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Recombinant Protein Production With Prokaryotic And Eukaryotic Cells A Comparative View On Host Physiology

Author: Otto-Wilhelm Merten
Publisher: Springer Science & Business Media
ISBN: 9401597499
Size: 63.86 MB
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More then 20 years have passed now since the first recombinant protein producing microorganisms have been developed. In the meanwhile, numerous proteins have been produced in bacteria, yeasts and filamentous fungi, as weIl as higher eukaryotic cells, and even entire plants and animals. Many recombinant proteins are on the market today, and some of them reached substantial market volumes. On the first sight one would expect the technology - including the physiology of the host strains - to be optimised in detail after a 20 year's period of development. However, several constraints have limited the incentive for optimisation, especially in the pharmaceutical industry like the urge to proceed quickly or the requirement to define the production parameters for registration early in the development phase. The additional expenses for registration of a new production strain often prohibits a change to an optimised strain. A continuous optimisation of the entire production process is not feasible for the same reasons.

Pharmaceutical Biotechnology

Author: Gary Walsh
Publisher: John Wiley & Sons
ISBN: 111868575X
Size: 65.32 MB
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Pharmaceutical Biotechnology offers students taking Pharmacyand related Medical and Pharmaceutical courses a comprehensiveintroduction to the fast-moving area of biopharmaceuticals. With aparticular focus on the subject taken from a pharmaceuticalperspective, initial chapters offer a broad introduction to proteinscience and recombinant DNA technology- key areas that underpin thewhole subject. Subsequent chapters focus upon the development,production and analysis of these substances. Finally the book moveson to explore the science, biotechnology and medical applicationsof specific biotech products categories. These include not onlyprotein-based substances but also nucleic acid and cell-basedproducts. introduces essential principles underlining modernbiotechnology- recombinant DNA technology and protein science an invaluable introduction to this fast-moving subject aimedspecifically at pharmacy and medical students includes specific ‘product category chapters’focusing on the pharmaceutical, medical and therapeutic propertiesof numerous biopharmaceutical products. entire chapter devoted to the principles of genetic engineeringand how these drugs are developed. includes numerous relevant case studies to enhance studentunderstanding no prior knowledge of protein structure is assumed

Physiological Stress Responses In Bioprocesses

Author: Sven-Olof Enfors
Publisher: Springer Science & Business Media
ISBN: 9783540203117
Size: 46.61 MB
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This review series covers trends in modern biotechnology. All aspects of this interdisciplinary technology, where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science, are treated. Electronic version available at http://link.springer.de/series/abe/

Biotechnology Of Lactic Acid Bacteria

Author: Fernanda Mozzi
Publisher: John Wiley & Sons
ISBN: 0813820952
Size: 56.31 MB
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This title represents a broad review of current research on LAB and their novel applications with contributions from a number of well-known leading scientists. The book encompasses a wide range of topics including both traditional and novel developing fields, and provides unparalleled, comprehensive information on new advances of genomics, proteomics, metabolism and biodiversity of LAB. Chapters contain state-of-the-art discussions of specific LAB applications such as their use as probiotics, live vaccines and starter cultures in old and new fermented products. The safety of these microorganisms and their interactions with diverse ecosystems natural biota are also covered as well as the new applications of well-known (bacteriocins) and novel (vitamins, low-calorie sugars, etc.) metabolites produced by LAB. This book is an essential reference for established researchers and scientists, doctoral and post-doctoral students, university professors and instructors, and food technologists working on food microbiology, physiology and biotechnology of lactic acid bacteria.

Advancing Science And Elimination Of The Use Of Laboratory Animals For The Development And Control Of Vaccines And Hormones

Author: Fred Brown
Publisher: S Karger Ag
ISBN: 9783805575096
Size: 54.95 MB
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Animal experimentation plays a major role in the development and control of biological products and large numbers of animals are used for routine batch control. During the past few years considerable attention has been paid to the concept of replacing, reducing and refining (the three Rs) the use of animals for this purpose. This volume contains the proceedings of an international meeting held in Utrecht in November 2001 in which the problems associated with applying the three Rs were discussed. Particular emphasis was given to the validation and regulatory acceptance of in vitro methods and new concepts of quality control. Those issues are important for the scientific community at large as well as manufacturers, regulatory authorities and everyone concerned with animal welfare.