remains a key task. This volume provides essential scientific background on FMD and its etiological agent, FMD virus, as well as comprehensive, interdisciplinary and up-to-date information on basic research findings and applied developments contributing to FMD control. The eighteen chapters have been written by leading FMD researchers. Topics include genome organization, translation and replication, virus-coded proteinases, structure of virus particles, cell receptors and host range, the RNA polymerase, quasispecies dynamics and virus evolution, innate and acquired immune responses, and the clinical signs of FMD and its natural habitats. Further chapters deal with various aspects of disease control such as diagnosis, current and new vaccines, antivirals and models of epidemiology. The role of international organizations in FMD control and the impact of FMDV as a re-emergent virus are also addressed. The book is required reading for everyone involved in FMD and is an important acquisition for all microbiology libraries.

Quasispecies Concept And Implications For Virology

Author: Esteban Domingo
Publisher: Springer Science & Business Media
ISBN: 3540263977
Size: 14.48 MB
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Continuous genetic variation and selection of virus subpopulations in the course of RNA virus replications are intimately related to viral disease mechanisms. The central topics of this volume are the origins of the quasispecies concept, and the implications of quasispecies dynamics for viral populations.

Progress In Drug Research

Author: Hao Wu
Publisher: Springer Science & Business Media
ISBN: 9783764369873
Size: 28.15 MB
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Progress in Drug Research is a prestigious book series which provides extensive expert-written reviews on a wide spectrum of highly topical areas in current pharmaceutical and pharmacological research. It serves as an important source of information for researchers concerned with drug research and all those who need to keep abreast of the many recent developments in the quest for new and better medicines.

Parasitoid Community Ecology

Author: Bradford A. Hawkins
Publisher: Oxford University Press on Demand
Size: 26.89 MB
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The study of parasitoid communities has direct relevance to general ecological theory and to the applied practice of biological control. Yet, despite the existence of a large and active international research community involved in the study of parasitoids, until now no books devoted to the theme of parasitoid community ecology have been available. Here, with a healthy mix of general discussions and specific examples such as tortricids and weevils, the authors constructively review and evaluate our understanding of these often very complex systems. The book emphasizes basic science, linking the discussion to wider areas such as population dynamics, food webs, competition, and community structure. The more applied end of the subject is covered in a section exclusively devoted to biological control. This book, the first to deal entirely with ecological aspects of parasitoid biology, offers summaries of the state of the field by leading researchers and identifies critical areas in need of further investigation. Students, researchers, and teachers in the field of ecology, animal behavior, entomology, forestry, and agriculture will all want to have a copy of the book on their shelves.