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Developing Therapeutics For Alzheimer S Disease

Author: Michael S. Wolfe
Publisher: Academic Press
ISBN: 0128021640
Size: 56.65 MB
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Developing Therapeutics for Alzheimer's Disease: Progress and Challenges provides a thorough overview of the latest advances toward the development of therapeutics for Alzheimer’s disease, along with the major hurdles that still must be overcome and potential solutions to these problems. Despite the lack of progress toward developing therapeutics that can slow or stop the progression of this disease, important discoveries have been made and many promising approaches are advancing in preclinical studies and clinical trials. This book outlines the special challenges related to specific targets and approaches, while presenting a realistic, comprehensive and balanced view of drug discovery and development in this area. Written by international leaders in the field, the book assesses prospects for the emergence of effective agents and allows readers to better understand the challenges, failures, and future potential for research in Alzheimer’s disease. This book is a valuable resource to academic scientists carrying out translational research in Alzheimer’s disease, industrial scientists engaged in Alzheimer's drug discovery, executives in biopharmaceutical companies making strategic decisions regarding the direction of internal research and potential outside partnerships, and graduate-level students pursuing courses on Alzheimer's therapeutics. Provides a realistic but promising assessment of the potential of various therapeutic approaches to Alzheimer’s disease Focuses primarily on neuroprotective agents and cognitive enhancers, as well as approaches to targeting the amyloid B-peptide, tau and Apolipoprotein E Discusses alternative approaches, preclinical and clinical development issues, related biomarkers and diagnostics, and prevention and nonpharmacological approaches

Alzheimer S Disease

Author: Renee D. Wegrzyn
Publisher: CRC Press
ISBN: 1439827095
Size: 27.98 MB
Format: PDF
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In recent years, a tremendous amount of effort has been focused on better understanding the fundamentals of Alzheimer’s disease (AD) to facilitate early and accurate diagnosis and appropriately targeted therapeutic treatments. Alzheimer’s Disease: Targets for New Clinical, Diagnostic, and Therapeutic Strategies provides a detailed synopsis of the current state of the art of diagnostics and therapeutics and identifies emerging technologies and molecules that show promise in the management and treatment of AD. With contributions from experts drawn from academia, clinical practice, and the biotechnology and pharmaceutical industries, the book explores: The basis of AD and the role of Aβ oligomers in development of disease Existing and emerging in vitro biomarker-based methodologies for the diagnosis of AD, focusing on genetic, biochemical, and conformational strategies In vivo imaging diagnostic approaches Evolving diagnostic criteria, health regulatory guidelines, biomarkers in clinical trials, and available and emerging therapies Recent progress in small-molecule disease-modifier drug discovery efforts for AD, specifically in the areas of Aβ, tau, and emerging neuroprotective/neurorepair approaches How a case study of AD raises issues regarding clinical and pathologic criteria, risk factors, and the amyloid hypothesis The molecular conformational factors that govern the pathogenicity of aggregating proteins, and how these factors could represent new targets for disease-modifying therapies The latest epidemiological, pathological, biochemical, and behavioral studies that may shed some light on the risk of developing AD and similar dementias after traumatic brain injury Examining current hypotheses and suggesting possible new approaches to therapeutic clinical applications, this volume paves the way for a robust pipeline of therapeutics to combat not only AD, but a whole host of other neurodegenerative diseases.

Progress Report On Alzheimer S Disease 2009 Translating New Knowledge

Author: Barry Leonard
Publisher: DIANE Publishing
ISBN: 1437944809
Size: 10.22 MB
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The U.S. investment in Alzheimer¿s research through the Nat. Inst. of Health (NIH) has resulted in accelerating progress on several research fronts and laid the groundwork for future discovery. This report highlights key findings related to: discovery of new genes and biological mechanisms that cause Alzheimer¿s disease; earlier disease detection using neuro-imaging and biomarkers; links between Alzheimer¿s and other age-related diseases; rapid translation of lab findings to potential treatments; lifestyle factors that may protect against the disease; successful cognitive aging; clinical trials underway now to prevent or treat Alzheimer¿s and cognitive decline; research-tested strategies to support caregivers. Illus. This is a print on demand report.

