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Discrete Event Simulation For Health Technology Assessment

Author: J. Jaime Caro
Publisher: CRC Press
ISBN: 1482218259
Size: 41.96 MB
Format: PDF, ePub, Mobi
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Discover How to Apply DES to Problems Encountered in HTA Discrete event simulation (DES) has traditionally been used in the engineering and operations research fields. The use of DES to inform decisions about health technologies is still in its infancy. Written by specialists at the forefront of this area, Discrete Event Simulation for Health Technology Assessment is the first book to make all the central concepts of DES relevant for health technology assessment (HTA). Accessible to beginners, the book requires no prerequisites and describes the concepts with as little jargon as possible. The book first covers the essential concepts and their implementation. It next provides a fully worked out example using both a widely available spreadsheet program (Microsoft Excel) and a popular specialized simulation package (Arena). It then presents approaches to analyze the simulations, including the treatment of uncertainty; tackles the development of the required equations; explains the techniques to verify that the models are as efficient as possible; and explores the indispensable topic of validation. The book also covers a variety of non-essential yet handy topics, such as the animation of a simulation and extensions of DES, and incorporates a real case study involving screening strategies for breast cancer surveillance. This book guides you in leveraging DES in your assessments of health technologies. After reading the chapters in sequence, you will be able to construct a realistic model designed to help in the assessment of a new health technology.

Cost Effectiveness Modelling For Health Technology Assessment

Author: Richard Edlin
Publisher: Springer
ISBN: 3319157442
Size: 72.17 MB
Format: PDF, Kindle
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This book provides an introduction to decision analytic cost-effectiveness modelling, giving the theoretical and practical knowledge required to design and implement analyses that meet the methodological standards of health technology assessment organisations. The book guides you through building a decision tree and Markov model and, importantly, shows how the results of cost-effectiveness analyses are interpreted. Given the complex nature of cost-effectiveness modelling and the often unfamiliar language that runs alongside it, we wanted to make this book as accessible as possible whilst still providing a comprehensive, in-depth, practical guide that reflects the state of the art – that includes the most recent developments in cost-effectiveness modelling. Although the nature of cost effectiveness modelling means that some parts are inevitably quite technical, across the 13 chapters we have broken down explanations of theory and methods into bite-sized pieces that you can work through at your own pace; we have provided explanations of terms and methods as we use them. Importantly, the exercises and online workbooks allow you to test your skills and understanding as you go along.

Hospital Based Health Technology Assessment

Author: Laura Sampietro-Colom
Publisher: Springer
ISBN: 3319392050
Size: 17.55 MB
Format: PDF, Docs
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A timely work describing how localized hospital-based health technology assessment (HB-HTA) complements general, ‘arms-length’ HTA agency efforts, and what has been the collective global impact of HB-HTA across the globe. While HB-HTA has gained significant momentum over the past few years, expertise in the field, and information on the operation and organization of HB-HTA, has been scattered. This book serves to bring this information together to inform those who are currently working in the field of HTA at the hospital, regional, national or global level. In addition, this book is intended for decision-makers and policy-makers with a stake in determining the uptake and decommissioning of new and established technologies in the hospital setting. HTA has traditionally been performed at the National/Regional level by HTA Agencies, typically linked to governments. Yet hospitals are the main entry door for most health technologies (HTs). Hospital decision-makers must undertake multiple high stakes investment and disinvestment decisions annually for innovative HTs, usually without adequate information. Despite the existence of arms-length HTA Agencies, inadequate information is available to hospital decision-makers either because relevant HTA reports are not yet released at the time of entry of new technologies to the field, or because even when the report exists, the information contained is insufficient to clarify the contextualized informational needs of hospital decision makers. Therefore, there has recently been a rising trend toward hospital-based HTA units and programs. These units/programs complement the work of National/Regional HTA Agencies by providing the key and relevant evidence needed by hospital decision makers in their specific hospital context, and within required decision-making timelines. The emergence of HB-HTA is creating a comprehensive HTA ecosystem across health care levels, which creates better bridges for knowledge translation through relevance and timeliness.

