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Heart Valves

Author: Paul A. Iaizzo
Publisher: Springer Science & Business Media
ISBN: 1461461448
Size: 36.12 MB
Format: PDF
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Cardiovascular disease is the major cause of morbidity and mortality worldwide. While the past 40 years have brought major progress in cardiac valve repair and replacement, there remain large patient populations that do not receive such therapies. This, in turn, implies a great need for future basic, applied, and clinical research and, ultimately, therapeutic developments. Heart Valves is a state-of-the-art handbook dedicated to: 1) cardiac valve anatomy, 2) models for testing and research methods; 3) clinical trials; and 4) clinical needs and applications.

Transcatheter Valve Therapies

Author: Christoph Huber
Publisher: CRC Press
ISBN: 1439810826
Size: 66.69 MB
Format: PDF
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The landscape of cardiac surgery is changing, as is the field of interventional cardiology. The idea of accessing and replacing a failing valve through the patients vasculature has become the most rapidly expanding therapy of choice in cardiovascular disease. Transcatheter Valve Therapies chronicles the astonishing advances that have taken place in the field and prepares readers for the challenging future of cardiac valve therapies. Designed to meet the growing needs of cardiologists, cardiac surgeons, anesthetists, and general practitioners, the book covers all aspects from logistic needs to clinical outcomes. It provides a comprehensive overview of transcatheter valve therapies and the necessary understanding for a successful clinical introduction at individual institutions. Topics include: Epidemiologic considerations Aspects of balloon aortic valvuloplasty as a stand-alone procedure or as part of the transcatheter valve replacement The history of how transcatheter valve therapies were implemented into surgical practice New imaging modalities The particularities of transcatheter access Aortic root anatomy Emerging technologies and future design improvements Development steps of aortic devices and potential solutions for transcatheter tricuspid, mitral, and pulmonary valve replacement The rigorous testing requirements for endovascular medical devices Clinical results of aortic transcatheter valve therapies in easy accessible text and table formats The future of transcatheter valve therapies All topics are discussed based on the author’s own clinical and experimental experience in the field. This volume is essential for anyone involved in transcatheter valve implantation, clinicians wishing to become more involved in improving transcatheter valve therapies, and researchers engaged in building and creating new medical technologies to shape the cardiovascular landscape of the future.

Cardiac Reconstructions With Allograft Tissues

Author: Richard A. Hopkins
Publisher: Springer Science & Business Media
ISBN: 9780387949628
Size: 47.94 MB
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Cryopreserved allograft tissues are now standard materials for the reconstructive cardiac surgeon. Since publication of the first edition ("Cardiac Reconstructions with Allograft Valves") in 1989, the field has progressed dramatically with increased clinical use of cardiovascular allograft tissues, with the development of new surgical techniques, and with advances in the understanding of the fundamentals of valve transplantation biology and cryopreservation. As a result, over two-thirds of the present volume represents new material. Fifty-six authors bring their expertise to thirteen comprehensive, lavishly illustrated sections which discuss the principles of the use of homograft valves, major clinical series of homograft valves for both left and right ventricular outflow tracts, cryopreserved allograft tissue for cardiac reconstruction, cell biology of heart valve leaflets, cryobiology of heart valve preservation, morphological, biochemical, and explant pathology studies of allograft heart valves, allograft valve banking, as well as detailed explanation of surgical techniques for valve and root methods for left and right ventricular outflow tract reconstructions, the Ross operation and variants, and complex reconstructions. A final section presents potential future directions for the field. Over 400 illustrations, created expressly for this book, depict the surgical techniques from the perspective of the surgeon standing at the operating table. All surgeons performing pediatric and/or adult valve replacements and reconstructive cardiac surgeries will benefit from the described methods. Cardiothoracic residents and cardiologists will also find the text useful. It will provide the surgeon with an enhanced understanding of the biological and material properties of allografts and increased familiarity with the range of surgical techniques applicable for the use of these valves, particularly in the successful management of challenging cardiac reconstructions.>

Transcatheter Valve Repair

Author: Ziyad M. Hijazi
Publisher: CRC Press
ISBN: 9781841844725
Size: 23.81 MB
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Transcatheter Valve Repair discusses all aspects related to percutaneous and established valve repair methods. The book is divided into few major sections covering all four valves and other topics. Each section contains several chapters discussing everything related to that valve. Beginning with the pulmonary valve, since it was the first valve to be tackled in the catheterization laboratory, and then moving to the aortic, then the mitral and then finally end with the tricuspid valve. 1.5M US citizens alone have some degree of aortic valve stenosis, with half (750K) requiring aortic valve replacement. Aortic valve replacement, on the whole, is performed by surgeons, requiring bypass machines and technicians, as well as the usual operating team. The operation is expensive and occupies a considerable amount of operating room time. Mostly, the aortic valve is calcified and the usual option available to patients is valve replacement with a variety of choices, ranging from porcine valves to synthetic, for which there are many manufacturers. It should be noted that the aortic valve is the most problematic of valves. Percutaneous procedures are the answer. The bottom line is that given the growing elderly population, many more patients will require valve repair, thus increasing health care costs with not only surgical operations but also hospitalisation. Percutanous valve repair, whilst requiring a cath lab team, does not involve bypass machines nor extended hospitalisation. Like percutaneous transluminal coronary artery interventions (PTCA) has replaced coronary artery bypass grafts (once the golden standard), and now stenting having replaced PTCA and its balloons. We now see drug eluting stents replacing ordinary stents (though at a much higher cost. There will be a huge movement toward percutanous valve repair, which should presumably cut costs but also morbidity and mortality.

