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Patch Clamping

Author: Areles Molleman
Publisher: John Wiley & Sons
ISBN: 0470856513
Size: 16.79 MB
Format: PDF, ePub
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Patch clamping is a widely applied electrophysiological technique for the study of ion channels; membrane proteins that regulate the flow of ions across cellular membranes and therefore influence the physiology of all cells. Patch Clamping aims to cover the basic principles and practical applications of this important technique. Starting with a review of the history of patch clamping, the text then goes on to cover the basic principles, platforms, equipment and environmental control, and will also include coverage of preparation types, recording modes and analysis of results. This book will explain the basic principles and practical application of patch clamp electrophysiology Written in a non-technical style to ensure its broad appeal to novice users Takes a practical approach This self-contained guide provides everything a practising patch clamp electrophysiologist needs to know to master this technique, including an overview of membrane biophysics, standard experimental design, data analysis, and technical concerns

Gigaseal Formation In Patch Clamping

Author: Majid Malboubi
Publisher: Springer Science & Business Media
ISBN: 3642391281
Size: 45.96 MB
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This book presents an investigation of gigaseal formation using micro/nanotechnology. The aims of the book are twofold. First, it explains the mechanisms of gigaseal formation using the latest discoveries. Second, it provides practical techniques for frequent formation of high resistance seals. The formation of a high-resistance electrical seal, also known as a gigaseal, between a cell membrane and a glass micropipette tip is essential in patch-clamp experiments. Even though four decades have passed since the introduction of the patch-clamping technique by Neher and Sakmann, gigaseal formation remains an obstacle in developing the high-throughput ion channel screening systems required by the pharmaceutical industry. Here the authors share their latest methods for achieving gigaseal formation and describe techniques that are highly desirable at both research and industrial levels. Nanotechnology has been found to be a powerful tool for studying and modifying glass micropipettes and in tackling the problem of gigaseal formation.


Author: Miles Hacker
Publisher: Academic Press
ISBN: 9780080919225
Size: 68.39 MB
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Pharmacology meets the rapidly emerging needs of programs training pharmacologic scientists seeking careers in basic research and drug discovery rather than such applied fields as pharmacy and medicine. While the market is crowded with many clinical and therapeutic pharmacology textbooks, the field of pharmacology is booming with the prospects of discovering new drugs, and virtually no extant textbook meets this need at the student level. The market is so bereft of such approaches that many pharmaceutical companies will adopt Hacker et al. to help train new drug researchers. The boom in pharmacology is driven by the recent decryption of the human genome and enormous progress in controlling genes and synthesizing proteins, making new and even custom drug design possible. This book makes use of these discoveries in presenting its topics, moving logically from drug receptors to the target molecules drug researchers seek, covering such modern topics along the way as side effects, drug resistance, pharmacogenomics, and even nutriceuticals, one in a string of culminating chapters on the drug discovery process. The book is aimed at advanced undergraduates and beginning graduate students in medical, pharmacy, and graduate schools looking for a solid introduction to the basic science of pharmacology and envisioning careers in drug research. Uses individual drugs to explain molecular actions Full color art program explains molecular and chemical concepts graphically Logical structure reflecting the current state of pharmacology and translational research Covers such intricacies as drug resistance and cell death Consistent format across chapters and pedagogical strategies make this textbook a superior learning tool

Electronic Engineering And Computing Technology

Author: Len Gelman
Publisher: Springer Science & Business Media
ISBN: 9789048187768
Size: 11.23 MB
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Electronic Engineering and Computing Technology contains sixty-one revised and extended research articles written by prominent researchers participating in the conference. Topics covered include Control Engineering, Network Management, Wireless Networks, Biotechnology, Signal Processing, Computational Intelligence, Computational Statistics, Internet Computing, High Performance Computing, and industrial applications. Electronic Engineering and Computing Technology will offer the state of art of tremendous advances in electronic engineering and computing technology and also serve as an excellent reference work for researchers and graduate students working with/on electronic engineering and computing technology.

Neural Stem Cell Assays

Author: Navjot Kaur
Publisher: John Wiley & Sons
ISBN: 1118308271
Size: 48.78 MB
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Neural stem cells offer a valuable model system for delineating the cellular and developmental processes in normal and diseased states of the central nervous system. In particular, neural stem cells have huge potential in regenerative medicine, owing to their expansion capability in culture and the ability to differentiate into multiple sub-neural lineages. Neural Stem Cell Assays provides a detailed and comprehensive review of the basic methods for neural stem cell cultures. Including an overview of progress in the field over the past decade, Neural Stem Cell Assays is a one-stop reference for consistent methods and reliable tools that span the entire assay work flow, from isolation or generation of neural stem cells to characterization, manipulation and final application of neural stem cells in disease paradigms such as Parkinson's disease, multiple sclerosis and amyotrophic lateral sclerosis. An excellent source of information for academic, pharmaceutical and biotechnology researchers who are new to the neural stem cell field, Neural Stem Cell Assays is an invaluable to experienced users who wish to integrate newly developed tools and technologies into their workflow. The book also covers important course material for students at the undergraduate and graduate level who are learning the basics of neural stem cell cultures, and differentiation to sub-neural lineages.

On Chip Cryopreservation And Dna Transformation Of Cells

Author: Sha Li
Size: 37.15 MB
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This dissertation presents several key technologies toward a micro total analysis system on a single chip. These technologies include on-chip cryopreservation, DNA transformation and electrophysiological analysis of living cells as well as a proof-of-concept demonstration by utilizing a frozen water process to make microfluidic devices.

Patente Marken Design Von A Bis Z

Author: Volker Münch
Publisher: VCH
ISBN: 9783527323715
Size: 13.57 MB
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Patentrecht, Markenrecht und Designschutz bilden einen Bereich, der ständigem Wandel unterworfen ist. Selbst für Spezialisten ist es zur Herausforderung geworden, Rechte und Forschungsergebnisse zu schützen in einem internationalen Umfeld, das täglich komplexer wird. Basierend auf dem 1991 erschienenen erfolgreichen Werk 'Patentbegriffe von A bis Z' und ergänzt um ein dreisprachiges Fachwortverzeichnis, führt das hoch vernetzte Glossar durch den Dschungel der Begrifflichkeiten und berücksichtigt dabei alle aktuellen rechtlichen Änderungen wie: einheitliche Marken für die EU, Auswirkung von EU-Richtlinien auf nationale Patentsysteme, EPÜ ab Dezember 2007, weltweite Harmonisierung des gewerblichen Rechtsschutzes (TRIPS-Abkommen) inklusive Asien unter besonderer Berücksichtigung Japans, Änderung des US-Patentrechts, Gemeinsamkeiten und Unterschiede des Rechts in verschiedenen Ländern. Mit eingängigen Beispielen und kompetenten Erklärungen werden Begriffe erläutert, mit denen Erfinder und Patentanmelder am häufigsten konfrontiert werden. Tabellen und Formulare im Anhang geben dem Leser einen Überblick über den typischen Lebenslauf einer Anmeldung und helfen ihm, das Zahlen- und Begriffswerk auf den Deckblättern von Patentschriften zu verstehen. Den Umgang mit den entscheidenden Begriffen im nationalen und internationalen Umfeld klärt ein Verzeichnis von Fachbegriffen in deutscher, englischer und französischer Sprache.