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Techniques In Immunocytochemistry

Author: Gillian R. Bullock
Publisher: Academic Pr
Size: 22.32 MB
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An extremely successful series of practical books for cell biologists and pathologists using immunocytochemical techniques. Volumes contain clear descriptions of techniques, plus hints on how to overcome problems and pitfalls. The series is aimed at graduates entering research, senior technicians, and pathologists.

Immunology Methods Manual

Author: Ivan Lefkovíts
Publisher: Academic Press
Size: 77.48 MB
Format: PDF, ePub, Docs
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The Immunology Methods Manual is a fully comprehensive sourcebook of methods and techniques, published in 4 volumes. Unique in its project-oriented rather than protocol-oriented approach, the manual contains both advanced methods and descriptions of basic protocols. These have been meticulously compiled, and carefully presented to guide day-to-day laboratory work, as well as the development of long-term strategies. This 4-volume manual will be essential not only for those who study the immune systems of man or mouse, but also for those applying methods to other species. It will answer the needs of Immunologists, Molecular, Cell and Developmental Biologists, students and advance researchers, and workers in clinical and diagnostic laboratories for a comprehensive and practical guide. Vital contact information will also encourage useful dialogue and interactions between authors and method-users. Led by Ivan Lefkovits, 5 internationally recognised Advisory Editors, over 35 expert Section Editors and over 350,authoritative and experienced authors have contributed to compile this practical guide to methods that work!

Handbook Of Practical Immunohistochemistry

Author: Fan Lin
Publisher: Springer
ISBN: 1493915789
Size: 11.60 MB
Format: PDF, ePub
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In a conceptually current, quick-reference, Question & Answer format, the second edition of Handbook of Practical Immunohistochemistry: Frequently Asked Questions continues to provide a comprehensive and yet concise state-of-the-art overview of the major issues specific to the field of immunohistochemistry. With links to the authors Immunohistochemical Laboratory website, this volume creates a current and up-to-date information system on immunohistochemistry. This includes access to tissue microarrays (TMA) of over 10,000 tumors and normal tissue to validate common diagnostic panels and provide the best reproducible data for diagnostic purposes. Fully revised and updated from the first edition, the new features of the second edition include over 200 additional questions or revised questions with an IHC panel to answer each question; over 250 new color photos and illustrations; over 20 new useful biomarkers; hundreds of new references; several new chapters to cover phosphoproteins, rabbit monoclonal antibodies, multiplex IHC stains, overview of predictive biomarkers, and integration of IHC into molecular pathology; many new coauthors who are international experts in a related field; many updated IHC panels using Geisinger IHC data collected from over 10,000 tumors and normal tissues; and updated appendices containing detailed antibody information for both manual and automated staining procedures. Comprehensive yet practical and concise, the Handbook of Practical Immunohistochemistry: Frequently Asked Questions, Second Edition will be of great value for surgical pathologists, pathology residents and fellows, cytopathologists, and cytotechnologists.

Neuroscience Of Alcohol

Author: Victor R. Preedy
Publisher: Academic Press
ISBN: 0128131268
Size: 42.43 MB
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Neuroscience of Alcohol: Mechanisms and Treatment presents the fundamental information necessary for a thorough understanding of the neurobiological underpinnings of alcohol addiction and its effects on the brain. Offering thorough coverage of all aspects of alcohol research, treatment and prevention, and containing contributions from internationally recognized experts, the book provides students, early-career researchers, and investigators at all levels with a fundamental introduction to all aspects of alcohol misuse. Alcohol is one of the world’s most common addictive substances, with about two billion individuals worldwide consuming it in one form or another and three million annual deaths that are associated with alcohol misuse. Alcohol alters a variety of neurological processes, from molecular biology, to cognition. Moreover, addiction to alcohol can lead to numerous other health concerns and damage virtually every organ system in the body, making diagnosis and treatment of individuals addicted to alcohol of critical importance. Integrates cutting-edge research on the pharmacological, cellular and molecular aspects of alcohol use, along with its effects on neurobiological function Discusses alcohol use as a component of dual-use and poly addictions Outlines numerous screening and treatment strategies for alcohol misuse Covers both the physical and psychological effects of alcohol use and withdrawals to provide a fully-formed view of alcohol dependency and its effects

Molecular Organization Of Membranes Where Biology Meets Biophysics

Author: Marek Cebecauer
Publisher: Frontiers Media SA
ISBN: 2889454096
Size: 16.41 MB
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Biological membranes protect cells and organelles from the surrounding environment, but serve also as organising platforms for physiological processes such as cell signalling. The hydrophobic core of membranes is composed of lipids and proteins influencing each other. Local membrane composition and properties define its molecular organisation and, in this way, regulate the function of all associated molecules. Therefore, studying interactions of components, biophysical properties and overall membrane dynamics provides essential information on its function in the context of cell activities. Such knowledge can contribute to biomedical fields such as pharmacology, immunology, neurobiology and many others. The goal of the Research Topic entitled ‘Molecular organisation of membranes: where biology meets biophysics’ was to provide a comprehensive platform for publishing articles, reviews and opinions focused on membrane organisation and the forces behind its heterogeneous and dynamic structure. We collected 11 works which cover topics as diverse as general membrane organisation models, membrane trafficking and signalling regulation, biogenesis of caveolae, protein-lipid interactions and the importance of membrane-associated tetraspanins networks. The prevalent theme was the existence of membrane nanodomains. To this point, new emerging technologies are presented which own the power to bring a novel insight on how membrane nanodomains are formed and maintained and what is their function. We believe that the collection of works in this Research Topic brings forward some important questions which will stimulate further research in this difficult but exciting field.