Download weighted network analysis applications in genomics and systems biology in pdf or read weighted network analysis applications in genomics and systems biology in pdf online books in PDF, EPUB and Mobi Format. Click Download or Read Online button to get weighted network analysis applications in genomics and systems biology in pdf book now. This site is like a library, Use search box in the widget to get ebook that you want.



Weighted Network Analysis

Author: Steve Horvath
Publisher: Springer Science & Business Media
ISBN: 9781441988195
Size: 72.76 MB
Format: PDF
View: 7761
Download and Read
High-throughput measurements of gene expression and genetic marker data facilitate systems biologic and systems genetic data analysis strategies. Gene co-expression networks have been used to study a variety of biological systems, bridging the gap from individual genes to biologically or clinically important emergent phenotypes.

Genomics Circuits And Pathways In Clinical Neuropsychiatry

Author: Thomas Lehner
Publisher: Academic Press
ISBN: 0128005300
Size: 40.35 MB
Format: PDF, Docs
View: 2353
Download and Read
This foundational work comprehensively examines the current state of the genetics, genomics and brain circuitry of psychiatric and neurological disorders. It consolidates discoveries of specific genes and genomic regions associated with these conditions, the genetic and anatomic architecture of these syndromes, and addresses how recent advances in genomics are leading to a reappraisal of the biology underlying clinical neuroscience. In doing so, it critically examines the promise and limitations of these discoveries toward treatment, and to the interdisciplinary nature of understanding brain and behavior. Coverage includes new discoveries regarding autism, epilepsy, intellectual disability, dementias, movement disorders, language impairment, disorders of attention, schizophrenia, and bipolar disorder. Genomics, Circuits, and Pathways in Clinical Neuropsychiatry focuses on key concepts, challenges, findings, and methods in genetics, genomics, molecular pathways, brain circuitry, and related neurobiology of neurologic and psychiatric disorders. Provides interdisciplinary appeal in psychiatry, neurology, neuroscience, and genetics Identifies key concepts, methods, and findings Includes coverage of multiple disorders from autism to schizophrenia Reviews specific genes associated with disorders Discusses the genetic architecture of these syndromes Explains how recent findings are influencing the understanding of biology Clarifies the promise of these findings for future treatment

Social Network Analysis Applied To Team Sports Analysis

Author: Filipe Manuel Clemente
Publisher: Springer
ISBN: 3319258559
Size: 59.51 MB
Format: PDF, ePub, Docs
View: 4223
Download and Read
Explaining how graph theory and social network analysis can be applied to team sports analysis, This book presents useful approaches, models and methods that can be used to characterise the overall properties of team networks and identify the prominence of each team player. Exploring the different possible network metrics that can be utilised in sports analysis, their possible applications and variances from situation to situation, the respective chapters present an array of illustrative case studies. Identifying the general concepts of social network analysis and network centrality metrics, readers are shown how to generate a methodological protocol for data collection. As such, the book provides a valuable resource for students of the sport sciences, sports engineering, applied computation and the social sciences.

Neuroepigenomics In Aging And Disease

Author: Raul Delgado-Morales
Publisher: Springer
ISBN: 3319538896
Size: 58.32 MB
Format: PDF, ePub, Docs
View: 4260
Download and Read
Epigenetic mechanisms (DNA modifications, histone alterations and non-coding RNAs) are crucial for transcriptional regulation and alterations of the “physiological epigenome” are increasingly associated with human diseases. During the last decade the emerging field of neuroepigenomics have started to impact tremendously in areas such learning and memory, addiction or neurodegeneration. This expert volume covers the role of epigenetic molecular mechanism in regulation of central nervous system’s function, one of the most exciting areas of contemporary molecular neuroscience. The book describes the current knowledge on the epigenetic basis of human disease covering the complete lifespan: from neurodevelopment/childhood (Rett Syndrome, Rubinstein-Taybi, autism), adolescence (eating disorders, drug addiction, anxiety), adulthood (depression, schizophrenia, amyotrophic lateral sclerosis, Huntington’s disease) and elderly (Alzheimer’s disease, Parkinson’s disease). The book also covers the three major players on neuroepigenomic mechanisms: histones alterations, DNA modifications and non-coding RNAs, their roles at the molecular and cellular level and the impact of their alterations on neuronal function and behavior. Finally, a special chapter on state-of-the-art technologies helps the reader not only to understand epigenetic driven changes in human cognition and diseases but also the methodology that will help to generate paradigm shifts on our understanding of brain function and the role of the neuroepigenome in human diseases.