Biomaterials Science

Author: Buddy D. Ratner
Publisher: Academic Press
ISBN: 008087780X
Size: 31.85 MB
Format: PDF
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The revised edition of this renowned and bestselling title is the most comprehensive single text on all aspects of biomaterials science. It provides a balanced, insightful approach to both the learning of the science and technology of biomaterials and acts as the key reference for practitioners who are involved in the applications of materials in medicine. Over 29,000 copies sold, this is the most comprehensive coverage of principles and applications of all classes of biomaterials: "the only such text that currently covers this area comprehensively" - Materials Today Edited by four of the best-known figures in the biomaterials field today; fully endorsed and supported by the Society for Biomaterials Fully revised and expanded, key new topics include of tissue engineering, drug delivery systems, and new clinical applications, with new teaching and learning material throughout, case studies and a downloadable image bank

Tissue Engineering And Artificial Organs

Author: Joseph D. Bronzino
Publisher: CRC Press
ISBN: 9780849321238
Size: 45.60 MB
Format: PDF, Kindle
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Over the last century, medicine has come out of the "black bag" and emerged as one of the most dynamic and advanced fields of development in science and technology. Today, biomedical engineering plays a critical role in patient diagnosis, care, and rehabilitation. As such, the field encompasses a wide range of disciplines, from biology and physiology to material science and nanotechnology. Reflecting the enormous growth and change in biomedical engineering during the infancy of the 21st century, The Biomedical Engineering Handbook enters its third edition as a set of three carefully focused and conveniently organized books. Reviewing applications at the leading edge of modern biomedical engineering, Tissue Engineering and Artificial Organs explores transport phenomena, biomimetics systems, biotechnology, prostheses, artificial organs, and ethical issues. The book features approximately 90% new material in the tissue engineering section, integrates coverage of life sciences with a new section on molecular biology, and includes a new section on bionanotechnology. Prominent leaders from around the world share their expertise in their respective fields with many new and updated chapters. New technologies and methods spawned by biomedical engineering have the potential to improve the quality of life for everyone, and Tissue Engineering and Artificial Organs sheds light on the tools that will enable these advances.

Echocardiography

Author: Petros Nihoyannopoulos
Publisher: Springer Science & Business Media
ISBN: 9781848822931
Size: 59.93 MB
Format: PDF, ePub, Docs
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As increasing emphasis is placed on evidence-based medicine and the need to a rapid and clinically effective diagnosis of cardiac disease, so echocardiography is ever-more present at the forefront of cardiology. This book represents the current knowledge in the technique of cardiology and is designed to guide the resident and fellow through the most common applications of echocardiography while touching on some of the less often seen echocardiographic diagnoses.

Comprehensive Biomaterials

Author: Paul Ducheyne
Publisher: Elsevier
ISBN: 0080552943
Size: 29.17 MB
Format: PDF
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Comprehensive Biomaterials brings together the myriad facets of biomaterials into one, major series of six edited volumes that would cover the field of biomaterials in a major, extensive fashion: Volume 1: Metallic, Ceramic and Polymeric Biomaterials Volume 2: Biologically Inspired and Biomolecular Materials Volume 3: Methods of Analysis Volume 4: Biocompatibility, Surface Engineering, and Delivery Of Drugs, Genes and Other Molecules Volume 5: Tissue and Organ Engineering Volume 6: Biomaterials and Clinical Use Experts from around the world in hundreds of related biomaterials areas have contributed to this publication, resulting in a continuum of rich information appropriate for many audiences. The work addresses the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, and strategic insights for those entering and operational in diverse biomaterials applications, research and development, regulatory management, and commercial aspects. From the outset, the goal was to review materials in the context of medical devices and tissue properties, biocompatibility and surface analysis, tissue engineering and controlled release. It was also the intent both, to focus on material properties from the perspectives of therapeutic and diagnostic use, and to address questions relevant to state-of-the-art research endeavors. Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance as well as future prospects Presents appropriate analytical methods and testing procedures in addition to potential device applications Provides strategic insights for those working on diverse application areas such as R&D, regulatory management, and commercial development

Learning From Nature How To Design New Implantable Biomaterials From Biomineralization Fundamentals To Biomimetic Materials And Processing Routes

Author: Rui L. Reis
Publisher: Springer Science & Business Media
ISBN: 140202648X
Size: 29.69 MB
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The development of materials for any replacement or regeneration application should be based on the thorough understanding of the structure to be substituted. This is true in many fields, but particularly exigent in substitution and regeneration medicine. The demands upon the material properties largely depend on the site of application and the function it has to restore. Ideally, a replacement material should mimic the living tissue from a mechanical, chemical, biological and functional point of view. Of course this is much easier to write down than to implement in clinical practice. Mineralized tissues such as bones, tooth and shells have attracted, in the last few years, considerable interest as natural anisotropic composite structures with adequate mechanical properties. In fact, Nature is and will continue to be the best materials scientist ever. Who better than nature can design complex structures and control the intricate phenomena (processing routes) that lead to the final shape and structure (from the macro to the nano level) of living creatures? Who can combine biological and physico-chemical mechanisms in such a way that can build ideal structure-properties relationships? Who, else than Nature, can really design smart structural components that respond in-situ to exterior stimulus, being able of adapting constantly their microstructure and correspondent properties? In the described philosophy line, mineralized tissues and biomineralization processes are ideal examples to learn-from for the materials scientist of the future.

Interventions In Structural Valvular And Congenital Heart Disease

Author: Horst Sievert
Publisher: CRC Press
ISBN: 1482215640
Size: 36.74 MB
Format: PDF, Mobi
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At one time, many children born with congenital heart disease (CHD) suffered from issues that carried fatal prognoses. But that's changing, thanks to technological advances. Interventions in Structural, Valvular, and Congenital Heart Disease, Second Edition guides you throught the interventional treatment of congenital, valvular, and stru