Economic Evaluation Of Cancer Drugs

Author: Iftekhar Khan
Publisher: CRC Press
ISBN: 1498761313
Size: 38.37 MB
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Cancer is a major healthcare burden across the world and impacts not only the people diagnosed with various cancers but also their families, carers, and healthcare systems. With advances in the diagnosis and treatment, more people are diagnosed early and receive treatments for a disease where few treatments options were previously available. As a result, the survival of patients with cancer has steadily improved and, in most cases, patients who are not cured may receive multiple lines of treatment, often with financial consequences for the patients, insurers and healthcare systems. Although many books exist that address economic evaluation, Economic Evaluation of Cancer Drugs using Clinical Trial and Real World Data is the first unified text that specifically addresses the economic evaluation of cancer drugs. The authors discuss how to perform cost-effectiveness analyses while emphasising the strategic importance of designing cost-effectiveness into cancer trials and building robust economic evaluation models that have a higher chance of reimbursement if truly cost-effective. They cover the use of real-world data using cancer registries and discuss how such data can support or complement clinical trials with limited follow up. Lessons learned from failed reimbursement attempts, factors predictive of successful reimbursement and the different payer requirements across major countries including US, Australia, Canada, UK, Germany, France and Italy are also discussed. The book includes many detailed practical examples, case studies and thought-provoking exercises for use in classroom and seminar discussions. Iftekhar Khan is a medical statistician and health economist and a lead statistician at Oxford Unviersity’s Center for Statistics in Medicine. Professor Khan is also a Senior Research Fellow in Health Economics at University of Warwick and is a Senior Statistical Assessor within the Licensing Division of the UK Medicine and Health Regulation Agency. Ralph Crott is a former professor in Pharmacoeconomics at the University of Montreal in Quebec, Canada and former head of the EORTC Health Economics Unit and former senior health economist at the Belgian HTA organization. Zahid Bashir has over twelve years experience working in the pharmaceutical industry in medical affairs and oncology drug development where he is involved in the design and execution of oncology clinical trials and development of reimbursement dossiers for HTA submission.

Simulation And Modeling Methodologies Technologies And Applications

Author: Mohammad S. Obaidat
Publisher: Springer Science & Business Media
ISBN: 3319035819
Size: 38.50 MB
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This book includes extended and revised versions of a set of selected papers from the 2012 International Conference on Simulation and Modeling Methodologies, Technologies and Applications (SIMULTECH 2012) which was sponsored by the Institute for Systems and Technologies of Information, Control and Communication (INSTICC) and held in Rome, Italy. SIMULTECH 2012 was technically co-sponsored by the Society for Modeling & Simulation International (SCS), GDR I3, Lionphant Simulation, Simulation Team and IFIP and held in cooperation with AIS Special Interest Group of Modeling and Simulation (AIS SIGMAS) and the Movimento Italiano Modellazione e Simulazione (MIMOS).

Decision Modelling For Health Economic Evaluation

Author: Andrew Briggs
Publisher: OUP Oxford
ISBN: 0191004952
Size: 34.92 MB
Format: PDF, ePub, Mobi
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In financially constrained health systems across the world, increasing emphasis is being placed on the ability to demonstrate that health care interventions are not only effective, but also cost-effective. This book deals with decision modelling techniques that can be used to estimate the value for money of various interventions including medical devices, surgical procedures, diagnostic technologies, and pharmaceuticals. Particular emphasis is placed on the importance of the appropriate representation of uncertainty in the evaluative process and the implication this uncertainty has for decision making and the need for future research. This highly practical guide takes the reader through the key principles and approaches of modelling techniques. It begins with the basics of constructing different forms of the model, the population of the model with input parameter estimates, analysis of the results, and progression to the holistic view of models as a valuable tool for informing future research exercises. Case studies and exercises are supported with online templates and solutions. This book will help analysts understand the contribution of decision-analytic modelling to the evaluation of health care programmes. ABOUT THE SERIES: Economic evaluation of health interventions is a growing specialist field, and this series of practical handbooks will tackle, in-depth, topics superficially addressed in more general health economics books. Each volume will include illustrative material, case histories and worked examples to encourage the reader to apply the methods discussed, with supporting material provided online. This series is aimed at health economists in academia, the pharmaceutical industry and the health sector, those on advanced health economics courses, and health researchers in associated fields.

Advances In Parenteral Nutrition Research And Application 2012 Edition

Publisher: ScholarlyEditions
ISBN: 148163836X
Size: 77.64 MB
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Advances in Parenteral Nutrition Research and Application / 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Parenteral Nutrition in a compact format. The editors have built Advances in Parenteral Nutrition Research and Application / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Parenteral Nutrition in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Parenteral Nutrition Research and Application / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at

Operational Research For Health Policy Making Better Decisions

Author: Sally Brailsford
Publisher: Peter Lang
ISBN: 9783039110933
Size: 10.98 MB
Format: PDF, Kindle
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ORAHS, the Working Group on Operational Research Applied to Health Services, is a special-interest group of EURO (the European Association of OR Societies). ORAHS meets every year in a different host country. The objectives of the group include communication of ideas, knowledge and experience concerning the application of Operational Research approaches and methods to problems in the health services area; mutual support between members; and collaboration on joint projects. The 31st meeting of ORAHS was held in 2005 at the University of Southampton, UK. A total of forty-one scientific papers were presented, nineteen of which are contained in this volume. The application areas covered include resource allocation, performance measurement and disease modelling, from within Europe and beyond. The approaches used range from mathematical optimization, simulation and statistical modelling through to -soft- OR. These proceedings provide a broad perspective on current research in this area across Europe and beyond."

Decision Technology

Author: Matthew Liberatore
Publisher: John Wiley & Sons Incorporated
Size: 66.99 MB
Format: PDF, Docs
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The authors use Lingo, Expert Choice, Extend, and MS Project 2000 to introduce decision technology. This offers a flexible approach to math programming formulations.