Research Progress In Alzheimer S Disease And Dementia

Author: Miao-Kun Sun
Publisher: Nova Publishers
ISBN: 9781600219603
Size: 51.54 MB
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Alzheimer's disease (AD), the most common form of neurodegenerative disorder in the elderly, is characterised pathologically by extracellular amyloid plaques and intracellular neurofibrillary tangles, pathophysiologically by synaptic dysfunction, and clinically by a progressive decline in cognition. Currently, AD has no cure and its prevalence is predicted to triple by 2050 with the rapid increase in the ageing population, unless more effective treatments are developed. Since the publication of the second book volume, the rapid progress in the research fields of AD and dementia continues through the intensive efforts of research scientists worldwide.This third book volume contains 15 chapters, bringing together a presentation of research frontiers in current AD/dementia research. The topics include molecular genetics of AD, gene expression abnormalities in AD progression, presenilins, taupathy in AD, single - induced(neuron gene expression abnormalities in AD, intracellular A neurodegeneration, roles of lipoprotein receptors in AD onset and progression, cholesterol and tau hyperphosphorylation, AD diagnostics and therapeutic strategies, in vivo visualisation of amyloid-like structures, cathepsin B, antiamyloidogenesis and neuroprotection, environmental enrichment, Fragile X mental retardation gene and dementia, category learning in Parkinson's disease, cerebrovascular disease and dementia, and dementia and hypertension.These chapters cover current advances in our understanding of the pathogenic mechanisms underlying AD and dementia, in the diagnosis of early AD and dementia, and in the development of therapeutic agents that target memory-relevant AD pathogenesis. The book will be highly valuable to students and scientists worldwide who are interested in the scientific research progress in AD and dementia.

Stahl S Illustrated Alzheimer S Disease And Other Dementias

Author: Stephen Stahl
Publisher: Cambridge University Press
ISBN: 1108577865
Size: 10.39 MB
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The term “dementia” describes a collection of symptoms including cognitive dysfunction, memory loss, language and communication issues, and behavioural symptoms. There are numerous causes of dementia and, worldwide, over 35 million individuals have some form of dementia. This book describes the most common causes of dementia, reviews best practices for differentially diagnosing dementia, as well as management strategies to help improve quality of life for both patients and carers. Stahl's Illustrated Alzheimer's Disease and Other Dementias is a concise guide, with all concepts illustrated by full-color figures and tables, that will be familiar to readers of Stahl's Essential Psychopharmacology and The Prescriber's Guide. The visual learner will find that this book makes psychopharmacological concepts easier to master, and the non-visual learner will enjoy this book's short explanations of complex psychopharmacological concepts. Each chapter builds upon previous ones, synthesizing information about basic biology, diagnostics, treatment plans, complications, and comorbidities.

Neuroprotection In Alzheimer S Disease

Author: Illana Gozes
Publisher: Academic Press
ISBN: 0128037121
Size: 34.41 MB
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Neuroprotection in Alzheimer’s Disease offers a translational point-of-view from both basic and clinical standpoints, putting it on the cusp for further clinical development with its emphasis on nerve cell protection, including the accumulation of knowledge from failed clinical trials and new advances in disease management. This book brings together the latest findings, both basic, and clinical, under the same cover, making it easy for the reader to obtain a complete overview of the state-of-the-field and beyond. Alzheimer's disease is the most common form of dementia, accounting for 60 to 80 percent of dementia cases. It is a progressive brain disease that slowly destroys memory, thinking skills, and eventually, even the ability to carry out the simplest tasks. It is characterized by death of synapses coupled to death nerve cells and brain degeneration which is manifested by loss of cognitive abilities. Understanding neuroprotection in Alzheimer’s disease will pave the path to better disease management and novel therapeutics. Comprehensive reference detailing neuroprotection in Alzheimer’s Disease, with details on nerve cell protection and new advances in disease management Combines the knowledge and points-of-view of both medical doctors and basic scientists, putting the subject at the forefront for further clinical development Edited by one of the leading researchers in Alzheimer’s Disease

