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A Practical Guide To Assay Development And High Throughput Screening In Drug Discovery

Author: Taosheng Chen
Publisher: CRC Press
ISBN: 9781420070514
Size: 62.68 MB
Format: PDF
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The development of suitable assays, the integration of appropriate technology, and the effective management of the essential infrastructure are all critical to the success of any high-throughput screening (HTS) endeavor. However, few scientists have the multidisciplinary experience needed to control all aspects of an HTS drug discovery project. A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery integrates the experience of diverse experts who offer fundamental and practical guidance across numerous situations. The book first discusses assay developments for important target classes such as protein kinases and phosphatases, proteases, nuclear receptors, G protein-coupled receptors, ion channels, and heat shock proteins. It next examines assay developments for cell viability, apoptosis, and infectious diseases. The contributors explore the application of emerging technologies and systems, including image-based high content screening, RNA interference, and primary cells. Finally, they discuss the essential components of the integrated HTS process, such as screening automation, compound library management, the screening of natural products from botanical sources, and screening informatics. Designed to motivate researchers to bring further advances to the field, this volume provides practical guidance on how to initiate, validate, optimize, and manage a bioassay intended to screen large collections of compounds. Drawing on the knowledge from experts actively involved in assay development and HTS, this is a resource that is both comprehensive and focused.

Analytical Methods In Combinatorial Chemistry Second Edition

Author: Bing Yan
Publisher: CRC Press
ISBN: 1420003526
Size: 57.89 MB
Format: PDF, Docs
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Since the publication of the benchmark first edition of this book, chemical library and combinatorial chemistry methods have developed into mature technologies. There have also been significant shifts in emphasis in combinatorial synthesis. Reflecting the growth in the field and the heightened focus on select areas, Analytical Methods in Combinatorial Chemistry, Second Edition updates a classic text and captures the current state of these technologies. Written by leaders in the field, this second edition includes several enhancements. A chapter on high-throughput analytical methods and informatics reflects the demand for quality control of library members. A new chapter focuses on high-throughput purification methods. All chapters have been updated with new data. Topics discussed in this second edition include: Properties of solid-phase samples, analytical studies targeted to understand these properties, and resin swelling Fourier Transform Infrared techniques On-support mass spectrometry and nuclear magnetic resonance methods used in the reaction optimization stage Combinatorial library analysis using spectrophotometric, fluorometric, and other methods Quality control of combinatorial libraries High-throughput purification methods Future directions and analytical challenges The coming decade is sure to usher in a new wave of progress in this critical field. This volume provides not only an analysis of the recent developments in analytical methods, technologies and applications; it also provides a window on future possibilities.

The Practice Of Medicinal Chemistry

Author: Camille Georges Wermuth
Publisher: Elsevier
ISBN: 012417213X
Size: 53.79 MB
Format: PDF, Docs
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The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery. With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development. Includes updated and expanded material on systems biology, chemogenomics, computer-aided drug design, and other important recent advances in the field Incorporates extensive color figures, case studies, and practical examples to help users gain a further understanding of key concepts Provides high-quality content in a comprehensive manner, including contributions from international chapter authors to illustrate the global nature of medicinal chemistry and drug development research An image bank is available for instructors at

Essentials Of Genomics And Bioinformatics

Author: Christoph W. Sensen
Publisher: John Wiley & Sons
ISBN: 3527612653
Size: 59.24 MB
Format: PDF, Mobi
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Provides an overview of the rapidly evolving field of genomics with coverage of nucleic acid technologies, proteomics and bioinformatics. It includes chapters on applications in human health, agriculture and comparative genomics and also contains two chapters on the legal and ethical issues of genomics, a topic that is becoming increasingly important as genomics moves out of the laboratory into practical applications.

A Practical Guide To Combinatorial Chemistry

Author: Anthony W. Czarnik
Publisher: Amer Chemical Society
Size: 14.56 MB
Format: PDF, Mobi
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Combinatorial chemistry is the ability to simultaneously synthesize vast numbers of diverse compounds. Its techniques have revolutionized the drug discovery process, and are widely used throughout the biotechnology community. Aimed at a wide audience, this text is a down-to-earth introductionto small molecule combinatorial chemistry. It uses a tutorial approach to provide a detailed survey of solid-phase peptide synthesis and solution-phase synthesis. It also reviews current automated approaches and equipment for both solid- and solution-phase library synthesis.

Drug Discovery And Development

Author: H. P. Rang
Publisher: Churchill Livingstone
Size: 74.84 MB
Format: PDF, ePub
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This title is directed primarily toward health care professionals outside the United States. An ideal introduction to the pharmaceutical industry, this book describes the process of bringing a new drug to the marketplace. It explains why, although thousands of compounds show initial promise, only a small handful will be developed for human clinical trials and perhaps only one will become an approved drug. Describing the huge complexities involved, it shows how new molecular understanding and techniques can make the process more targeted and successful. Includes the new molecular techniques of drug design and development. Discusses current therapeutic needs. Covers pharmacoepidemiology and pharmacoeconomics. Edited by Humphrey Rang, who is also known throughout the world as a co-author of the enormously successful and authoritative textbook, Pharmacology, now in its fifth edition. Foreword by Daniel Vasella, CEO, Novartis International. Includes contributors from both the pharmaceutical industry and universities.