The Omics

Author: Giovanni Coppola
Publisher: Oxford University Press
ISBN: 0199355002
Size: 49.33 MB
Format: PDF, Docs
View: 2603
Download and Read
The OMICs: Applications in Neuroscience summarizes the state of the art in high-throughput approaches (collectively known as 'OMICs') in neurology and neuroscience, and is of interest to both neurologists tracking the progress of these methods towards clinical applications, and neuroscientists curious about the most recent advances in this ever-changing field. The explosion of high-throughput assays has introduced large datasets, computational servers, and bioinformatics approaches to neuroscience, and medicine in general. The book includes a rich survey of the most relevant OMICs applications and how they relate to neurology and neuroscience. The reader is given an overview of the method, a perspective on the current and future applications, and published examples illustrating practical uses.

Integrating Omics Data

Author: George C. Tseng
Publisher: Cambridge University Press
ISBN: 1107069114
Size: 74.68 MB
Format: PDF, Mobi
View: 1125
Download and Read
Tutorial chapters by leaders in the field introduce state-of-the-art methods to handle information integration problems of omics data.

Kompendium Systembiologie

Author: Andreas Kremling
Publisher: Springer-Verlag
ISBN: 3834886076
Size: 55.58 MB
Format: PDF
View: 7770
Download and Read
Das Buch beschreibt die Grundlagen der mathematischen Modellierung zellulärer Systeme. Nach einer Klassifikation von Modellen wird schwerpunktmäßig auf deterministische Modelle eingegangen und für alle relevanten zellulären Prozesse entsprechende Gleichungen angegeben. Anschließend werden eine Reihe von Verfahren zur Modellanalyse vorgestellt. Etwas kürzer werden Verfahren zum Reverse Engineering und zur Analyse von Netzwerkgraphen abgehandelt. Am Ende werden noch Verfahren der Parameteridentifikation besprochen.

Informationsmanagement In Der Systembiologie

Author: Silke Eckstein
Publisher: Springer-Verlag
ISBN: 3642182348
Size: 57.34 MB
Format: PDF, ePub, Docs
View: 1050
Download and Read
In der Systembiologie wird untersucht, wie die Komponenten einer Zelle oder eines Organismus Interaktionsnetzwerke bilden und wie diese Zellfunktionen hervorrufen. Das Buch bietet einen Einstieg in die Systembiologie aus der Perspektive der Informatik. Die Autorin stellt die biologischen Grundlagen dar und führt ihre Leser schrittweise von den anfallenden Daten über die zur Verfügung stehenden Datenbanken und deren Integrationsmöglichkeiten hin zu verschiedenen Modellierungsansätzen. Der Band enthält zahlreiche Hinweise zu weiterführender Literatur.

Angewandte Bioinformatik

Author: Paul M. Selzer
Publisher: Springer-Verlag
ISBN: 3662541351
Size: 59.16 MB
Format: PDF, ePub, Docs
View: 452
Download and Read
Für Studierende und Wissenschaftler der Lebenswissenschaften schafft dieses Buch einen schnellen, strukturierten Zugang zur Angewandten Bioinformatik ohne Programmierkenntnisse oder tiefgehende Informatikkenntnisse vorauszusetzen. Es bietet eine Einführung in die tägliche Anwendung der vielfältigen bioinformatischen Werkzeuge und gibt einen ersten Überblick über das sehr komplexe Fachgebiet. Die Kontrolle des vermittelten Stoffs wird durch Übungsbeispiele mit Lösungen gewährleistet. Ein Glossar der zugrundeliegenden Fachtermini sowie ein ausführliches Sachverzeichnis runden das Buch ab. Für die 2. Auflage wurde das Werk umfassend aktualisiert.