Alzheimers Disease

Author: Margaret Strock
Publisher: DIANE Publishing
ISBN: 9780788127830
Size: 30.98 MB
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Covers: what is Alzheimer's; the diagnosis of Alzheimer's Disease; the search for the cause of Alzheimer's Disease; the treatment of Alzheimer's Disease; and hope for the future through research. Glossary, references, and sources of help. Illustrated. Also includes a 28-page guide, "Early Identification of Alzheimer's Disease and Related Dementias."

Alzheimer S Disease

Author: Khalid Iqbal
Publisher: John Wiley & Sons Incorporated
Size: 33.13 MB
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Alzheimer’s Disease: Basic Mechanisms, Diagnosis and Therapeutic Strategies Edited by Khalid Iqbal New York State Institute for Basic Research, New York, USA Donald R.C. McLachlan Centre for Research on Neurodegenerative Diseases, University of Toronto, Canada Bengt Winblad Department of Geriatric Medicine, Karolinska Institute, Stockholm, Sweden and Henry M. Wisniewski New York State Institute for Basic Research, New York, USA As human longevity continues to be extended, so will the impact of age-associated dementia on individual lives and society. Although recognized as one of the most devastating diseases of the human brain, the etiology and pathogenesis of Alzheimer’s disease are still poorly understood. Continued research is required both into the basic mechanisms of the condition and into developing diagnostic and therapeutic strategies in the clinic. Presented here is a wide-ranging, authoritative and comprehensive coverage of the most recent and significant advances in basic research and clinical investigations of Alzheimer’s disease. Areas represented include neuroimaging, brain energy metabolism, structural and molecular neuropathology, mechanisms of neuronal degeneration, role of brain amyloidosis, risk factors and epidemiology, environmental factors, genetic mechanisms, biomarkers, animal models and the clinical pharmacology of current and future therapeutic strategies. Contributions are drawn from the major research groups around the world, providing an invaluable information and reference source to both basic researchers and clinicians providing primary care for the unfortunate victims of Alzheimer’s disease. Titles of related interest from Wiley: Dahlem LS43: Etiology of Dementia of Alzheimer’s Type 0 471 92075 4 1988 Giaquinto: Aging and the Nervous System 0 471 91835 0 1988 Iqbal et al.: Alzheimer’s Disease and Related Disorders 0 471 56228 9 1989 Hindmarch, Hippius and Wilcock: Dementia: Molecules, Methods and Measures due Summer 1991


Author: Varghese John
Publisher: John Wiley & Sons
ISBN: 9780470594070
Size: 62.33 MB
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BACE inhibitors and their use in the treatment of Alzheimer's Disease BACE (β-site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development of BACE inhibitors shows great potential as a therapy for the disease. BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease covers virtually all aspects of BACE from initial identification, discovery of inhibitors, and challenges in clinical development, while providing a global understanding essential for productive and successful drug discovery. This book details the story of the discovery of BACE and its role in AD and comprehensively discusses: The development of BACE inhibitors as therapeutics for Alzheimer's disease The research that led to the identification of BACE New BACE inhibitors currently being clinically tested ADME (absorption, distribution, metabolism, excretion) and clinical trial design—topics not addressed in current field literature Cutting-edge technology such as high-throughput screening, structure-based drug design, and QSAR in context of BACE inhibitors and Alzheimer's drug discovery Other approaches to BACE inhibition based on interaction with the precursor protein APP By enhancing the reader's understanding of the various aspects of the BACE drug-discovery process, this much-needed reference will serve as a key resource for all scientists involved in Alzheimer's research—and inspire new approaches to treatment of AD.